Integrins

α1 - View Products

Integrin Alpha-1 is a 1179 aa, type I transmembrane glycoprotein also known as CD49a, VLA-1 α chain, or integrin α1. Integrin Alpha-1 is an adhesion molecule and is involved in the regulation of leukocyte migration, T cell proliferation, and cytokine production.

Function: Leukocyte adhesion and homing, costimulation Distribution: Endothelial cells, fibroblasts, activated T cells Ligands: Collagens, Laminin

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

Heterodimers

α1β1

This heterodimer of integrin α1 and β1 is a collagen IV and alminin-1 receptor that is expressed on activated T cells, smooth muscle cells, endothelial cells, neuronal cells, fibroblasts, and mesenchymal cells. It plays a role in fibroblast proliferation, collagen synthesis, matrix metalloproteinase expression, and renal injury response.

α2 - View Products

Integrin Alpha-2 is a 170 kDa transmembrane protein, also known as CD49b, VLA-2 α chain, Integrin α2, or GPIa. It has been reported to interact with F-actin and matrix metalloproteinase 1. Integrin Alpha-2 is a platelet alloantigen and has been associated with neonatal alloimmune thrombocytopenia. Deficiencies in this protein have been associated with hemorrhagic disorders.

Function: Adhesion

Distribution: B cells, monocytes, platelets, megakaryocytes, neuronal cells, epithelial cells, osteoclasts

Ligands: Collagens, Laminin

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

Heterodimers

α2β1

This heterodimer of integrin α2 and β1, a collagen and alminin receptor, is present on many cell types including monocytes, platelets, activated T cells, megakaryocytes, neuronal cells, epithelial cells, and osteoclasts. It has high affinity for collagen and laminin.

α3 - View Products

Integrin Alpha-3 is a 150 kDa α integrin chain known as CD49c or VLA-3 α chain. It is a type I transmembrane glycoprotein which is proteolytically cleaved into two disulfide linked fragments of 125 kDa and 30 kDa.

Function: Adhesion

Distribution: Endothelial cells, Epithelial cells, dermal fibroblasts

Ligands: Kalinin, Collagen, Laminin-1, Laminin-5, Entactin, Fibronectin

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

Heterodimers

α3β1

This heterodimer of integrin α3 and β1 (CD49c/CD29, VLA-3) is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells and dermal fibroblasts. Weak expression has been reported on leukocytes. VLA-3 plays a role in cell-cell and cell-matrix adhesion through binding kalinin, collagen, laminin-1, laminin-5, entactin, and fibronectin.

α4 - View Products

Integrin Alpha-4 is a 150 kDa α integrin chain known as CD49d or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). It is expressed broadly on many cells, but not on normal red blood cells, platelets or neutrophils. It also participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. It is a marker used to isolate pure populations of human Treg cells due to its absence on FOXP3+ cells. The 9F10 antibody can co-stimulate T cells for activation.

Function: Lymphocyte migration, T cell activation, stem cell differentiation

Distribution: T, B, and NK cells, dendritic cells, thymocytes, monocytes, eosinophils, mast cells Ligands: Fibronectin, VCAM-1, MAdCAM-1

β7 - View Products

Integrin β7 is a 130 kDa glycoprotein, also known as integrin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4β7 or αEβ7 heterodimer. The FIB27 antibody has been reported to react with mouse and human β7 integrin and to block β7 integrin-mediated cell adhesion in in vitro and in vivo studies.

Function: Lymphocyte adhesion, hematopoietic progenitor cell migration

Distribution: Majority of lymphocytes, thymocyte subset, and some bone marrow progenitors, intestinal intraepithelial lymphocytes, dendritic epidermal T cells, subset of CD8 T cells in lymph nodes

Ligands: VCAM-1 (CD106), MAdCAM-1, Fibronectin, E-cadherin

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells Ligands: VCAM-1, MAdCAM-1, extracellular matrix

α4β1

This heterodimer consists of α4 and β1. It binds to VCAM-1 (CD106) and fibronectin. α4β1 is predominantly expressed on hematopoietic stem cells. While it is primarily known for aiding in leukocyte adhesion to endothelium and extracellular matrix, it is noted as being involved in co-stimulating T cells.

α4β7 - View Products

Integrin α4β7 is composed of an α4 and a β7 heterodimer, also known as CD49d/β7, or LPAM-1. It belongs to Ig superfamily found on majority of peripheral lymphocytes, subsets of thymocytes, and bone marrow cells (including mast cell progenitors). Integrin α4β7 binds its ligands, VCAM-1 (CD106), MAdCAM-1, and fibronectin, and plays an important role in lymphocyte adhesion and helps direct the migration of blood lymphocytes to the intestine and associated lymphoid tissues. It has been reported that clone  DATK32 is able to block α4β7-mediated lymphocyte adhesion to VCAM-1, MAdCAM-1 and fibronectin in vitro and in vivo.

α5 - View Products

Integrin Alpha-5 is a type I integral membrane glycoprotein, known as CD49e and VLA-5 α chain. It forms noncovalent heterodimer with integrin β1 (CD29). CD49e contains two disulfide-linked subunits of 135 kDa and 24 kDa.

Function: Adhesion, regulation of cell survival and apoptosis

Distribution: Thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, and some myeloid leukemia cells

Ligands: Fibronectin, Neutral Adhesion Molecule L1, Vitronectin

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

β3 - View Products

Integrin Beta-3, also known as CD61 or glycoprotein IIIa (gpIIIa), is a 90 kDa type I integral transmembrane glycoprotein. It is a member of integrin family that associates with platelet gpIIb (CD41), forming αIIbβ3 complex. It also associates with integrin αV (CD51), forming αVβ3 integrin. 

Function: Adhesion, platelet activation and aggregation

Distribution: Platelets, megakaryocytes, platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells

Ligands: Fibronectin, Vitronectin, von Willebrand Factor

β5 - View Products

Integrin β5 is a 95 kDa glycoprotein heterodimer with the αV and α5 subunits and is found on many types of tissue cells. The αV/β5 integrin complex binds to vitronectin.

Function: Cell adhesion

Distribution: Epithelial cells, endothelial cells, keratinocytes, osteoblastic cells

Ligands: Vitronectin

β6 

Integrin Beta-6 has a molecular weight of 95 kDa and is known to associate with α5 and αV integrins. Its expression is typically restricted to epithelia, particularly after injury or inflammation. Integrin Beta-6 is known to participate in the activation of latent TGF-β.

Function: Cell Adhesion

Distribution: Epithelial Cells

Ligands: Fibronectin, Cyotactin

α6 - View Products

Integrin Alpha-6 is a 120 kDa integrin family member, also known as VLA-6 α chain and CD49f. Integrin Alpha-6 associates with either integrin β1 (CD29) or integrin β4 (CD104) to form receptors (VLA-6 or α6β4 complex) for laminin and kalinin. CD49f is involved in adhesion and can act as a co-stimulatory molecule for T cell activation and proliferation. The GoH3 antibody has been reported to block laminin binding in vitro and to block integrin α6 function in vivo.

Function: Adhesion, T cell co-stimulation and activation

Distribution: Platelets, Monocytes, T Cells, Placental Trophoblasts, Epithelial, and Endothelial Cells

Ligands: Laminin, Kalinin

β4 - View Products

Integrin Beta-4 is a 205 kDa type I transmembrane glycoprotein, known as CD104 or β4 integrin, that associates with integrin α6 (CD49f) to form the α6β4 (CD49f/CD104) heterodimer. 

Function: Adhesion

Distribution: Epithelial cells, endothelial cells, some tumor cells, Schwann cells, pre-T cell subset

Ligands: Laminins, keratin filaments

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

α6β1

Integrin α6β1, also known as VLA-6, CD49f/CD29, is composed of a α6 and a β1 heterodimer and binds to laminin, thrombospondin, and Cyr61. Originally found on platelets, α6β1 has also been found on monocytes, thymocytes, epithelial and endothelial cells. It functions as a mediator for leukocyte migration. α6β1 also co-stimulates and activates T cells.

α6β4

Integrin α6β4 is composed of an α6 and a β4 heterodimer. This protein is found primarily in epithelial cells. The α6β4 integrin is vital in strengthening and stabilizing the skin. It helps form hemidesmosomes, which are microscopic structures that anchor the epidermis to underlying layers. Essentially, α6β4 integrin helps to hold the layers of skin together.

α7 

Integrin Alpha-7 is a 1181 aa sequence that associates with integrin β1 (CD29), binding to laminin. Primarily found in muscle cells, Integrin Alpha-7 aids in the movement and development of myoblasts (muscle progenitor cells). It has been shown to be vital in the maintenance of myofiber architecture and integrity.

Function: Adhesion, cell shape

Distribution: Muscle Cells, skeletal myoblasts, adult myofibers

Ligands: Laminin

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

α7β1

Integrin α7β1 is composed of an α7 and a β1 heterodimer. It serves as the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, helping to localize them at laminin-rich areas for secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture, anchorage, viability, and functional integrity.

α8

Integrin Alpha-8 is a 1063 aa sequence that associates with integrin β1 (CD29) that recognizes a wide array of ligands with the Arginine-Glycine-Aspartic Acid (RGD) sequence. It has been implicated in the formation of several organs.

Function: Adhesion, differentiation, neurogenesis

Distribution: Mesenchymal cells, alveolar myofibroblasts, kidney mesangial cells, hepatic stellar cells, vascular and visceral smooth muscle

Ligands: LAP-TGF-β, Nephronectin, POEM, Tenascin-C

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

α8β1

Integrin α8β1 is composed of an α8 and a β1 heterodimer. Its function in kidney genesis, and other organs, is to recruit mesenchymal cells into epithelial structures. As a neuronal receptor for Tenascin-C, it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

α9

Integrin Alpha-9 is a 1035 aa sequence that associates with integrin β1 (CD29) widely expressed on smooth muscle cells, skeletal muscle, hepatocytes, and keratinocytes.

Function: Adhesion, migration

Distribution: Neutrophils, monocytes, endothelial cells, hematopoietic cells, muscle cells, hepatocytes, keratinocytes

Ligands: VCAM-1, Tenascin C, Osteopontin, Cytotactin

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

α9β1 - View Products

Integrin α9β1 is a transmembrane protein belonging to the integrin family. It is widely expressed in airway epithelium, different types of muscle cells, and hepatocytes. In the hematopoietic system, integrin α9β1 is highly expressed on human neutrophils and at low levels on monocytes. Multiple ligands have been identified for this integrin, including the inducible endothelial counter-receptor, VCAM-1, Tenascin C and Osteopontin, some members of ADAMs family, coagulation factor XIII, and von Willebrand Factor. It has been reported that binding of the α9 cytoplasmic domain to spermidine/spermine N(1)-acetyltransferase (SSAT) mediates α9β1 enhancement of cell migration, adhesion to extracellular matrix protein, and G-CSF signaling. Integrin α9β1 was also found on hematopoietic stem and progenitor cells, mediating stem cells adhesion, proliferation, and differentiation.

α10

Integrin Alpha-10 is a 1167 aa sequence that associates with integrin β1 (CD29) and binds to a novel collagen type II receptor. This integrin is mainly expressed by chondrocytes and cartilage tissue.

Function: Adhesion

Distribution: Muscle and heart tissue, articular cartilage

Ligands: Collagen

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

α10β1

Integrin α10β1 is composed of an α10 and a β1 heterodimer. Its expression is highest in muscle and heart tissue, but it has recently been found in cartilage tissue as well. Disruption of α10β1 led to dysfunctional growth of plate chondrocytes.

α11

Integrin Alpha-11 is a 1167 aa sequence, making it the longest integrin α chain to date. α11 associates with integrin β1 (CD29) to bind collagen.

Function: Adhesion

Distribution: Mesenchymal cells, uterus, heart tissue

Ligands: Collagen

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

α11β1

Integrin α11β1 is composed of an α11 and a β1 heterodimer. α11β1 binds collagen as its main ligand, preferentially Type I collagens. It has also been found to be expressed on mesenchymal stem cells and is considered a marker for non-muscle mesenchymal tissue.

αD

Integrin Alpha-D is a 1161 aa sequence also known as CD11d. Currently, it has only been found to associate with integrin β2 (CD18). Integrin Alpha-D is primarily expressed by myeloid-derived leukocytes and can be upregulated on monocytes and neutrophils upon stimulation.

Function: Adhesion, migration

Distribution: Macrophages, Monocytes, Neutrophils

Ligands: ICAM3, VCAM1, Fibronectin, Vitronectin, Fibrinogen, Cyr61

β2 - View Products

Integrin Beta-2 is a 90-95 kDa type I transmembrane protein also known as CD18, LFA-1 β subunit, and β2 integrin. Integrin Beta-2 non-covalently associates with CD11a (αL), CD11b (αM) or CD11c (αX). Integrin Beta-2 is expressed on all leukocytes. Integrin Beta-2 and its associated α chains function in adhesion and signaling in hematopoietic cells.

Function: Adhesion and signaling in hematopoietic system

Distribution: Leukocytes

Ligands: ICAMs

αDβ2

Integrin αDβ2 is composed of an αD and a β2 heterodimer. As αDβ2 shares high homology with αMβ2, it also shares several of its ligands and promiscuous binding nature. αDβ2 levels have been found to increase as monocytes differentiate into macrophages. Additionally, it is strongly upregulated in macrophages found in atherosclerotic plaques.

αE - View Products

Integrin Alpha-E is a type I transmembrane glycoprotein also known as integrin αIEL chain, CD103, and human mucosal lymphocyte antigen 1. T regulatory cells express high levels of Integrin Alpha-E. Hairy cell leukemia cells have also been shown to express CD103. Its expression on lymphocytes can be induced upon activation and TGF-β stimulation.

Function: Retention and activation of αE+ lymphocytes in the intestinal epithelium, regulation of tissue-specific T cell homing

Distribution: Intestinal Epithelial Lymphocytes (IEL), subpopulation of Lamina Propia T cells, epithelial dendritic cells, small subset of peripheral lymphocytes, T Regulatory cells

Ligands: E-Cadherin

β7 - View Products

Integrin β7 is a 130 kDa glycoprotein, also known as integrin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4β7 or αEβ7 heterodimer. The FIB27 antibody has been reported to react with mouse and human β7 integrin and to block β7 integrin-mediated cell adhesion in in vitro and in vivo studies.

Function: Lymphocyte adhesion, hematopoietic progenitor cell migration

Distribution: Majority of lymphocytes, thymocyte subset, and some bone marrow progenitors, intestinal intraepithelial lymphocytes, dendritic epidermal T cells, subset of CD8 T cells in lymph nodes

Ligands: VCAM-1 (CD106), MAdCAM-1, Fibronectin, E-cadherin

αEβ7

Integrin αEβ7 consists of a heterodimer of αE and β7. Its only known ligand is E-Cadherin. It is thought to be induced by TGF-β and correspondingly, is found highly elevated in Tregs. αEβ7’s expression is typically restricted to mucosal tissue, particularly aiding in a gut-homing response. Initially used to identify intestinal intraepithelial lymphocytes, αEβ7 has been found in a few other cell types (dendritic cells, Tregs).

αIIb - View Products

Integrin αIIb, also known as CD41, is a 125/25 kDa α subunit of the αIIbβ3 (CD41/CD61) complex. Integrin αIIb is a heterodimer composed of a heavy chain (gpIIbα) and light chain (gpIIbβ) linked by a single disulfide bond. αIIb has been reported to be involved with platelet aggregation and attachment to the extracellular matrix.

Function: Platelet aggregation and attachment to the extracellular matrix

Distribution: Platelets, megakaryocytes

Ligands: Fibrinogen, Fibronectin, von Willebrand Factor, Thrombin

β3 - View Products

Integrin Beta-3, also known as CD61 or glycoprotein IIIa (gpIIIa), is a 90 kDa type I integral transmembrane glycoprotein. It is a member of integrin family that associates with platelet gpIIb (CD41) and integrin αV (CD51). It plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. 

Function: Adhesion, platelet activation and aggregation

Distribution: Platelets, megakaryocytes, osteoclasts, fibroblasts, macrophages and some tumor cells

Ligands: Fibronectin, Vitronectin, von Willebrand Factor

αIIbβ3 - View Products

Integrin αIIbβ3 consists of a heterodimer of αIIb and β3. It is highly expressed by platelets and megakaryocytes. Following activation, integrin αIIbβ3 brings about platelet to platelet interaction by binding soluble fibrinogen. This leads to rapid platelet aggregation, which physically plugs up any ruptured areas in the endothelial cell surface.

αL - View Products

Integrin Alpha-L is a 170-180 kDa type I transmembrane glycoprotein also known as LFA-1α chain and integrin αL subunit. CD11a non-covalently associates with integrin β2 (CD18) to form LFA-1. It is expressed on all leukocytes, including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils, but absent on non-hematopoietic tissues and platelets. CD11a plays a central role in leukocyte cell-cell interactions and is important in lymphocyte costimulation. 

Function: Adhesion, costimulation

Distribution: Leukocytes

Ligands: ICAM-1, ICAM-2, ICAM-3, ICAM-4

β2 - View Products

Integrin Beta-2 is a 90-95 kDa type I transmembrane protein also known as CD18, LFA-1 β subunit, and β2 integrin. Integrin Beta-2 non-covalently associates with CD11a (αL), CD11b (αM) or CD11c (αX). Integrin Beta-2 is expressed on all leukocytes. Integrin Beta-2 and its associated α chains function in adhesion and signaling in hematopoietic cells.

Function: Adhesion and signaling in hematopoietic system

Distribution: Leukocytes

Ligands: ICAMs

αLβ2 - View Products

Integrin αLβ2 consists of a heterodimer of αL and β2 subunits. It is a receptor for ICAM1-4, and is involved with a variety of immunological processes, including costimulatory signaling, leukocyte-endothelial cell interaction, T cell-mediated cytotoxic killing, and antibody-dependent killing by granulocytes and monocytes.

αM - View Products

Integrin Alpha-M is a 165-170 kDa type I transmembrane glycoprotein also known as CD11b, Mac-1, CR3, and C3biR. Integrin Alpha-M non-covalently associates with integrin β2 (CD18).

Function: Adhesion, phagocytosis, chemotaxis, neutrophil activation

Distribution: Granulocytes, monocytes, macrophages, dendritic cells, NK cells, subset of T cells, subset of B cells

Ligands: ICAM-1, ICAM-2, ICAM-4, CD14, CD23, Heparin, iC3b, Fibrinogen, Factor X

β2 - View Products

Integrin Beta-2 is a 90-95 kDa type I transmembrane protein also known as CD18, LFA-1 β subunit, and β2 integrin. Integrin Beta-2 non-covalently associates with CD11a (αL), CD11b (αM) or CD11c (αX). Integrin Beta-2 is expressed on all leukocytes. Integrin Beta-2 and its associated α chains function in adhesion and signaling in hematopoietic cells.

Function: Adhesion and signaling in hematopoietic system

Distribution: Leukocytes

Ligands: ICAMs

αMβ2 

αMβ2 is critical for the transendothelial migration of monocytes and neutrophils. It is also involved in granulocyte adhesion, phagocytosis, and neutrophil activation. αMβ2 interacts with ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4, CD14, CD23, heparin, iC3b, fibrinogen, and Factor X.

αV - View Products

Integrin Alpha-V is a type I integral membrane glycoprotein, known as vitronectin receptor α chain, or CD51. It forms a heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. It contains two disulfide-linked subunits of 125 kDa and 24 kDa. Many extracellular matrix proteins with RGD-motifs are Integrin Alpha-V ligands. As an adhesion molecule, it plays important roles in angiogenesis, leukocyte homing and rolling, and bone absorption.

Function: Adhesion, angiogenesis

Distribution: Endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells

Ligands: Vitronectin, von Willebrand Factor, Fibrinogen, Thrombospondin, Osteopontin, Denatured Collagen, Fibronectin, Laminin

β1 - View Products

Integrin Beta-1 is a 130 kDa single chain type I glycoprotein, known as CD29, VLA-β chain, or gpIIa. It is non-covalently associated with integrin α1-α6 chains to form VLA-1 to VLA-6 molecules, respectively. Heterodimers that include Integrin Beta-1 bind to several cell and extracellular matrix molecules. It acts as a fibronectin receptor and is involved in a variety of cell-cell and cell-matrix interactions.

Function: Cell-cell and cell-matrix interactions

Distribution: Lymphocytes, monocytes, granulocytes (low), platelets, mast cells, fibroblasts, endothelial cells

Ligands: VCAM-1, MAdCAM-1, extracellular matrix

β3 - View Products

Integrin Beta-3, also known as CD61 or glycoprotein IIIa (gpIIIa), is a 90 kDa type I integral transmembrane glycoprotein. It is a member of integrin family that associates with platelet gpIIb (CD41), forming αIIbβ3 complex. It also associates with integrin αV (CD51), forming αVβ3 integrin. 

Function: Adhesion, platelet activation and aggregation

Distribution: Platelets, megakaryocytes, platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells

Ligands: Fibronectin, Vitronectin, von Willebrand Factor

β5 - View Products

Integrin β5 is a 95 kDa glycoprotein heterodimer with the αV and α5 subunits and is found on many types of tissue cells. The αV/β5 integrin complex binds to vitronectin.

Function: Cell adhesion

Distribution: Epithelial cells, endothelial cells, keratinocytes, osteoblastic cells

Ligands: Vitronectin

β6 

Integrin Beta-6 has a molecular weight of 95 kDa and is known to associate with α5 and αV integrins. Its expression is typically restricted to epithelia, particularly after injury or inflammation. Integrin Beta-6 is known to participate in the activation of latent TGF-β.

Function: Cell Adhesion

Distribution: Epithelial Cells

Ligands: Fibronectin, Cyotactin

β8

Integrin Beta-8 is a 90 kDa glycoprotein known to associate with integrin αV. Its ligands include vitronectin, fibrin, and latency associated peptide (LAP).

Function: Adhesion, Morphogenesis

Distribution: Astrocytes, Schwann Cells, Renal Glomerular Mesangial Cells, Pulmonary Epithelial Cells, Placenta, Kidney, Brain, Ovary, Uterus

Ligands: Fibronectin, Vitronectin, LAP

αVβ1

Integrin αVβ1 consists of a heterodimer of αV and β1 subunits. As each of these subunits is widely expressed, a wide variety of cells can express this heterodimer. αVβ1 is expressed early in differentiation for oligodendrocytes, astrocytes and pancreatic β cells, but down-regulated following their differentiation. αvβ1 has also been implicated as a receptor for certain types of virus, like human metaneumovirus.

αVβ3

Integrin αVβ3 consists of a heterodimer of αV and β3 subunits and is found on many cell types, including differentiated macrophages, melanoma cells, endothelial cells, osteoclasts, and at very low levels by platelets. Its main ligands include fibronectin, vitronectin, and thrombospondin. αVβ3 allows interaction with the extracellular matrix and inflamed tissue. It is highly expressed on activated and growing cells under pathological conditions, possibly signifying its role in several diseases like cancer and rheumatoid arthritis.

αVβ5

Integrin αVβ5 consists of a heterodimer of αV and β5 subunits. It functions as a receptor for vitronectin and can be found on hepatoma cells, carcinoma cells, fibroblasts, endothelial, and epithelial cells. It has been associated with tumor progression, as it is an inducer of angiogenesis.

αVβ6 - View Products

Integrin αVβ6 consists of a heterodimer of αV and β6 subunits. It is expressed almost exclusively by certain types of epithelial cells, particularly after injury or inflammation. It binds to tenascin C and fibronectin. It has also been found to bind latency-associated peptide (LAP) and can activate latent TGFβ complexes. Several viruses can use αVβ6 as a receptor for cell entry.

αVβ8  - View Products

Integrin αVβ8 consists of a heterodimer of αV and β8 subunits. β8 integrin is only known to associate with αV. It is expressed in several cell types, including pulmonary epithelial cells, astrocytes, Schwann Cells, yolk sac, placenta, and renal glomelular mesangial cells. It binds fibrin and vitronectin. It has also been found to bind to the latency-associated peptide (LAP) of the latent TGFβ complex, activating it by cleaving LAP. It has also been shown to be necessary for proper vascular morphogenesis in the yolk sac and embryonic brain.

αX - View Products

Integrin Alpha-X is a 145-150 kDa type I transmembrane glycoprotein also known as CD11c and CR4. Integrin Alpha-X non-covalently associates with integrin β2 (CD18). Integrin Alpha-X has been reported to play a role in adhesion and cytotoxic T lymphocyte killing through its interactions with fibrinogen, CD54, and iC3b.

Function: Adhesion, CTL killing

Distribution: Myeloid cells, dendritic cells, NK cells, B and T cell subsets

Ligands: CD54, Fibrinogen, iC3b, ICAM-1, ICAM-4

β2 - View Products

Integrin Beta-2 is a 90-95 kDa type I transmembrane protein also known as CD18, LFA-1 β subunit, and β2 integrin. Integrin Beta-2 non-covalently associates with CD11a (αL), CD11b (αM) or CD11c (αX). Integrin Beta-2 is expressed on all leukocytes. Integrin Beta-2 and its associated α chains function in adhesion and signaling in hematopoietic cells.

Function: Adhesion and signaling in hematopoietic system

Distribution: Leukocytes

Ligands: ICAMs

αXβ2 

αXβ2 integrin consists of an αX and a β2 heterodimer, expressed by macrophages and dendritic cells. It can also be expressed in lower amounts by NK, B cells, and some cytotoxic T cells. αXβ2 has been known to bind iC3b, ICAMs, and fibrinogen. While it shares many ligands with αMβ2, αXβ2 typically requires cell activation to be functional. αXβ2 aids in several immunological functions, including proliferation, migration, degranulation, and the uptake and phagocytosis of particles opsonized via complement.