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APC anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
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Product Citations
publications
BM8_APC_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
  • BM8_APC_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
Compare all formats See APC spectral data
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123115 25 µg 40€
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123116 100 µg 115€
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Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The F4/80 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  2. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
  3. Huang W, et al. 2015. J Allergy Clin Immunol. . PubMed
  4. Barrett N, et al. 2016. Cell Rep. 16: 1039-1054. PubMed
  5. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  6. Zhao Z, et al. 2021. Nat Commun. 12:4355. PubMed
  7. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  8. Nguyen T, et al. 2021. STAR Protoc. 2:101004. PubMed
  9. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  10. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  11. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  12. Yang D, et al. 2022. Cell. 185:1905. PubMed
  13. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  14. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  15. Nesseler JP, et al. 2020. Cancers (Basel). 12: . PubMed
  16. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  17. Fang C, et al. 2022. J Pathol. 256:310. PubMed
  18. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  19. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  20. Yousefi M, et al. 2022. Cancer Res. 82:1589. PubMed
  21. Chen J, et al. 2022. Adv Sci (Weinh). 9:e2200668. PubMed
  22. Sipilä K, et al. 2022. Dev Cell. 57:1453. PubMed
  23. Jang HJ, et al. 2022. Cancer Res. 82:2593. PubMed
  24. Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed
  25. Xu J, et al. 2022. Invest Ophthalmol Vis Sci. 63:15. PubMed
  26. Schaue D, et al. 2022. Antioxidants (Basel). 11: . PubMed
  27. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  28. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  29. Yoo HJ, et al. 2022. Cell Rep. 41:111598. PubMed
  30. Nagre N, et al. 2022. Respir Res. 23:326. PubMed
  31. Miao Y, et al. 2022. Front Pharmacol. 13:1032741. PubMed
  32. Kuo CS, et al. 2022. Elife. 11: . PubMed
  33. Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed
  34. Wang R, et al. 2023. Nat Biomed Eng. 7:38. PubMed
  35. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  36. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  37. Wang Y, et al. 2023. FASEB J. 37:e22776. PubMed
  38. Fontana MF, et al. 2023. Elife. 12: . PubMed
  39. Kulkarni R, et al. 2023. Life Sci Alliance. 6: . PubMed
  40. Slusarczyk P, et al. 2023. Elife. 12: . PubMed
  41. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  42. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  43. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  44. Li FJ, et al. 2022. Am J Physiol Lung Cell Mol Physiol. 322:L593. PubMed
  45. Kraynak CA, et al. 2022. Int J Pharm. 618:121634. PubMed
  46. Fernández-García V, et al. 2022. Biomed Pharmacother. 148:112769. PubMed
  47. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  48. Quattrocelli M, et al. 2022. J Exp Med. 219:. PubMed
  49. Hailemichael Y, et al. 2022. Cancer Cell. 40:509. PubMed
  50. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  51. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  52. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  53. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  54. Czimmerer Z, et al. 2022. Immunity. 55:2006. PubMed
  55. Amodio V, et al. 2023. Cancer Cell. 41:196. PubMed
  56. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  57. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  58. Liu PS, et al. 2023. Nat Immunol. 24:452. PubMed
  59. Mizutani T, et al. 2023. iScience. 26:106081. PubMed
  60. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  61. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  62. Wang Y, et al. 2023. EBioMedicine. 90:104480. PubMed
  63. Tan J, et al. 2023. Acta Pharm Sin B. 13:632. PubMed
  64. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  65. Zhu S, et al. 2023. J Nanobiotechnology. 21:81. PubMed
  66. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  67. He XY, et al. 2023. Nat Commun. 14:2253. PubMed
  68. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  69. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  70. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  71. Shen Z, et al. 2023. iScience. 26:106572. PubMed
  72. Ji Y, et al. 2023. Nat Cell Biol. 25:726. PubMed
  73. He Y, et al. 2023. Biomolecules. 13:. PubMed
  74. Wang C, et al. 2023. Int J Oral Sci. 15:19. PubMed
  75. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  76. Song S, et al. 2023. Bioact Mater. 28:358. PubMed
  77. Du, J., Fan, Y., et al. 2025. Oncoimmunology. 14(1),2590245. PubMed
  78. Prantner D, et al. 2009. Infect Immun. 77:5334. PubMed
  79. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  80. Kim SE, et al. 2019. Nutrients. 11. PubMed
  81. Chang T, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006485. PubMed
  82. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  83. Du J, et al. 2020. Developmental Cell. 55(6):737-753.e7. PubMed
  84. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  85. Bousset L, et al. 2020. PLoS Biol. 18:e3000948. PubMed
  86. Yu J, et al. 2020. Sci Rep. 10:21360. PubMed
  87. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  88. Emal D, et al. 2016. J Am Soc Nephrol. 10.1681/ASN.2016030255. PubMed
  89. Dale M, et al. 2016. J Immunol. 196: 4536 - 4543. PubMed
  90. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  91. Jaiswal M, et al. 2015. Sci Rep. 5: 15221. PubMed
  92. Bieren J, et al. 2015. J Immunol. 194:1154. PubMed
  93. Yan X, et al. 2022. Commun Biol. 5:320. PubMed
  94. Li Y, et al. 2022. Int J Biol Sci. 18:3697. PubMed
  95. He R, et al. 2021. J Immunol. 206:2353. PubMed
  96. Suresh R, et al. 2020. J Immunother Cancer. 8:. PubMed
  97. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  98. Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed
  99. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  100. He F, et al. 2021. J Exp Med. 218:. PubMed
  101. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  102. Yates C, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0644-9. PubMed
  103. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  104. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  105. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  106. Stubelius A, et al. 2012. Immunobiology. 217:751. PubMed
  107. Sjöstrand M, et al. 2013. J Immunol. 191:3753. PubMed
  108. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  109. Tan X, et al. 2016. PLoS One. 11: 0160985. PubMed
  110. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  111. Dong L, et al. 2021. Cancer Cell. . PubMed
  112. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  113. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  114. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  115. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  116. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  117. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  118. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  119. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  120. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  121. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  122. Xu Y, et al. 2020. Mol Ther. 28:202. PubMed
  123. Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
  124. Xing J, et al. 2016. Nat Immunol. 17:1373-1380. PubMed
  125. Zhu J, et al. 2016. Sci Rep. 6:27136. PubMed
  126. Sun P, et al. 2015. J Hepatol. . PubMed
  127. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  128. Gritsina G, et al. 2015. Mol Cancer Ther. 14:1035. PubMed
  129. Han J, et al. 2022. FEBS J. 289:417. PubMed
  130. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  131. Liang F, et al. 2021. Front Immunol. 12:658715. PubMed
  132. Qi F, et al. 2017. Molecular Immunology. 10.1016/j.molimm.2017.05.008. PubMed
  133. Stefan K, et al. 2017. PLoS One. . 10.1371/journal.pone.0188600. PubMed
  134. Sinha M, et al. 2018. Nat Commun. 9:936. PubMed
  135. Grohmann M et al. 2018. Cell. 175(5):1289-1306 . PubMed
  136. Kosack L, et al. 2017. Sci Rep. 7:11289. PubMed
  137. Christopher S Garris et al. 2018. Immunity. 49(6):1148-1161 . PubMed
  138. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  139. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  140. Rybalko V, et al. 2015. PLoS One. 10: 0145550. PubMed
  141. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  142. Tajfirouz D, et al. 2017. Virology. 10.1016/j.virol.2017.02.022. PubMed
  143. Krivanek J, et al. 2020. Nat Commun. 3.802777778. PubMed
  144. Brestoff JR, et al. 2021. Cell Metab. 33:270. PubMed
  145. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  146. Esmaili S, et al. 2021. Cell Systems. 12(5):432-445.e7. PubMed
  147. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  148. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  149. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  150. Peng L, et al. 2020. Transl Lung Cancer Res. 0.892361111. PubMed
  151. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  152. Nguyen CM, et al. 2019. Diabetes. 68:1499. PubMed
  153. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  154. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  155. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  156. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  157. Shang Y, et al. 2016. Nat Immunol. 10.1038/ni.3486. PubMed
  158. Lasky C, et al. 2015. Infect Immun . 83: 2627 - 2635. PubMed
  159. Wang Y, et al. 2022. Front Immunol. 13:767630. PubMed
  160. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  161. Kosaric N, et al. 2020. Mol Ther. 28:2007. PubMed
  162. Ling X, et al. 2021. ACS Nano. 15:765. PubMed
  163. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  164. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  165. Luan HH et al. 2019. Cell. 178(5):1231-1244 . PubMed
  166. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  167. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  168. Galvão I, et al. 2018. Front Immunol. 9:142. PubMed
  169. Alexander RK, et al. 2020. eLife. 9:e54090.. PubMed
  170. Prantner D, et al. 2011. Infect Immun. 79:3922. PubMed
  171. Helmi N, et al. 2015. J Infect Dis. 211:1677. PubMed
  172. Tsoyi K, et al. 2015. J Leukoc Biol. 97:171. PubMed
  173. Ma Y, et al. 2015. Cardiovasc Res. 106:421. PubMed
  174. Ben-Shaanan T, et al. 2016. Nat Med. 10.1038/nm.4133. PubMed
  175. Karki R, et al. 2020. JCI Insight. 5:00. PubMed
  176. Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
  177. Sun L, et al. 2020. J Immunol. 2177:204. PubMed
  178. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  179. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  180. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  181. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  182. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  183. Oatley J, et al. 2009. Development. 136:1191. PubMed
  184. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  185. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  186. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  187. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  188. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  189. Carozza JA, et al. 2020. Nat Cancer. 184:1. PubMed
  190. Agrawal V, et al. 2016. J Leukoc Biol. 100: 261 - 274. PubMed
  191. Amash A, et al. 2016. J Immunol. 196: 3331-3340. PubMed
  192. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  193. Sullivan B, et al. 2015. PLoS Pathog. 11:1004588. PubMed
  194. Zein HS, et al. 2022. Sci Rep. 12:4834. PubMed
  195. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  196. Lv F, et al. 2022. iScience. 25:103639. PubMed
  197. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  198. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  199. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  200. Gao H, et al. 2021. Cells. 10:. PubMed
  201. Chen F et al. 2018. Cell reports. 25(10):2775-2783 . PubMed
  202. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  203. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  204. Glauser D, et al. 2013. J Virol. 87:10828. PubMed
  205. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  206. Hara-Chikuma H 2016. Mol Cell Biol. 36: 1206-1218. PubMed
  207. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  208. DeVito NC, et al. 2021. Cell Reports. 35(5):109071. PubMed
  209. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  210. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  211. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  212. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  213. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  214. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  215. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  216. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  217. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  218. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  219. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  220. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  221. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  222. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  223. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  224. Moon HG et al. 2018. Immunity. 49(2):275-287 . PubMed
  225. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  226. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  227. Matundan H, et al. 2019. J Virol. 93. PubMed
  228. Yu L, et al. 2019. Elife. 8:e46677. PubMed
  229. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  230. Li Y, et al. 2020. Cell Reports. 27(10):2809-2816.e3.. PubMed
  231. Fairfax K, et al. 2013. J Immunol. 191:4202. PubMed
  232. Ericson J, et al. 2014. PLoS One. 9:108553. PubMed
  233. Toda G, et al. 2021. STAR Protoc. 2:100246. PubMed
  234. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  235. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  236. Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
  237. Pfefferlé M, et al. 2021. Front Immunol. 12:680855. PubMed
  238. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  239. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  240. Yang Y, et al. 2022. Elife. 11:. PubMed
  241. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  242. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  243. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  244. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  245. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  246. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  247. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  248. Zheng X, et al. 2018. J Clin Invest. 128:2104. PubMed
  249. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  250. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  251. Dewi IMW, et al. 2021. Cell Reports Medicine. 2(5):100289. PubMed
  252. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  253. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  254. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  255. Kostadinova E, et al. 2016. Sci Rep. 6:30943. PubMed
  256. Tan X, et al. 2015. Sci Rep. 5: 15702. PubMed
  257. Kuwahara G, et al. 2014. PLoS One. 9:106987. PubMed
  258. Patankar Y, et al. 2013. Infect Immun . 81:2043. PubMed
  259. Chung EJ, et al. 2022. Aging (Albany NY). 14:7692. PubMed
  260. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  261. Lang V, et al. 2021. Elife. 10:. PubMed
  262. Jaggi U, et al. 2021. PLoS Pathog. 17:e1009999. PubMed
  263. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  264. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  265. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  266. Cao Q, et al. 2019. Theranostics. 5.576388889. PubMed
  267. Kim K, et al. 2014. Proc Natl Acad Sci U S A. 111:11774. PubMed
  268. Hu J, et al. 2015. J Hepatol. Available online 31 August 2015. PubMed
  269. Terrazas M 2014. Int J Parasit. 44 613 . PubMed
  270. Yang C, et al. 2016. Sci Rep. 6:34643. PubMed
  271. Jiang Q, et al. 2020. JCI Insight. 5:00. PubMed
  272. Kesavardhana S, et al. 2020. J Biol Chem. 295:8325. PubMed
  273. Ye ZH, et al. 2021. Transl Oncol. 14:101162. PubMed
  274. Ito T, et al. 2021. Nat Commun. 12:2232. PubMed
  275. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  276. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  277. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  278. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  279. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  280. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  281. Li D, et al. 2022. Emerg Microbes Infect. 11:2248. PubMed
  282. Rosenbaum SR, et al. 2020. Cell Rep. 30:510. PubMed
  283. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  284. Petkevicius K, et al. 2019. Elife. 8:e47990. PubMed
  285. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  286. Engblom C, et al. 2017. Science. 358:6367. PubMed
  287. Zhao F et al. 2018. Immunity. 48(1):147-160 . PubMed
  288. Lima-Junior D, et al. 2017. J Immunol. 10.4049/jimmunol.1700258. PubMed
  289. Ishikura S, et al. 2021. J Cell Biochem. . PubMed
  290. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  291. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  292. Chen Z, et al. 2016. Nat Commun. 7:11596. PubMed
  293. Deng W, et al. 2015. Clin Immunol. . PubMed
  294. Honda H, et al. 2014. J Leukoc Biol. 96:1087. PubMed
  295. Shaw O, et al. 2014. Rheumatology. 53:1901. PubMed
  296. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  297. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  298. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  299. Chen F, et al. 2022. Cell Rep. 38:110215. PubMed
  300. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  301. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  302. Calle P, et al. 2021. Cells. 10:. PubMed
  303. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  304. Horsle B 2013. Development. 140:1517. PubMed
  305. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  306. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  307. Gamradt P, et al. 2016. PLoS Pathog. 12:e1006032. PubMed
  308. Wang X, et al. 2016. J Immunol. 197(12):4750-4761. PubMed
  309. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  310. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  311. Kerkhofs D, et al. 2020. Theranostics. 7.022222222. PubMed
  312. Toda G, et al. 2020. Molecular Cell. 79(1):43-53.e4. PubMed
  313. Karki R, et al. 2020. bioRxiv. . PubMed
  314. Hua X, et al. 2021. Front Immunol. 12:706027. PubMed
  315. Liu J, et al. 2021. Front Immunol. 12:733808. PubMed
  316. Feng L, et al. 2022. Signal Transduct Target Ther. 7:21. PubMed
  317. Zhang MS, et al. 2022. Nat Commun. 13:954. PubMed
  318. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  319. Sun L, et al. 2009. FASEB J. 3.602777778. PubMed
  320. Esposito E, et al. 2019. Nat Commun. 4.101388889. PubMed
  321. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  322. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  323. Li K, et al. 2020. J Cell Mol Med. 24:13115. PubMed
  324. Karki R, et al. 2021. Cell. 184:149. PubMed
  325. Caoa X, et al. 2017. Neurosci Lett. 10.1016/j.neulet.2017.02.045. PubMed
  326. Jeurissen M, et al. 2016. PLoS One. 11:e0167199. PubMed
  327. Montero-Barrera D, et al. 2015. BioMed Res Int. 2015 615865. PubMed
  328. Neimert-Andersson T, et al. 2011. Vaccine. 29:8965. PubMed
  329. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  330. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  331. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  332. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  333. Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
  334. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  335. Gu H, et al. 2021. Elife. 10:. PubMed
  336. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  337. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  338. Nishino T, et al. 2018. Arterioscler Thromb Vasc Biol. 38:2460. PubMed
  339. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  340. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  341. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  342. Chan JY, et al. 2019. Diabetologia. 62:993. PubMed
  343. Mirsoian A, et al. 2014. J Exp Med. 211:2373. PubMed
  344. Yin X, et al. 2015. J Immunol. 194:4029. PubMed
  345. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  346. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  347. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  348. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  349. Adzika GK, et al. 2021. Front Cell Dev Biol. 9:719351. PubMed
  350. Karpurapu M, et al. 2011. Blood. 118:5255. PubMed
  351. Yan K, et al. 2020. Cell Death Dis. 1.013888889. PubMed
  352. Eghbalzadeh K, et al. 2019. Front Immunol. 2.022916667. PubMed
  353. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  354. Liu SS, et al. 2021. Immunity. :. PubMed
  355. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  356. Cao H, et al. 2020. Front Pharmacol. 11:578943. PubMed
  357. Ngkelo A, et al. 2016. J Exp Med. 213: 1353 - 1374. PubMed
  358. Sockolosky J, et al. 2016. Proc Natl Acad Sci U S A. 113: 2646 - 2654. PubMed
  359. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  360. Ishizuka M, et al. 2015. PLoS One. 10: 0137978. PubMed
  361. Pechous R, et al. 2015. MBio. 6:2302. PubMed
  362. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  363. Klezovich-Bénard M, et al. 2012. PLoS One. 8:e1002481. PubMed
  364. Ling X, et al. 2021. Biomaterials. 270:120690. PubMed
  365. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  366. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  367. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  368. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  369. Adzika GK, et al. 2021. Front Cardiovasc Med. 8:719805. PubMed
  370. Wang X, et al. 2021. Theranostics. 11:209. PubMed
  371. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  372. Koupenova M, et al. 2019. iScience. 19:916. PubMed
  373. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  374. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  375. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  376. Kim M, et al. 2012. J Immunol. 188:4158. PubMed
  377. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  378. Bramwell K, et al. 2015. J Immunol. 195: 1647 - 1656. PubMed
  379. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
  380. Schuijs M, et al. 2016. PLoS One. 11: 016188. PubMed
  381. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
  382. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  383. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  384. Fu W, et al. 2020. J Immunol Res. 8820355:2020. PubMed
  385. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  386. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  387. Caporarello N, et al. 2022. Nat Commun. 13:4170. PubMed
  388. Malik M, et al. 2012. Proc Natl Acad Sci U S A. 109:6130. PubMed
  389. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  390. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  391. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  392. Sparber F et al. 2019. British journal of pharmacology. 176(11):1728-1744 . PubMed
  393. Lalor R, et al. 2019. Nutrients. 11. PubMed
  394. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  395. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  396. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  397. Badgujar DC, et al. 2020. PLoS Pathog. 16:e1009016. PubMed
  398. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  399. Fearon AE, et al. 2021. iScience. 24:103143. PubMed
  400. Chung EJ, et al. 2021. Int J Radiat Oncol Biol Phys. 110:526. PubMed
  401. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  402. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  403. Liu ZZ, et al. 2021. Front Immunol. 12:636861. PubMed
RRID
AB_893493 (BioLegend Cat. No. 123115)
AB_893481 (BioLegend Cat. No. 123116)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
UniProt
View information about F4/80 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All F4/80 Reagents Request Custom Conjugation
Description Clone Applications
PE/Dazzle™ 594 anti-mouse F4/80 BM8 FC
Brilliant Violet 650™ anti-mouse F4/80 BM8 FC
Brilliant Violet 711™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 (Maxpar® Ready) BM8 FC,CyTOF®
APC/Fire™ 750 anti-mouse F4/80 BM8 FC
TotalSeq™-A0114 anti-mouse F4/80 BM8 PG
TotalSeq™-B0114 anti-mouse F4/80 BM8 PG
TotalSeq™-C0114 anti-mouse F4/80 BM8 PG
KIRAVIA Blue 520™ anti-mouse F4/80 BM8 FC
Spark YG™ 570 anti-mouse F4/80 BM8 IHC-F
Ultra-LEAF™ Purified anti-mouse F4/80 BM8 FC,IHC,WB
Brilliant Violet 605™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 BM8 FC,IHC,WB
Biotin anti-mouse F4/80 BM8 FC,IHC
FITC anti-mouse F4/80 BM8 FC
PE anti-mouse F4/80 BM8 FC
PE/Cyanine5 anti-mouse F4/80 BM8 FC
PE/Cyanine7 anti-mouse F4/80 BM8 FC
APC anti-mouse F4/80 BM8 FC
APC/Cyanine7 anti-mouse F4/80 BM8 FC
Alexa Fluor® 488 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Alexa Fluor® 647 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse F4/80 BM8 FC
PerCP anti-mouse F4/80 BM8 FC
PerCP/Cyanine5.5 anti-mouse F4/80 BM8 FC
Alexa Fluor® 700 anti-mouse F4/80 BM8 FC
Brilliant Violet 421™ anti-mouse F4/80 BM8 FC,IHC-F,SB
Brilliant Violet 510™ anti-mouse F4/80 BM8 FC
Alexa Fluor® 594 anti-mouse F4/80 BM8 IHC-F
Brilliant Violet 785™ anti-mouse F4/80 BM8 FC
APC/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark NIR™ 685 anti-mouse F4/80 BM8 FC
Spark Blue™ 550 anti-mouse F4/80 BM8 FC
Brilliant Violet 750™ anti-mouse F4/80 BM8 FC
Brilliant Violet 570™ anti-mouse F4/80 BM8 FC
PE/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark Red™ 718 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Spark Blue™ 574 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
PerCP/Fire™ 806 anti-mouse F4/80 BM8 FC
PE/Fire™ 640 anti-mouse F4/80 BM8 FC
Go To Top Version: 2    Revision Date: 10.25.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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