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Purified anti-human HVCN1 Antibody

Pricing & Availability
Clone
W23068A (See other available formats)
Regulatory Status
RUO
Other Names
HVCN1 (hydrogen voltage gated channel 1), HV1, VSOP (voltage sensor domain-only protein)
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W23068A_PURE_HVCN1_FC_073125
Human peripheral blood mononuclear cells were fixed, permeabilized and intracellularly stained with purified anti-human HVCN1 (clone W23068A) (left) or purified rat IgG2a, κ isotype control (right), followed by anti-rat IgG PE. Cells were then stained with anti-human CD19 (clone HIB19) Brilliant Violet 421™. Data shown is gated on the lymphocyte population.
  • W23068A_PURE_HVCN1_FC_073125
    Human peripheral blood mononuclear cells were fixed, permeabilized and intracellularly stained with purified anti-human HVCN1 (clone W23068A) (left) or purified rat IgG2a, κ isotype control (right), followed by anti-rat IgG PE. Cells were then stained with anti-human CD19 (clone HIB19) Brilliant Violet 421™. Data shown is gated on the lymphocyte population.
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377106 100 µg 338€
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Description

HVCN1 (hydrogen voltage-gated channel 1), is a voltage gated proton-selective channel. HVCN1 is expressed in immune cells, spermatozoa, and upper respiratory tract epithelial cells. HVCN1 mediates the proton conductance required to maintain inhibition of membrane depolarization and acidification of cytoplasm. HVCN1 is required by phagocytes for oxidative burst that underlies microbial killing and in B cells to facilitates antibody production. HVCN1 can also regulate functions in other cells including spermatozoa.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant human HVCN1
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
Transmembrane protein with four helix transmembrane domain and a coiled coil c-terminal cytoplasmic domain
Distribution

Immune cells (B-cells, Neutrophils, Monocytes), spermatozoa, upper respiratory epithelium

Function
Proton transporter
Molecular Family
Ion Channels
Antigen References
  1. Zhu X, et al. 2013. BMC Immunol. 14:24.
  2. Hondares E, et al. 2014. Proc. Natl. Acad. Sci. 111:50. 
  3. Okochi Y, et al. 2021. Int. J. Mol. Sci. 22:2620.
  4. Wang Y, et al. 2011. Biochem. Biophys. Res. Commun. 2: 412.
  5. Cherny VV, et al. 2015. J. Gen. Physiol. 5: 146.
  6. De Coursey TE. 2015. Biochemistry. 54: 21.
Gene ID
84329 View all products for this Gene ID
UniProt
View information about HVCN1 on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 07.31.2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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