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- Clone
- 1690CT417.18.80 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- DNA repair protein RAD51 homolog 1, HsRad51, RECA, FANCR
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 648739 | 25 µg | 120€ | ||||
| 648740 | 100 µg | 304€ | ||||
RAD51 is a key protein in the homologous recombination (HR) pathway of DNA repair. Its primary function is to facilitate the search for homology and strand invasion during the repair of double-strand breaks, ensuring genomic stability. RAD51 activity is tightly regulated by post-translational modifications and interactions with accessory proteins such as BRCA2, which help load RAD51 onto single-strand DNA. Dysregulation of RAD51 is linked to cancer, since overexpression can promote resistance to chemotherapy and radiotherapy, while loss of function leads to genomic instability and predisposition to hereditary cancers (e.g., BRCA-related breast and ovarian cancer).
Product DetailsThis product was carefully developed for performance and specificity using the following products from Horizon Discovery, a Revvity company: Accell™ non-targeting siRNA (Horizon Cat. No. D-001910-10-05) and Accell™ Human RAD51 siRNA smart pool (Horizon Cat. No. E-003530-00-0050)
Product Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant fragment of human RAD51 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
KO/KD-WB – Verified
- Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
- Structure
- RAD51 is a protein of 339 amino acids in length, with an approximate molecular weight of 37 kDa.
- Distribution
-
RAD51 is mostly nuclear, but it can also be found in the cytoplasm in an inactive state before being recruited to DNA damage sites.
- Interaction
- BRCA2, PALB2, RAD52, RPA (Replication Protein A), RAD51B, RAD51C, RAD51D, XRCC2, XRCC3, p53, ATR/ATM, BARD1
- Biology Area
- Cell Biology, Cell Cycle/DNA Replication, Cell Proliferation and Viability, Chromatin Remodeling/Epigenetics, DNA Repair/Replication
- Antigen References
-
- Lopez BS. 2025. Oncogene. 44:4006.
- Hanthi YW, et al. 2024. Mol Cell. 84:3026.
- Carver A, et al. 2021. Semin Cell Dev Biol. 113:3.
- Bhattacharya D, et al. 2022. Curr Opin Pharmacol. 67:102313.
- Gene ID
- 5888 View all products for this Gene ID
- UniProt
- View information about RAD51 on UniProt.org
Related FAQs
Other Formats
View All RAD51 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-RAD51 | 1690CT417.18.80 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-RAD51
Whole cell extracts (15 µg total protein per lane) from indi...
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