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Brefeldin A Solution (1,000X) Brefeldin A Solution (1,000X)

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Regulatory Status
RUO
Other Names
BFA
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420601 1 mL DKK387
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Description

Brefeldin A (BFA) is a protein transport inhibitor commonly used to enhance intracellular cytokine staining signals by blocking transport processes during cell activation. Especially useful for the intracellular staining of cytokines, BFA leads to the accumulation of most cytokines at the Golgi Complex/Endoplasmic Reticulum (see Jung, et al., 1993). Optimal conditions for use are cell type and time-dependent. Typically, protein transport inhibitors are included during in vitro cell activation cultures for 4-24 hours prior to harvest (see references below for additional information). Brefeldin A Solution is supplied as a 1,000X solution, which should be diluted to 1X in cell culture medium.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Brefeldin A Solution is supplied as a 1000X in DMSO, which should be diluted to 1X in cell culture medium.
Concentration
5.0 mg/ml
Storage & Handling
Store the Brefeldin A Solution (1,000X) between 2°C and 8°C. Note: DMSO freezes at this temperature.
Application

ICFC - Quality tested
Recommended Usage

Dilute the 1000X solution to 1X in the tissue culture medium. It is recommended that cells are cultured with brefeldin A for ≤ 24 hours, as this can become toxic for cell viability.

Application Notes

Completely thaw the solution before use, DMSO freezes at 4°C.  We recommend aliquotting the reagent into smaller volumes to avoid repeated freeze-thawing.  

Application References
  1. O'Sullivan BJ, et al. 2006. J. Immunol. 176:7278.
  2. Fuse S, et al. 2007. J. Immunol. 178:5227.
  3. Kang YJ, et al. 2007. Nature Immunol. 8:601.
  4. Redfern CH,et al.2006.J. Clin Oncol.19:3107. PubMed
  5. Smithey MJ, et al. 2008. J. Immunol. 180:3406. PubMed
  6. Elzey BD, et al. 2008. Blood 111:38684. PubMed
  7. Nguyen KD, et al. 2008. J. Immunol. 181:5386. PubMed
  8. Miner MD, et al. 2008. Microb Pathog. 45:273. PubMed
  9. Goodridge HS, et al. 2009. J. Immunol. 182:1146. PubMed
  10. Markey KA, et al. 2009. Blood 113:5644. PubMed
  11. Wilcox RA, et al. 2009. Blood PubMed
  12. Zenaro E, et al. 2009. J. Leukoc Bio. PubMed
  13. Rozkova D, et al. 2009. Clin Immunol. 131:1. PubMed
  14. Butcher JP, et al. 2010. Clin Cancer Res. 16:2065.
  15. Boisvert M, et al. 2010. J. Virol. 84:7782. PubMed
  16. Liu WC, et al. 2010. J. Virol. 84:12011.15. Tawara I, et al. 2011. Clin Cancer Res. 17:77. PubMed
  17. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  18. Schmidt NW, et al. 2011. J. Immunol. 186:3836. PubMed
  19. Langkjaer A, et al. 2012. Clin Immunol. 145:1. PubMed
  20. Molinero LL, et al. 2012. PNAS. 109:18529. PubMed
  21. Li HW, et al. 2012. J. Immunol. 189:5572. PubMed
  22. Wang JM, et al. 2013. J. Virol. 87:4372. PubMed
  23. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  24. Wang Jm, et al. 2013. J Virol. 87:11626. PubMed
  25. Lee TH, et al. 2013. J Biol Chem. 288:32873. PubMed
  26. Shi L, et al. 2014. J. Immunol. 192:649. PubMed
  27. Bulati M, et al. 2014. Exp Gerontol. PubMed
  28. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  29. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  30. Miller ML, et al. 2014. PNAS. 111:7397. PubMed
  31. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  32. Zhou GL, et al. 2014. J Cell Sci. 127:3916. PubMed
  33. Rist MJ, et al. 2015. J Virol. 89:703. PubMed
Product Citations
  1. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  2. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  3. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  4. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  5. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  6. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  7. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  8. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  9. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  10. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  11. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  12. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  13. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  14. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  15. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  16. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  17. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  18. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  19. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  20. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  21. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  22. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  23. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  24. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  25. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  26. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  27. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  28. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  29. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  30. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  31. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  32. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  33. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  34. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  35. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  36. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  37. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  38. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  39. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  40. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  41. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  42. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  43. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  44. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  45. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  46. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  47. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  48. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  49. Chan L, et al. 2022. Cells. 12: . PubMed
  50. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  51. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  52. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  53. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  54. Zander R, et al. 2022. Immunity. 55:475. PubMed
  55. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  56. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  57. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  58. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  59. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  60. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  61. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  62. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  63. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  64. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  65. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  66. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  67. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  68. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  69. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  70. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  71. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  72. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  73. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  74. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  75. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  76. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  77. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  78. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  79. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  80. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  81. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  82. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  83. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  84. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  85. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  86. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  87. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  88. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  89. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  90. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  91. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  92. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  93. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  94. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  95. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  96. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  97. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  98. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  99. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  100. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  101. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  102. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  103. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  104. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  105. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  106. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  107. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  108. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  109. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  110. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  111. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  112. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  113. Jondle CN, et al. 2021. MBio. 12:. PubMed
  114. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  115. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  116. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  117. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  118. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  119. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  120. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  121. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  122. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  123. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  124. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  125. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  126. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  127. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  128. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  129. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  130. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  131. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  132. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  133. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  134. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  135. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  136. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  137. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  138. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  139. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  140. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  141. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  142. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  143. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  144. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  145. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  146. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  147. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  148. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  149. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  150. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  151. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  152. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  153. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  154. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  155. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  156. Harty N 2011. J Immunol. 186:3836. PubMed
  157. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  158. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  159. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  160. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  161. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  162. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  163. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  164. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  165. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  166. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  167. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  168. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  169. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  170. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  171. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  172. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  173. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  174. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  175. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  176. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  177. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  178. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  179. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  180. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  181. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  182. Ma K, et al. 2022. iScience. 25:104347. PubMed
  183. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  184. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  185. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  186. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  187. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  188. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  189. Sekine T, et al. 2020. Cell. 183:158. PubMed
  190. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  191. Guo C, et al. 2018. Immunity. 49:842. PubMed
  192. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  193. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  194. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  195. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  196. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  197. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  198. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  199. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  200. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  201. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  202. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  203. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  204. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  205. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  206. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  207. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  208. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  209. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  210. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  211. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  212. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  213. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  214. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  215. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  216. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  217. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  218. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  219. Markey K, et al. 2009. Blood. 113:5644. PubMed
  220. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  221. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  222. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  223. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  224. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  225. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  226. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  227. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  228. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  229. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  230. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  231. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  232. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  233. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  234. Rist M, et al. 2015. J Virol. 89:703. PubMed
  235. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  236. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  237. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  238. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  239. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  240. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  241. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  242. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  243. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  244. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  245. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  246. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  247. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  248. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  249. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  250. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  251. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  252. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  253. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  254. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  255. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  256. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  257. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  258. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  259. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  260. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  261. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  262. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  263. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  264. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  265. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  266. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  267. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed
  268. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  269. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  270. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  271. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  272. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  273. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  274. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  275. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  276. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  277. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  278. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  279. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  280. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  281. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  282. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  283. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  284. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  285. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  286. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  287. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  288. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  289. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  290. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  291. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  292. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  293. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  294. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  295. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  296. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  297. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  298. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  299. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  300. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  301. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  302. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  303. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  304. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  305. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  306. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  307. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  308. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  309. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  310. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  311. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  312. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  313. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  314. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  315. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  316. Chan L, et al. 2022. Cells. 12: . PubMed
  317. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  318. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  319. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  320. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  321. Zander R, et al. 2022. Immunity. 55:475. PubMed
  322. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  323. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  324. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  325. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  326. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  327. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  328. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  329. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  330. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  331. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  332. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  333. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  334. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  335. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  336. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  337. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  338. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  339. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  340. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  341. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  342. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  343. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  344. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  345. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  346. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  347. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  348. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  349. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  350. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  351. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  352. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  353. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  354. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  355. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  356. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  357. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  358. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  359. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  360. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  361. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  362. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  363. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  364. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  365. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  366. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  367. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  368. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  369. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  370. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  371. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  372. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  373. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  374. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  375. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  376. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  377. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  378. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  379. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  380. Jondle CN, et al. 2021. MBio. 12:. PubMed
  381. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  382. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  383. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  384. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  385. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  386. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  387. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  388. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  389. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  390. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  391. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  392. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  393. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  394. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  395. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  396. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  397. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  398. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  399. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  400. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  401. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  402. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  403. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  404. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  405. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  406. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  407. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  408. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  409. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  410. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  411. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  412. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  413. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  414. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  415. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  416. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  417. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  418. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  419. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  420. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  421. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  422. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  423. Harty N 2011. J Immunol. 186:3836. PubMed
  424. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  425. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  426. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  427. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  428. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  429. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  430. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  431. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  432. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  433. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  434. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  435. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  436. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  437. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  438. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  439. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  440. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  441. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  442. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  443. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  444. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  445. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  446. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  447. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  448. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  449. Ma K, et al. 2022. iScience. 25:104347. PubMed
  450. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  451. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  452. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  453. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  454. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  455. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  456. Sekine T, et al. 2020. Cell. 183:158. PubMed
  457. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  458. Guo C, et al. 2018. Immunity. 49:842. PubMed
  459. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  460. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  461. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  462. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  463. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  464. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  465. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  466. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  467. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  468. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  469. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  470. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  471. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  472. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  473. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  474. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  475. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  476. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  477. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  478. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  479. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  480. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  481. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  482. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  483. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  484. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  485. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  486. Markey K, et al. 2009. Blood. 113:5644. PubMed
  487. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  488. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  489. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  490. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  491. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  492. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  493. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  494. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  495. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  496. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  497. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  498. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  499. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  500. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  501. Rist M, et al. 2015. J Virol. 89:703. PubMed
  502. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  503. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  504. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  505. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  506. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  507. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  508. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  509. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  510. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  511. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  512. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  513. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  514. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  515. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  516. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  517. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  518. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  519. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  520. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  521. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  522. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  523. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  524. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  525. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  526. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  527. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  528. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  529. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  530. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  531. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  532. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  533. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  534. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed

Antigen Details

Antigen References

1. Current Protocols in Immunology (John Wiley & Sons New York) Unit 6.24 Detection of Intracellular Cytokines by Flow Cytometry (Barbara Foster and Calman Prussin NIAID NIH Bethesda MD).
2. Sander B, et al. 1991. Immunol. Rev. 119:65.
3. Sander B, et al. 1993. J. Immunol. Meth. 166:201.
4. Prussin C, et al. 1995. J. Immunol. Meth. 188:117.
5. Jung T, et al. 1993. J. Immunol. Meth. 159:197.

Gene ID
NA

Related FAQs

The Brefeldin A solution freezes at 4°C . Is the solution still OK?

We recommend to thaw in warm water after removing from the fridge.  The Brefeldin A is dissolved in DMSO, which freezes at 18°C, so this is normal.  No one has reported any problems with the freeze/thaw cycles and this is how we recommend it is stored.   If customers are concerned, they can aliquot the Brefeldin A to avoid the freeze thaw.

How do I choose monensin or Brefeldin A solution?

Generally, Brefeldin A is more toxic for longer term incubations, so for shorter stimulations (6 hrs or less) use Brefeldin A.  For longer stimulations use monensin.  We recommend optimization for each cell type and protocol.

Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Regulatory Status
RUO
Other Names
BFA
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Description

Brefeldin A (BFA) is a protein transport inhibitor commonly used to enhance intracellular cytokine staining signals by blocking transport processes during cell activation. Especially useful for the intracellular staining of cytokines, BFA leads to the accumulation of most cytokines at the Golgi Complex/Endoplasmic Reticulum (see Jung, et al., 1993). Optimal conditions for use are cell type and time-dependent. Typically, protein transport inhibitors are included during in vitro cell activation cultures for 4-24 hours prior to harvest (see references below for additional information). Brefeldin A Solution is supplied as a 1,000X solution, which should be diluted to 1X in cell culture medium.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Brefeldin A Solution is supplied as a 1000X in DMSO, which should be diluted to 1X in cell culture medium.
Concentration
5.0 mg/ml
Storage & Handling
Store the Brefeldin A Solution (1,000X) between 2°C and 8°C. Note: DMSO freezes at this temperature.
Application

ICFC - Quality tested
Recommended Usage

Dilute the 1000X solution to 1X in the tissue culture medium. It is recommended that cells are cultured with brefeldin A for ≤ 24 hours, as this can become toxic for cell viability.

Application Notes

Completely thaw the solution before use, DMSO freezes at 4°C.  We recommend aliquotting the reagent into smaller volumes to avoid repeated freeze-thawing.  

Application References
  1. O'Sullivan BJ, et al. 2006. J. Immunol. 176:7278.
  2. Fuse S, et al. 2007. J. Immunol. 178:5227.
  3. Kang YJ, et al. 2007. Nature Immunol. 8:601.
  4. Redfern CH,et al.2006.J. Clin Oncol.19:3107. PubMed
  5. Smithey MJ, et al. 2008. J. Immunol. 180:3406. PubMed
  6. Elzey BD, et al. 2008. Blood 111:38684. PubMed
  7. Nguyen KD, et al. 2008. J. Immunol. 181:5386. PubMed
  8. Miner MD, et al. 2008. Microb Pathog. 45:273. PubMed
  9. Goodridge HS, et al. 2009. J. Immunol. 182:1146. PubMed
  10. Markey KA, et al. 2009. Blood 113:5644. PubMed
  11. Wilcox RA, et al. 2009. Blood PubMed
  12. Zenaro E, et al. 2009. J. Leukoc Bio. PubMed
  13. Rozkova D, et al. 2009. Clin Immunol. 131:1. PubMed
  14. Butcher JP, et al. 2010. Clin Cancer Res. 16:2065.
  15. Boisvert M, et al. 2010. J. Virol. 84:7782. PubMed
  16. Liu WC, et al. 2010. J. Virol. 84:12011.15. Tawara I, et al. 2011. Clin Cancer Res. 17:77. PubMed
  17. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  18. Schmidt NW, et al. 2011. J. Immunol. 186:3836. PubMed
  19. Langkjaer A, et al. 2012. Clin Immunol. 145:1. PubMed
  20. Molinero LL, et al. 2012. PNAS. 109:18529. PubMed
  21. Li HW, et al. 2012. J. Immunol. 189:5572. PubMed
  22. Wang JM, et al. 2013. J. Virol. 87:4372. PubMed
  23. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  24. Wang Jm, et al. 2013. J Virol. 87:11626. PubMed
  25. Lee TH, et al. 2013. J Biol Chem. 288:32873. PubMed
  26. Shi L, et al. 2014. J. Immunol. 192:649. PubMed
  27. Bulati M, et al. 2014. Exp Gerontol. PubMed
  28. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  29. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  30. Miller ML, et al. 2014. PNAS. 111:7397. PubMed
  31. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  32. Zhou GL, et al. 2014. J Cell Sci. 127:3916. PubMed
  33. Rist MJ, et al. 2015. J Virol. 89:703. PubMed
Product Citations
  1. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  2. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  3. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  4. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  5. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  6. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  7. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  8. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  9. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  10. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  11. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  12. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  13. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  14. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  15. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  16. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  17. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  18. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  19. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  20. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  21. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  22. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  23. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  24. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  25. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  26. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  27. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  28. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  29. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  30. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  31. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  32. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  33. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  34. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  35. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  36. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  37. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  38. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  39. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  40. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  41. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  42. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  43. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  44. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  45. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  46. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  47. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  48. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  49. Chan L, et al. 2022. Cells. 12: . PubMed
  50. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  51. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  52. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  53. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  54. Zander R, et al. 2022. Immunity. 55:475. PubMed
  55. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  56. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  57. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  58. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  59. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  60. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  61. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  62. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  63. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  64. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  65. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  66. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  67. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  68. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  69. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  70. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  71. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  72. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  73. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  74. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  75. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  76. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  77. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  78. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  79. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  80. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  81. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  82. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  83. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  84. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  85. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  86. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  87. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  88. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  89. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  90. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  91. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  92. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  93. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  94. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  95. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  96. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  97. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  98. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  99. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  100. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  101. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  102. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  103. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  104. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  105. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  106. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  107. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  108. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  109. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  110. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  111. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  112. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  113. Jondle CN, et al. 2021. MBio. 12:. PubMed
  114. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  115. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  116. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  117. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  118. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  119. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  120. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  121. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  122. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  123. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  124. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  125. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  126. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  127. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  128. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  129. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  130. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  131. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  132. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  133. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  134. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  135. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  136. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  137. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  138. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  139. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  140. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  141. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  142. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  143. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  144. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  145. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  146. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  147. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  148. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  149. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  150. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  151. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  152. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  153. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  154. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  155. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  156. Harty N 2011. J Immunol. 186:3836. PubMed
  157. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  158. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  159. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  160. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  161. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  162. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  163. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  164. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  165. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  166. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  167. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  168. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  169. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  170. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  171. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  172. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  173. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  174. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  175. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  176. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  177. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  178. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  179. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  180. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  181. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  182. Ma K, et al. 2022. iScience. 25:104347. PubMed
  183. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  184. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  185. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  186. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  187. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  188. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  189. Sekine T, et al. 2020. Cell. 183:158. PubMed
  190. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  191. Guo C, et al. 2018. Immunity. 49:842. PubMed
  192. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  193. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  194. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  195. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  196. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  197. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  198. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  199. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  200. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  201. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  202. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  203. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  204. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  205. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  206. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  207. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  208. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  209. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  210. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  211. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  212. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  213. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  214. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  215. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  216. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  217. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  218. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  219. Markey K, et al. 2009. Blood. 113:5644. PubMed
  220. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  221. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  222. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  223. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  224. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  225. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  226. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  227. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  228. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  229. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  230. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  231. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  232. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  233. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  234. Rist M, et al. 2015. J Virol. 89:703. PubMed
  235. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  236. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  237. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  238. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  239. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  240. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  241. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  242. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  243. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  244. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  245. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  246. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  247. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  248. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  249. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  250. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  251. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  252. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  253. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  254. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  255. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  256. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  257. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  258. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  259. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  260. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  261. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  262. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  263. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  264. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  265. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  266. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  267. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed
  268. Wang Y, et al. 2014. Sci Rep. 4:5346. PubMed
  269. Morse M, et al. 2016. Lupus. 25: 81 - 87. PubMed
  270. Li B, Schmidt N 2016. PLoS One. 11: 0162427. PubMed
  271. Rappazzo CG, et al. 2020. bioRxiv. . PubMed
  272. Wang R, et al. 2018. Oncoimmunology. 7:e1461303. PubMed
  273. Sun Y, et al. 2022. STAR Protoc. 3:101479. PubMed
  274. Redelman-Sidi G, et al. 2022. Cancer Immunol Res. 10:1241. PubMed
  275. Frost JN, et al. 2022. Sci Adv. 8:eabq5384. PubMed
  276. Lao L, et al. 2023. Cancer Immunol Res. 11:320. PubMed
  277. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  278. Yang WL, et al. 2023. Nat Commun. 14:863. PubMed
  279. Wu Z, et al. 2023. EMBO Rep. 24:e56524. PubMed
  280. Li G, et al. 2023. Cell Death Dis. 14:185. PubMed
  281. Kozlovski S, et al. 2023. Front Immunol. 13:1041552. PubMed
  282. Mohammadpour H, et al. 2023. Cell Rep. 42:112250. PubMed
  283. Jung HY, et al. 2023. Oncoimmunology. 12:2190671. PubMed
  284. Li Y, et al. 2023. Vaccines (Basel). 11:. PubMed
  285. Onyshchenko K, et al. 2023. Nat Commun. 14:2087. PubMed
  286. Zhou X, et al. 2023. Sci Rep. 13:6701. PubMed
  287. Ko ES, et al. 2023. Cell Commun Signal. 21:107. PubMed
  288. Wang Y, et al. 2023. iScience. 26:106630. PubMed
  289. Thomas OG, et al. 2023. Sci Adv. 9:eadg3032. PubMed
  290. Changsheng H, et al. 2023. Sci Adv. 9:eade4186. PubMed
  291. Adamo S, et al. 2023. Cell Host Microbe. 31:928. PubMed
  292. LaPorte KM, et al. 2023. J Immunother Cancer. 11:. PubMed
  293. Patskovsky Y, et al. 2023. Nat Commun. 14:3763. PubMed
  294. Yakkala C, et al. 2021. Front Immunol. 12:695150. PubMed
  295. Zheng B, et al. 2021. Int J Mol Sci. 22: . PubMed
  296. Alexander KL, et al. 2021. Gastroenterology. 161:522. PubMed
  297. Trinks N, et al. 2021. Commun Biol. 4:1151. PubMed
  298. Chen J, et al. 2022. Adv Healthc Mater. 11:e2101714. PubMed
  299. Persaud AT, et al. 2022. J Leukoc Biol. 111:573. PubMed
  300. Yu L, et al. 2022. FEBS J. 289:3241. PubMed
  301. Ritzel RM, et al. 2022. Geroscience. 44:1407. PubMed
  302. D'Angeli V, et al. 2022. Eur J Immunol. 52:1058. PubMed
  303. Lu R, et al. 2022. Scand J Immunol. 96:e13177. PubMed
  304. Kanbar JN, et al. 2022. J Exp Med. 219: . PubMed
  305. Minichino D, et al. 2022. J Leukoc Biol. 112:1089. PubMed
  306. Gao KM, et al. 2022. Proc Natl Acad Sci U S A. 119:e2202327119. PubMed
  307. Liu H, et al. 2022. Cell Rep Med. 3:100660. PubMed
  308. Jondle CN, et al. 2022. J Virol. 96:e0063922. PubMed
  309. Blanas A, et al. 2022. iScience. 25:104719. PubMed
  310. Hsieh T, et al. 2022. Front Immunol. 13:901030. PubMed
  311. Li FL, et al. 2022. EMBO J. 41:e110698. PubMed
  312. Bates TA, et al. 2022. Cell Rep. 41:111544. PubMed
  313. Dutt TS, et al. 2022. Cell Rep. 41:111783. PubMed
  314. Phares TW, et al. 2022. Front Pharmacol. 13:1029636. PubMed
  315. Shamriz O, et al. 2023. Front Immunol. 13:1044933. PubMed
  316. Chan L, et al. 2022. Cells. 12: . PubMed
  317. Chan L, et al. 2023. Int J Mol Sci. 24: . PubMed
  318. Nanishi E, et al. 2023. NPJ Vaccines. 8:18. PubMed
  319. Hajjar S, et al. 2022. Cell Death Differ. 29:585. PubMed
  320. Li Y, et al. 2022. Brain Behav Immun. 101:1. PubMed
  321. Zander R, et al. 2022. Immunity. 55:475. PubMed
  322. Pymm P, et al. 2022. Cell Rep. 38:110449. PubMed
  323. Giles JR, et al. 2022. Immunity. 55:557. PubMed
  324. Ye L, et al. 2022. Cell Metab. 34:595. PubMed
  325. Guo H, et al. 2022. Biomaterials. 283:121441. PubMed
  326. Zhao Y, et al. 2022. ACS Appl Mater Interfaces. 14:21872. PubMed
  327. Bronge M, et al. 2022. Sci Adv. 8:eabn1823. PubMed
  328. Qian Y, et al. 2021. Cell Reports. 36(8):109602. PubMed
  329. Pablo-Bernal R, et al. 2016. J Gerontol A Biol Sci Med Sci. 71: 610 - 618. PubMed
  330. Tuna H, et al. 2014. J Leukoc Biol. 95:471. PubMed
  331. Zhu S, et al. 2017. Exp Cell Res.. 10.1016/j.yexcr.2017.10.013. PubMed
  332. Li L,et al. 2017. Sci Rep.. 10.1038/s41598-017-14000-z. PubMed
  333. Xin G, et al. 2021. Cancer Immunol Res. 9:454. PubMed
  334. Rodrigues M, et al. 2022. Biochem J. 479:1891. PubMed
  335. Nesterenko PA, et al. 2021. Cell Rep. 37:110167. PubMed
  336. Lefebvre MN, et al. 2021. Cell Rep. 37:109956. PubMed
  337. Muliaditan T, et al. 2021. Cell Rep Med. 2:100457. PubMed
  338. Fote GM, et al. 2022. J Cell Sci. 135:. PubMed
  339. Aguilar-Pineda JA, et al. 2021. iScience. 24:102993. PubMed
  340. Moudra A, et al. 2021. J Immunol. 206:2109. PubMed
  341. Shi L, et al. 2014. J Immunol. 192:649. PubMed
  342. Maschmeyer P, et al. 2017. J Autoimmun.. 10.1016/j.jaut.2017.11.005. PubMed
  343. Yamamoto A, et al. 2019. J Clin Invest. 129:3640. PubMed
  344. Weng RR, et al. 2021. Nat Commun. 12:2163. PubMed
  345. Kiritsy MC, et al. 2021. Elife. 10:. PubMed
  346. Gay MD, et al. 2020. Cancer Prev Res (Phila). . PubMed
  347. Just S, et al. 2016. Sci Rep. 6:39796. PubMed
  348. Piper CJM, et al. 2020. Cell Reports. 29(7):1878-1892.e7.. PubMed
  349. Liang Q, et al. 2022. iScience. 25:104043. PubMed
  350. Cook CP, et al. 2022. Cell Rep Med. 3:100715. PubMed
  351. Snyder LM, et al. 2021. PLoS Pathog. 17:e1009970. PubMed
  352. Krone A, et al. 2022. Sci Rep. 218:. PubMed
  353. Michaud D, et al. 2022. Front Immunol. 12:745873. PubMed
  354. Nagatake T, et al. 2022. Mucosal Immunol. 15:289. PubMed
  355. Starnbach X 2015. J Immunol. 195: 1665-1675. PubMed
  356. Garg B, et al. 2016. Mutagenesis. 10.1093/mutage/gew023. PubMed
  357. Ruhland M, et al. 2016. Nat Commun. 7:11762. PubMed
  358. Shi Z, et al. 2021. Ann Clin Transl Neurol. 8:43. PubMed
  359. Tang B, et al. 2020. Clin Cancer Res. 26:2216. PubMed
  360. Jtte BB, et al. 2021. iScience. 24(8):102833. PubMed
  361. Nguyen K, et al. 2008. J Immunol. 181:5386. PubMed
  362. Wilcox R, et al. 2009. Blood. 114:2936. PubMed
  363. Almshayakhchi R, et al. 2021. Front Oncol. 11:636977. PubMed
  364. Glaubitz J, et al. 2022. Nat Commun. 13:4502. PubMed
  365. Martens A, et al. 2020. Nat Immunol. 21:381. PubMed
  366. Wang Z, et al. 2020. Autophagy. 1:. PubMed
  367. Jiang S, et al. 2020. Scand J Immunol. e12867:91. PubMed
  368. Hradilova N, et al. 2017. PLoS One. 12(2):e0171539. PubMed
  369. Griffiths K, et al. 2016. Nat Commun. 7:13894. PubMed
  370. Ciarlo E, et al. 2016. Sci Rep. 6:37944. PubMed
  371. Al-Attar A, et al. 2016. Data Brief. 8: 536-44. PubMed
  372. Gonzalez-Perez G, et al. 2016. J Immunol. 196: 3768 - 3779. PubMed
  373. Pablo-Bernal R, et al. 2015. J Infect Dis. 10.1093/infdis/jiv520. PubMed
  374. Blankenhaus B, et al. 2014. PLoS Pathog. 10:1003913. PubMed
  375. Smithey M, et al. 2008. J Immunol. 180:3406. PubMed
  376. Rana A, et al. 2020. Front Immunol. 11:536. PubMed
  377. Dayoub O, et al. 2017. Sci Rep. 10.1038/s41598-017-09933-4. PubMed
  378. Kang X, et al. 2022. Vaccines (Basel). 10:. PubMed
  379. Jeong J, et al. 2021. Immune Netw. 21:e31. PubMed
  380. Jondle CN, et al. 2021. MBio. 12:. PubMed
  381. Doll K, et al. 2016. J Immunol. 196: 4253 - 4262. PubMed
  382. Liu W, et al. 2016. J Virol. 90: 6085 - 6096. PubMed
  383. Fucikova J, et al. 2016. Blood. 128(26):3113-3124. PubMed
  384. Douthwaite J, et al. 2017. J Immunol. 198(1):528-537. PubMed
  385. Yu H, et al. 2011. J Leukoc Biol. 90:205. PubMed
  386. Snyder LM, et al. 2022. Immunohorizons. 6:660. PubMed
  387. Zhao F, et al. 2022. Front Immunol. 13:873720. PubMed
  388. Rialdi A, et al. 2016. Science. 352: aad7993. PubMed
  389. Li H, et al. 2012. J Immunol. 189:5572. PubMed
  390. Liu W, et al. 2010. J Virol. 84:12011. PubMed
  391. Elzey B, et al. 2008. Blood. 111:3684. PubMed
  392. Ries M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006506. PubMed
  393. Satoh M, et al. 2016. Sci Rep. 6:28473. PubMed
  394. Codo AC, et al. 2020. Cell Metab. 32:437. PubMed
  395. Carissimo G, et al. 2019. Life Sci Alliance. 2:e201900298. PubMed
  396. Wang Y, et al. 2020. Sci Adv. 6:eaba5412. PubMed
  397. Littwitz-Salomon E, et al. 2021. Nat Commun. 12:5376. PubMed
  398. Shenoy AT, et al. 2021. Nat Commun. 12:5834. PubMed
  399. Ulrich-Lewis JT, et al. 2022. Front Immunol. 13:861710. PubMed
  400. Elliott PR, et al. 2021. Cell Rep. 37:109777. PubMed
  401. Dumaine JE, et al. 2021. Elife. 10:. PubMed
  402. Cheng B, et al. 2022. Cancer Commun (Lond). 42:17. PubMed
  403. Jondle CN, et al. 2021. J Virol. 95:e0072621. PubMed
  404. Bunting MD, et al. 2022. Sci Adv. 8:eabk3327. PubMed
  405. Uddin MN, et al. 2022. Brain Behav Immun Health. 26:100563. PubMed
  406. Gross C, et al. 2016. Neurol Neuroimmunol Neuroinflamm. 3: e289. PubMed
  407. Krämer B, et al. 2016. PLoS One. 11: 0162068. PubMed
  408. Tawara I, et al. 2011. Clin Cancer Res. 0.761805556. PubMed
  409. Orlov M, et al. 2017. PLoS One.. 10.1371/journal.pone.018296. PubMed
  410. Martins M, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006529. PubMed
  411. Crooks SD, et al. 2022. Immunohorizons. 6:705. PubMed
  412. Fang E, et al. 2022. MedComm (2020). 3:e117. PubMed
  413. Lee T, et al. 2013. J Biol Chem. 288:32873. PubMed
  414. Vigano S, et al. 2015. J Virol. 89: 7829-7840. PubMed
  415. Vacaflores A, et al. 2016. PLoS One. 11: 0157175. PubMed
  416. Ma H, Wan S, Xia C 2016. J Leukoc Biol. 99: 1121 - 1129. PubMed
  417. Kim J, et al. 2016. Nat Immunol. 17:1159-1166. PubMed
  418. Johnson AM, et al. 2020. J Immunol. 204:2295. PubMed
  419. Buqué A, et al. 2020. Nat Commun. 3.110416667. PubMed
  420. Cao Y, et al. 2018. Nat Commun. 2.940972222. PubMed
  421. Emmer BT, et al. 2018. Elife. 7:e38839. PubMed
  422. Hassan AO, et al. 2020. Cell. 183:169. PubMed
  423. Harty N 2011. J Immunol. 186:3836. PubMed
  424. Iwata Y, et al. 2011. Blood. 117:530. PubMed
  425. Yan H, et al. 2020. ACS Appl Mater Interfaces. 12:19324. PubMed
  426. Matisz C, et al. 2017. Sci Rep. 7:40631. PubMed
  427. Castro I, et al. 2016. J Virol. 90: 5280 - 5291. PubMed
  428. Zhang W, et al. 2015. Infect Immun . 83: 3213-3223. PubMed
  429. Ji L, et al. 2012. PLoS One. 7:e50909. PubMed
  430. Redfern C, et al. 2006. J Clin Oncol. 24:3107. PubMed
  431. Huang RS, et al. 2021. Curr Protoc. 1:e246. PubMed
  432. Li G, et al. 2021. Curr Protoc. 1:e50. PubMed
  433. Gao Y, et al. 2022. Immunity. 55:1732. PubMed
  434. Han K, et al. 2021. Nat Metab. 3:318. PubMed
  435. Peng L, et al. 2022. Cell Rep Med. 3:100634. PubMed
  436. Bachy S, et al. 2022. iScience. 25:103758. PubMed
  437. Ohtsuka J, et al. 2021. iScience. Online ahead of print. PubMed
  438. Wang J, et al. 2013. J Virol. 87:4372. PubMed
  439. Nice T, et al. 2016. PLoS One. 12: 1005684. PubMed
  440. Pfeifle R, et al. 2016. Nat Immunol. 18:104-113. PubMed
  441. Krishnan A, et al. 2020. Am J Pathol. 190:1284. PubMed
  442. Ngwenyama N, et al. 2019. JCI Insight. 4:e125527. PubMed
  443. Good Z, et al. 2019. Nat Biotechnol. 37:259. PubMed
  444. Butchar J, et al. 2010. Clin Cancer Res. 2.100694444. PubMed
  445. Hiza H, et al. 2021. Sci Rep. 11:13190. PubMed
  446. Grace PS, et al. 2021. Front Immunol. 12:679973. PubMed
  447. Li Y, et al. 2021. Vaccines (Basel). 9:. PubMed
  448. Liu W, et al. 2022. Bio Protoc. 12:e4285. PubMed
  449. Ma K, et al. 2022. iScience. 25:104347. PubMed
  450. Zhang Y, et al. 2022. Vaccines (Basel). 10: . PubMed
  451. Wang Y, et al. 2020. Virol Sin. 36:122. PubMed
  452. Loeuillard E, et al. 2020. J Clin Invest. 130:5380. PubMed
  453. Matsushita T, et al. 2015. Rheumatology. 101093/rumatology/kv331. PubMed
  454. Molinero L, et al. 2012. Proc Natl Acad Sci U S A. 109:18529. PubMed
  455. Kalafati L, et al. 2020. Cell. 183:771. PubMed
  456. Sekine T, et al. 2020. Cell. 183:158. PubMed
  457. Gogokhia L, et al. 2019. Cell Host Microbe. 25:285. PubMed
  458. Guo C, et al. 2018. Immunity. 49:842. PubMed
  459. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  460. Rossato C, et al. 2017. Biologicals. 10.1016/j.biologicals.2017.06.007. PubMed
  461. Tajima M, et al. 2022. Curr Protoc. 2:e540. PubMed
  462. de Picciotto S, et al. 2022. Nat Commun. 13:3866. PubMed
  463. Michelozzi IM, et al. 2022. STAR Protoc. 3:101174. PubMed
  464. Teh MR, et al. 2021. Front Immunol. 12:714613. PubMed
  465. Stepanova E, et al. 2021. Microorganisms. 9:. PubMed
  466. Langkjær A, et al. 2012. Clin Immunol. 145:1. PubMed
  467. Rozková D, et al. 2009. Clin Immunol. 131:1. PubMed
  468. Miner M, et al. 2008. Microb Pathog. 45:273. PubMed
  469. Miller M, et al. 2014. Proc Natl Acad Sci U S A. 111:7397. PubMed
  470. Gartlan K, et al. 2015. Blood. 126: 1609-1620. PubMed
  471. Ulland T, et al. 2016. Nat Commun. 7:13180. PubMed
  472. Melacarne A, et al. 2021. Cell Reports. 36(1):109312. PubMed
  473. Raju S, et al. 2020. Cell Reports. 29(9):2556-2564.e3.. PubMed
  474. Rosser EC, et al. 2020. Cell Metabolism. 31(4):837-851. PubMed
  475. Zenaro E, et al. 2009. J Leukoc Biol. 86:1393. PubMed
  476. Goodridge H, et al. 2009. J Immunol. 182:1146. PubMed
  477. Gnerlich J, et al. 2010. J Immunol. 185:4063. PubMed
  478. Boisvert M, et al. 2010. J Virol. 84:7782. PubMed
  479. Tse SW, et al. 2021. Mol Ther. 29:2227. PubMed
  480. Cérbulo-Vázquez A, et al. 2022. PLoS One. 17:e0264566. PubMed
  481. Theisen U, et al. 2020. J Cell Biol. :219. PubMed
  482. Dáňová K, et al. 2017. J Immunol. 198(2):729-740. PubMed
  483. Beyaz S, et al. 2016. Nat Immunol. 18:184-195. PubMed
  484. Kadivar M, et al. 2016. J Immunol. 197(12):4584-4592. PubMed
  485. Wang J, et al. 2013. J Virol. 87:11262. PubMed
  486. Markey K, et al. 2009. Blood. 113:5644. PubMed
  487. Salazar V, et al. 2019. Cell Rep. 26:1585. PubMed
  488. Zischke J, et al. 2017. PLoS Pathogens. 13(6):e1006454. PubMed
  489. Ma Q, et al. 2022. Vaccines (Basel). 10:. PubMed
  490. Rhoades NS, et al. 2022. Cell Rep. 39:110725. PubMed
  491. Reuschl AK, et al. 2022. Cell Rep. 39:110650. PubMed
  492. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  493. Li Z, et al. 2021. JCI Insight. 6:. PubMed
  494. Virtakoivu R, et al. 2021. Clin Cancer Res. 27:4205. PubMed
  495. Koschel J, et al. 2021. Cell Death Differ. 28:2257. PubMed
  496. FitzPatrick MEB, et al. 2021. Cell Rep. 34:108661. PubMed
  497. Bass VL, et al. 2021. Mol Syst Biol. 17:e10127. PubMed
  498. Fukuoka A, et al. 2013. Int Immunol. 25:373. PubMed
  499. Bulati M, et al. 2014. Exp Gerontol. 54:123. PubMed
  500. Zhou G, et al. 2014. J Cell Sci. 127:3916. PubMed
  501. Rist M, et al. 2015. J Virol. 89:703. PubMed
  502. Hoechst B, et al. 2016. J Immunol. 195:1517-1523. PubMed
  503. Festag J, et al. 2020. Mol Ther Nucleic Acids. 1.330555556. PubMed
  504. Mohammadpour H, et al. 2020. JCI Insight. 5:00. PubMed
  505. Landi A, et al. 2017. Vaccine.. 10.1016/j.vaccine.2017.10.072. PubMed
  506. Gussarow D, et al. 2021. Front Med (Lausanne). 8:770381. PubMed
  507. Kohn M, et al. 2021. Front Immunol. 626627:12. PubMed
  508. Bonavita E, et al. 2020. Immunity. 1215:53. PubMed
  509. Mackroth M, et al. 2016. PLoS Pathog. 12:e1005909. PubMed
  510. Rau M, et al. 2016. J Immunol. 196: 97 - 105. PubMed
  511. Gebremeskel S, et al. 2017. Cancer Immunol Res. 0.9625. PubMed
  512. Olafsdottir TA, et al. 2022. Commun Biol. 5:914. PubMed
  513. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  514. van Loon K, et al. 2022. Cancers (Basel). 14:. PubMed
  515. Genardi S, et al. 2020. Front Immunol. 11:610010. PubMed
  516. Wang F, et al. 2021. Neoplasia. 23:281. PubMed
  517. Krishna B, et al. 2016. Sci Rep. 6: 24674. PubMed
  518. Schridde A, et al. 2017. Mucosal Immunol. 10.1038/mi.2016.142. PubMed
  519. Wang W, et al. 2020. STAR Protoc. 1:100218. PubMed
  520. Ruland C, et al. 2017. Brain Behav Immun. 10.1016/j.bbi.2017.06.010. PubMed
  521. Ahmadi H,et al. 2017. Inflammopharmacology. . 10.1007/s10787-017-0410-8. PubMed
  522. Li J, et al. 2018. Redox Biol. 0.976388889. PubMed
  523. Spiljar M, et al. 2021. Cell Metab. 33:2231. PubMed
  524. Laczkó D, et al. 2020. Immunity. 53:724. PubMed
  525. Abshire C, et al. 2016. PLoS Pathog. 12:e1006088. PubMed
  526. Ikebuchi R, et al. 2016. Sci Rep. 6:35002. PubMed
  527. Lu G, et al. 2017. PLoS One. 12:e0178352. PubMed
  528. Orozco SL, et al. 2019. Cell Rep. 28:2275. PubMed
  529. Ying B, et al. 2022. Sci Transl Med. 14:eabm3302. PubMed
  530. Guo Z, et al. 2022. Neurobiol Pain. 12:100096. PubMed
  531. Carrion B, et al. 2021. Neurol Neuroimmunol Neuroinflamm. 8:. PubMed
  532. Petrova T, et al. 2021. FEBS J. 288:5909. PubMed
  533. Nesterenko PA, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  534. Matei DE, et al. 2021. Med (N Y). 2:864. PubMed

Antigen Details

Antigen References

1. Current Protocols in Immunology (John Wiley & Sons New York) Unit 6.24 Detection of Intracellular Cytokines by Flow Cytometry (Barbara Foster and Calman Prussin NIAID NIH Bethesda MD).
2. Sander B, et al. 1991. Immunol. Rev. 119:65.
3. Sander B, et al. 1993. J. Immunol. Meth. 166:201.
4. Prussin C, et al. 1995. J. Immunol. Meth. 188:117.
5. Jung T, et al. 1993. J. Immunol. Meth. 159:197.

Gene ID
NA

Related FAQs

The Brefeldin A solution freezes at 4°C . Is the solution still OK?

We recommend to thaw in warm water after removing from the fridge.  The Brefeldin A is dissolved in DMSO, which freezes at 18°C, so this is normal.  No one has reported any problems with the freeze/thaw cycles and this is how we recommend it is stored.   If customers are concerned, they can aliquot the Brefeldin A to avoid the freeze thaw.

How do I choose monensin or Brefeldin A solution?

Generally, Brefeldin A is more toxic for longer term incubations, so for shorter stimulations (6 hrs or less) use Brefeldin A.  For longer stimulations use monensin.  We recommend optimization for each cell type and protocol.

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