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Purified anti-human IFNAR1 Antibody

Pricing & Availability
Clone
W23118A (See other available formats)
Regulatory Status
RUO
Other Names
IFRC, IFNAR, IFNBR
Isotype
Rat IgG2a, κ
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Product Citations
publications
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377137 100 µg 322€
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Description

IFNAR1 is a 64 kD transmembrane protein that forms the heterodimeric receptor for type I interferons, including IFN-α, IFN-β, IFN-κ, IFN-ω, and IFN-ε, through a non-covalent association with IFNAR2. IFNAR-1 is expressed by nearly all cell types across various tissues, including the immune, endocrine, and central nervous systems. The binding of type I interferons to the receptor activates JAK-STAT signaling pathways, which promote the expression of interferon-stimulated genes (ISGs) and mediate anti-viral activity, tumor recognition, inflammation, and T-cell responses.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human IFNAR1-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Antigen Details

Structure
Transmembrane glycoprotein, 64 kD
Distribution

IFNAR1 and IFNAR2 are coexpressed on nearly all cells.

Function
Immune Modulation and anti-viral activity
Interaction
IFNAR2
Ligand/Receptor
IFN-α, IFN-β, IFN-κ, IFN-ω, and IFN-ε
Antigen References
  1. Novick D, et al. 1994. Cell. 77:391.
  2. Yan H, et al. 1996. EMBO J. 15:1064.
Gene ID
3454 View all products for this Gene ID
UniProt
View information about IFNAR1 on UniProt.org

Related FAQs

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Go To Top Version: 1    Revision Date: 12.31.2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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