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PE anti-mouse/human CD11b Antibody

Pricing & Availability
Clone
M1/70 (See other available formats)
Regulatory Status
RUO
Other Names
αM integrin, Mac-1, Mo1, CR3, Ly-40, C3biR, ITGAM
Isotype
Rat IgG2b, κ
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M170_PE_042706
C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_042706
    C57BL/6 mouse bone marrow cells were stained with CD11b (clone M1/70) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram) (gated on total cells).
  • M170_PE_CD11b_Antibody_IHC_031413
    Fixed whole mount mouse spleen was stained with Alexa Fluor® 488 F4/80 (red) (clone BM8), Brilliant Violet 421™ CD3ε (green) (clone 145-2C11), and PE CD11b (blue) (clone M1/70). Isotype controls at the same concentrations were used for the negative control. Cells were mounted in Prolong Gold and imaged with a Leica SP8 confocal. Image courtesy of Grzegorz Chodaczek and Zbigniew Mikulski at LIAI.
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101207 50 µg 45€
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101208 200 µg 139€
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Description

CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse, Human, Cynomolgus, Rhesus
Reported Reactivity
Chimpanzee, Baboon, Rabbit
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
C57BL/10 splenocytes
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/mL
Storage & Handling
The CD11b antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
IHC - Verified
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone M1/70 has been verified for immunocytochemistry (ICC) and frozen immunohistochemistry (IHC-F).

Additional reported applications (for relevant formats of this clone) include: immunoprecipitation1,4, in vitro blocking3,9,12, depletion2,8, immunofluorescence microscopy6,7,10, immunohistochemistry of acetone-fixed frozen sections5,11-13, and spatial biology (IBEX)35,36. For in vivo studies or highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) (Cat. No. 101248).

Additional Product Notes

View more applications data for this product in our Scientific Poster Library.

Application References
  1. Springer T, et al. 1978. Eur. J. Immunol. 8:539. (IP)
  2. Ault K and Springer T. 1981. J. Immunol. 126:359. (Deplete)
  3. Springer TA, et al. 1982. Immunol. Rev. 68:171. (Block)
  4. Ho MK and Springer TA. 1983. J. Biol. Chem. 258:2766. (IP)
  5. Flotte TJ, et al. 1983. Am. J. Pathol. 111:112. (IHC)
  6. Noel GJ, et al. 1990. J. Clin. Invest. 85:208. (IF)
  7. Allen LA and Aderem A. 1996. J. Exp. Med. 184:627 (IF)
  8. D'Amico A and Wu L. 2003. J. Exp. Med. 198:293. (Deplete)
  9. Brickson SJ, et al. 2003. Appl Physiol. 95:969. (Block)
  10. Clatworthy MR and Smith KG. 2004. J. Exp. Med. 199:717. (IF)
  11. Hata H, et al. 2004. J. Clin. Invest. 114:582. (IHC)
  12. Zhang Y, et al. 2002. J. Immunol. 168:3088. (IHC)
  13. Iwasaki A and Kelsall BL. 2001. J. Immunol. 166:4884 (IHC, FC)
  14. Tailleux L. 2003. J. Exp. Med. 197:121. (Block, FC)
  15. Olver S, et al. 2006. Cancer Research 66:571. (FC)
  16. Tan SL, et al. 2006. J. Immunol. 176:2872. (FC) PubMed
  17. Ponomarev ED, et al. 2006. J. Immunol. 176:1402. (FC)
  18. Dzhagalov I, et al. 2007. Blood 109:1620. (FC)
  19. Fazilleau N, et al. 2007. Nature Immunol. 8:753.
  20. Rasmussen JW, et al. 2006. Infect. Immun.74:6590. PubMed
  21. Napimoga MH, et al. 2008. J. Immunol. 180:609. PubMed
  22. Elqaraz-Carmon V, et al. 2008. J. Lipid. Res. 49:1894. PubMed
  23. Kim DD, et al. 2008. Blood 112:1109. PubMed
  24. Guo Y, et al. 2008. Blood 112:480. PubMed
  25. Norian LA, et al. 2009. Cancer Res. 69:3086. (FC) PubMed
  26. Baumgartner CK, et al. 2010. J. Immunol. 184:573. PubMed
  27. Charles N, et al. 2010. Nat. Med. 16:701. (FC) PubMed
  28. Whiteland J, et al. 1995. J. Histochem. Cytochem. 43:313. (IHC)
  29. Weber GF, et al. 2014. J Exp Med. 211:1243. PubMed
  30. Ashok A, et al. 2015. Toxicol Sci. 143:64. PubMed
  31. Price PJ, et al. 2015. J Immunol. 194:1164. PubMed
  32. Doni A, et al. 2015. J Exp Med. 212:905. PubMed
  33. Ferreira R, et al. 2016. J Infect Dis. 213: 669 - 673. PubMed
  34. Peterson VM, et al. 2017. Nat. Biotechnol. 35:936. (PG)
  35. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  36. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Guo H, Cooper S, Friedman A, et al. 2017. PLoS One. 10.1371/journal.pone.0150809. PubMed
  2. Kisielow J, et al. 2019. Nat Immunol. 1.286111111. PubMed
  3. Li A, et al. 2020. Oncol Lett. 1.899305556. PubMed
  4. Ho YH, et al. 2019. Cell Stem Cell. 25:407. PubMed
  5. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  6. Yates AG, et al. 2021. J Neuroinflammation. 18:15. PubMed
  7. Witherel CE, et al. 2021. Biomaterials. 269:120667. PubMed
  8. DeBuque RJ, et al. 2022. Dev Dyn. 251:988. PubMed
  9. He D, et al. 2022. Immunity. 55:159. PubMed
  10. Koenig A, et al. 2022. Front Immunol. 12:791100. PubMed
  11. Shang SQ, et al. 2022. Neoplasma. 69:755. PubMed
  12. Tan YY, et al. 2022. Bio Protoc. 12:e4307. PubMed
  13. Wemlinger SM, et al. 2022. J Immunol. 208:1566. PubMed
  14. Li Y, et al. 2022. J Exp Clin Cancer Res. 41:128. PubMed
  15. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  16. Yue Y, et al. 2022. Nat Biomed Eng. 6:898. PubMed
  17. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  18. Blanco LP, et al. 2022. Arthritis Rheumatol. 74:1971. PubMed
  19. Albayrak E, et al. 2022. J Cell Biochem. 123:2009. PubMed
  20. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  21. Kraemer AN, et al. 2022. Front Immunol. 13:933191. PubMed
  22. McNamara NB, et al. 2023. Nature. 613:120. PubMed
  23. Sundarasivarao PYK, et al. 2022. Front Immunol. 13:1011944. PubMed
  24. Morrow RJ, et al. 2022. Cells. 11: . PubMed
  25. Ullah I, et al. 2023. Cell Rep Med. 4:100893. PubMed
  26. Pavliuchenko N, et al. 2023. Front Immunol. 13:1035226. PubMed
  27. Marritt KL, et al. 2023. Front Immunol. 13:1087991. PubMed
  28. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  29. Zhao M, et al. 2023. J Nanobiotechnology. 21:50. PubMed
  30. Wang L, et al. 2023. Oxid Med Cell Longev. 2023:6480848. PubMed
  31. Citro A, et al. 2023. Nat Commun. 14:878. PubMed
  32. Kodali S, et al. 2022. J Immunol. 208:1085. PubMed
  33. Tang Y, et al. 2022. Dev Cell. 57:480. PubMed
  34. Marsh SE, et al. 2022. Nat Neurosci. 25:306. PubMed
  35. Ajay AK, et al. 2022. Cell Rep. 38:110473. PubMed
  36. Friedman D, et al. 2022. J Immunol. 208:1845. PubMed
  37. Ramdas B, et al. 2022. Mol Ther. 30:2505. PubMed
  38. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  39. Sauter M, et al. 2022. STAR Protoc. 3:101664. PubMed
  40. Glorieux C, et al. 2022. J Adv Res. 40:109. PubMed
  41. Krasniewski LK, et al. 2022. Elife. 11:. PubMed
  42. Wu Q, et al. 2023. Front Immunol. 13:1081719. PubMed
  43. Suzuki Y, et al. 2023. Front Immunol. 14:1089905. PubMed
  44. Zhang L, et al. 2023. Commun Biol. 6:211. PubMed
  45. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  46. Sang H, et al. 2023. Adv Clin Exp Med. 32:551. PubMed
  47. Ma X, et al. 2023. Nat Commun. 14:1606. PubMed
  48. Mascarau R, et al. 2023. J Cell Biol. 222:. PubMed
  49. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  50. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  51. Petenkova A, et al. 2023. Nat Commun. 14:2761. PubMed
  52. Xu J, et al. 2023. Discov Oncol. 14:68. PubMed
  53. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  54. Li M, et al. 2023. BMC Cancer. 23:497. PubMed
  55. Zhao C, et al. 2023. NPJ Regen Med. 8:29. PubMed
  56. Kuo PC, et al. 2021. Brain Commun. 3:fcab187. PubMed
  57. Zhao D, et al. 2021. Innate Immun. 27:533. PubMed
  58. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  59. Nigam S, et al. 2020. Mol Imaging Biol. 22:685. PubMed
  60. Hu K, et al. 2022. J Extracell Vesicles. 11:e12199. PubMed
  61. Chida J, et al. 2020. PLoS Pathog. 16:e1008823. PubMed
  62. Guo Y, et al. 2021. Exp Ther Med. 353:21. PubMed
  63. Grigsby SM, et al. 2021. Cancers (Basel). 13:. PubMed
  64. Lei G, et al. 2016. Antimicrob Agents Chemother. 60: 1289 - 1297. PubMed
  65. Viny AD, et al. 2019. Cell Stem Cell. 25:682. PubMed
  66. Jones NM, et al. 2019. BMC Cancer. 1.127777778. PubMed
  67. Wu N, et al. 2020. Cell Rep. 30:1129. PubMed
  68. Bhatt K, et al. 2018. mSphere. 3:e00352. PubMed
  69. Baryawno N et al. 2019. Cell. 177(7):1915-1932 . PubMed
  70. Abels ER et al. 2019. Cell Rep. 28(12):3105-3119 . PubMed
  71. Paris J et al. 2019. Cell Stem Cell. 25(1):137-148 . PubMed
  72. Prajeeth C,et al. 2017. J Neuroinflammation.. 10.1186/s12974-017-0978-3. PubMed
  73. Schloss MJ, et al. 2022. Nat Immunol. 23:605. PubMed
  74. Yan F, et al. 2022. Cancer Discov. 12:792. PubMed
  75. Lee S, et al. 2021. JCI Insight. 6:. PubMed
  76. Zhao X, et al. 2022. Front Mol Biosci. 9:786864. PubMed
  77. Deng Y, et al. 2021. Acta Pharmacol Sin. 42:149. PubMed
  78. Pan J, et al. 2021. Mol Ther Nucleic Acids. 26:970. PubMed
  79. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  80. Xiao X, et al. 2020. J Hematol Oncol. 0.597222222. PubMed
  81. Elkabets M, et al. 2009. J Immunol. 182:4874. PubMed
  82. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  83. Yamauchi T et al. 2018. Cancer cell. 33(3):386-400 . PubMed
  84. Sauter M, et al. 2022. iScience. 25:103677. PubMed
  85. Conforti A, et al. 2021. PLoS One. 16:e0259894. PubMed
  86. Götz P, et al. 2022. Int J Mol Sci. 23:. PubMed
  87. Adachi Y, et al. 2022. Nat Commun. 13:5117. PubMed
  88. Zhang Y, et al. 2020. Oncol Lett. 1.053472222. PubMed
  89. Dumas SJ, et al. 2021. STAR Protocols. 2(3):100523. PubMed
  90. Zhang Z, et al. 2020. J Immunol. 204:3400. PubMed
  91. Coppo M, et al. 2016. Nat Commun. 7:12254. PubMed
  92. Wang X, et al. 2016. PLoS Pathog. 12: 1005367. PubMed
  93. Hiraishi Y, et al. 2018. Sci Rep. 8:18052. PubMed
  94. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  95. Llewellyn GN, et al. 2018. J Neurovirol. 24:192. PubMed
  96. Sun Y et al. 2018. Cancer cell. 34(4):643-658 . PubMed
  97. Shears RK, et al. 2020. J Allergy Clin Immunol. 145:1272. PubMed
  98. Chen X, et al. 2021. Cell Death Differ. 28:1237. PubMed
  99. Stolp B, et al. 2022. Cell Rep. 38:110387. PubMed
  100. Craver BM, et al. 2020. Blood Adv. 4:312. PubMed
  101. Forte E, et al. 2020. J Cell Mol Med. . PubMed
  102. Earnest JT, et al. 2021. Cell Reports. 35(1):108962. PubMed
  103. Jard T, et al. 2020. Cell Stem Cell. 27(4):646-662.e7. PubMed
  104. Forte D, et al. 2020. Cell Metab. 32:829. PubMed
  105. Price J, et al. 2015. Diabetes. 64: 3521 - 3531. PubMed
  106. LaFleur MW, et al. 2019. Nat Immunol. 20:1335. PubMed
  107. Tsuchiya N, et al. 2020. Cell Reports. 29(1):162-175.e9.. PubMed
  108. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  109. Turkowski K, et al. 2017. Glia. 10.1002/glia.23234. PubMed
  110. Wiese A, et al. 2017. PLoS One. 10.1371/journal.pone.0184956. PubMed
  111. Hengyou Weng et al. 2018. Cell stem cell. 22(2):191-205 . PubMed
  112. Nakagawa S et al. 2017. Cell host & microbe. 22(5):667-677 . PubMed
  113. Swidergall M, et al. 2019. Cell Rep. 28:423. PubMed
  114. Ganeshan K et al. 2019. Cell. 177(2):399-413 . PubMed
  115. Wang Y, et al. 2022. Acta Pharm Sin B. 12:262. PubMed
  116. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  117. Chen F, et al. 2022. Evid Based Complement Alternat Med. 2022:1240242. PubMed
  118. Xu F, et al. 2022. Cell Death Discov. 8:142. PubMed
  119. Kalucka J, et al. 2020. Cell. 764:180. PubMed
  120. Joseph R, et al. 2021. Br J Cancer. 125:176. PubMed
  121. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  122. Diao N, et al. 2016. Sci Rep. 6:34672. PubMed
  123. Huang L, et al. 2016. J Biol Chem. 291: 6232 - 6244. PubMed
  124. Sharma S, et al. 2015. J Immunol. 194:5529. PubMed
  125. Pan J, et al. 2020. J Neuroinflammation. 17:97. PubMed
  126. Paraiso HC, et al. 2018. J Neuroinflammation. 0.694444444. PubMed
  127. Pan W et al. 2017. Immunity. 47(2):284-297 . PubMed
  128. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  129. Hammond TR, et al. 2019. Immunity. 50:253. PubMed
  130. Wang C, et al. 2017. J Immunol. 10.4049/jimmunol.1700671. PubMed
  131. Li K, et al. 2022. J Immunother Cancer. 10:. PubMed
  132. Hongu T, et al. 2022. Nat Cancer. 3:486. PubMed
  133. Rogawski DS, et al. 2021. Nat Commun. 12:2792. PubMed
  134. Trenevska I, et al. 2021. PLoS One. 16:e0249967. PubMed
  135. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  136. Zhang Z, et al. 2021. Oncoimmunology. 10:1912472. PubMed
  137. Haugh KA, et al. 2021. eLife. 0.416666666666667. PubMed
  138. Perner C, et al. 2020. Immunity. 53(5):1063-1077.e7. PubMed
  139. Endo Y, et al. 2020. FASEB J. 34:16086. PubMed
  140. Xiao Z, et al. 2015. Cancer Lett. 360:302. PubMed
  141. Nakaya M, et al. 2017. J Clin Invest. 127:383. PubMed
  142. Mayo L, et al. 2008. J Immunol. 181:92. PubMed
  143. An J,et al. 2017. Sci Rep.. 10.1038/s41598-017-13629-0. PubMed
  144. Wang L, et al. 2017. Front Immunol.. 10.3389/fimmu.2017.01754. PubMed
  145. Kunimoto H, et al. 2018. Cancer Cell. 33:44. PubMed
  146. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  147. Zhang S, et al. 2019. Mol Med Rep. 19:5377. PubMed
  148. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  149. Riffelmacher T et al. 2017. Immunity. 47(3):466-480 . PubMed
  150. Zheng Y, et al. 2022. Front Pharmacol. 12:816032. PubMed
  151. Dane EL, et al. 2022. Nat Mater. 21:710. PubMed
  152. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  153. Zhang X, et al. 2022. Cells. 11:. PubMed
  154. Donley DW, et al. 2021. PLOS ONE. 16(5):e0250606. PubMed
  155. Jassinskaja M, et al. 2021. Cell Reports. 34(12):108894. PubMed
  156. Ratitong B, et al. 2021. Cell Reports. 35(7):109139. PubMed
  157. Cheng K, et al. 2021. Nat Commun. 12:2041. PubMed
  158. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  159. Pang D, et al. 2015. Clin Transl Immunology. 4: e41. PubMed
  160. Bertino P, et al. 2019. Oncoimmunology. 8:1601482. PubMed
  161. Keshavarz M, et al. 2020. Virol J. 17:64. PubMed
  162. He L, et al. 2019. iScience. 0.790972222. PubMed
  163. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  164. Deng Z, et al. 2017. Oncogene. 36:639. PubMed
  165. Liu D et al. 2019. Immunity. 51(1):64-76 . PubMed
  166. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  167. Kotaki R, et al. 2020. Sci Rep. 10:13554. PubMed
  168. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  169. Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
  170. Jin R, et al. 2020. Mol Cancer Ther. . PubMed
  171. Nguyen TKT, et al. 2020. Am J Pathol. 286:190. PubMed
  172. Jaworska K, et al. 2015. J Immunol. 194:325. PubMed
  173. Chen Y, et al. 2015. PLoS One. 10: 0135217. PubMed
  174. Li L, et al. 2015. J Am Soc Nephrol. 26: 2183-2197. PubMed
  175. Hou M, et al. 2020. Stem Cell Res Ther. 11:55. PubMed
  176. Hönes J, et al. 2017. Sci Rep. . 10.1038/s41598-017-15866-9. PubMed
  177. Niemann J, et al. 2019. Nat Commun. 10:3236. PubMed
  178. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  179. Malekghasemi S, et al. 2020. Cell Biol Int. 44:2031. PubMed
  180. Souza COS, et al. 2021. iScience. 24(6):102548. PubMed
  181. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  182. Hildebrand KM, et al. 2021. PLoS One. 16:e0253864. PubMed
  183. Koshida R, et al. 2015. Biochem Biophys Res Commun. 463: 109-115. PubMed
  184. Textor A, et al. 2014. Cancer Res. 74:6769. PubMed
  185. Frodermann V, et al. 2019. Nat Med. 25:1761. PubMed
  186. Luong-Gardiol N, et al. 2019. Cancer Cell. 35:649. PubMed
  187. Murray C, et al. 2018. Lab Chip. 18:2396. PubMed
  188. Zhao X, et al. 2022. Nat Protoc. 17:2240. PubMed
  189. Baik JE, et al. 2022. Clin Transl Med. 12:e758. PubMed
  190. Di Martino L, et al. 2021. Cell Mol Gastroenterol Hepatol. 13:901. PubMed
  191. Zhang C, et al. 2022. Nat Commun. 13:3468. PubMed
  192. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  193. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  194. Han D, et al. 2021. J Immunol Res. 6688053:2021. PubMed
  195. Nguyen GT, et al. 2021. iScience. 24(8):102871. PubMed
  196. Garg M, et al. 2021. Cell Reports. 34(6):108736. PubMed
  197. Cao DY, et al. 2020. J Biol Chem. 295:1369. PubMed
  198. Moorlag SJCFM, et al. 2020. Cell Rep. 33:108387. PubMed
  199. Kan X, et al. 2015. Cardiovasc Res. 10.1093/cvr/cvv255. PubMed
  200. Zhang H, et al. 2019. Mol Cell. 76:110. PubMed
  201. Liang J, et al. 2020. Sci Adv. 6:eabc3646. PubMed
  202. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  203. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  204. He J, et al. 2019. J Clin Invest. 130. PubMed
  205. Huang Y, et al. 2019. Cancer Cell. 35:677. PubMed
  206. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  207. Colombo M, et al. 2022. iScience. 25:105042. PubMed
  208. Jorapur A, et al. 2022. PLoS Pathog. 18:e1010200. PubMed
  209. Yang Y, et al. 2022. Elife. 11:. PubMed
  210. Bolkhovitina EL, et al. 2022. Int J Mol Sci. 23: . PubMed
  211. Mizuno T, et al. 2017. Sci Rep. 7:42714. PubMed
  212. Holokai L, et al. 2020. Cancers (Basel). 12:00. PubMed
  213. Haas MS, et al. 2020. Mol Cancer Res. 19:717. PubMed
  214. Wang L, et al. 2012. PLoS One. 7:e40056. PubMed
  215. Staschke K, et al. 2009. J Immunol. 183:568. PubMed
  216. Challa TD, et al. 2020. Cell Reports. 30(10):3424-3433. PubMed
  217. Minuesa G, et al. 2019. Nat Commun. 10:2691. PubMed
  218. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  219. Kubota S, et al. 2019. Nat Commun. 10:1653. PubMed
  220. Wang Q, et al. 2018. Int J Biol Sci. 14:147. PubMed
  221. Perez-Garcia CG, et al. 2022. Mol Ther Nucleic Acids. 28:87. PubMed
  222. Uslu M, et al. 2020. J Cell Physiol. 235:9644. PubMed
  223. Zhai K, et al. 2021. Nat Cancer. 2:1136. PubMed
  224. Chiang HY, et al. 2022. Nat Commun. 13:874. PubMed
  225. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  226. Bermejo-Jambrina M, et al. 2021. EMBO J. 40:e106765. PubMed
  227. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  228. Koikawa K, et al. 2021. Cell. 184:4753. PubMed
  229. Sokol L, et al. 2021. STAR Protocols. 2(2):100489. PubMed
  230. Yamakawa D, et al. 2021. Cell Reports. 34(10):108817. PubMed
  231. Troutman TD, et al. 2021. STAR Protocols. 2(1):100363. PubMed
  232. Langhauser F, et al. 2014. Stroke. 45:1799. PubMed
  233. Garcia-Bonilla L, et al. 2014. J Immunol. 193:2531. PubMed
  234. Tao Z, et al. 2019. Clin Cancer Res. 25:1113. PubMed
  235. Tan S, et al. 2006. J Immunol. 176:2872. PubMed
  236. Hsu Y, et al. 2017. Biochem Biophys Res Commun.. 10.1016/j.bbrc.2017.10.067. PubMed
  237. Subramanian K, et al. 2019. Nat Microbiol. 4:62. PubMed
  238. Yang BH, et al. 2020. Cell Reports. 27(12):3629-3645.e6.. PubMed
  239. Gomez–Ospina N, et al. 2019. Nat Commun. 3.225694444. PubMed
  240. Roy AG, et al. 2021. Int J Mol Sci. 22:. PubMed
  241. Liu S, et al. 2022. J Neuroinflammation. 19:35. PubMed
  242. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  243. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  244. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  245. Babagana M, et al. 2021. Aging (Albany NY). 13:19207. PubMed
  246. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  247. Dungan CM, et al. 2022. Aging Cell. 21:e13528. PubMed
  248. Favuzzi E, et al. 2021. Cell. 184(15):4048-4063.e32. PubMed
  249. Li L, et al. 2014. J Immunol. 192:1034. PubMed
  250. Demers M, et al. 2012. Proc Natl Acad Sci U S A. 109:13076. PubMed
  251. Gladow N, et al. 2020. PLoS One. 15:e0227734. PubMed
  252. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  253. Li YT, et al. 2019. Elife. 8:e47642. PubMed
  254. Luck H, et al. 2019. Nat Commun. 10:3650. PubMed
  255. Xiao G, et al. 2018. Cell. 173:470. PubMed
  256. Spangenberg E, et al. 2019. Nat Commun. 10:3758. PubMed
  257. Wu ZJ, et al. 2018. Int J Oncol. 52:1209. PubMed
  258. Szeifert V, et al. 2021. Front Immunol. 12:671995. PubMed
  259. Saber M, et al. 2021. J Neurosci Res. 99:1136. PubMed
  260. Wang W, et al. 2021. J Am Heart Assoc. 10:e019142. PubMed
  261. Berghoff SA, et al. 2021. Nat Neurosci. 24:47. PubMed
  262. Cao W, et al. 2021. Int J Mol Sci. 22:. PubMed
  263. Calle P, et al. 2021. Cells. 10:. PubMed
  264. Li T, et al. 2021. J Neuroinflammation. 81:18. PubMed
  265. Guo M, et al. 2020. Brain. 1476:143. PubMed
  266. Houben T, et al. 2020. J Pathol. 251:429. PubMed
  267. Cai Z, et al. 2020. Cell Rep. 31:107816. PubMed
  268. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  269. Cá B, et al. 2019. Front Microbiol. 1.876388889. PubMed
  270. Bennett FC, et al. 2018. Neuron. 98:1170. PubMed
  271. Zhang T, et al. 2018. PLoS One. 13:e0196571. PubMed
  272. Eisemann T, et al. 2019. Front Oncol. 9:187. PubMed
  273. Tomimatsu M, et al. 2022. Sci Rep. 12:16656. PubMed
  274. Yuan Y, et al. 2020. Front Physiol. 0.967361111. PubMed
  275. Varikuti S, et al. 2020. Br J Cancer. 122:1005. PubMed
  276. Toyohara T, et al. 2020. Cell Stem Cell. 27:147. PubMed
  277. Dong Y, et al. 2021. Commun Biol. 4:560. PubMed
  278. Scheiblich H, et al. 2021. Cell. 184:5089. PubMed
  279. Jablonski K, et al. 2015. PLoS One. 10: 0145342. PubMed
  280. Sanders K, et al. 2015. Cancer Immunol Res. 3: 891-901. PubMed
  281. Yuan C, et al. 2015. Biochem Biophys Res Commun. 464: 249-255. PubMed
  282. Resende M, et al. 2013. J Immunol. 191:262. PubMed
  283. Muri J, et al. 2020. Cell Reports. 29(9):2731-2744.e4.. PubMed
  284. Liu Y, et al. 2019. Sci Rep. 9:18970. PubMed
  285. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  286. Gerdes P, et al. 2022. Nat Commun. 13:7470. PubMed
  287. Düking T, et al. 2022. Sci Adv. 8:eabo7639. PubMed
  288. Wang X, et al. 2021. Cell. 184:5357. PubMed
  289. Li Y, et al. 2020. Theranostics. 10:2897. PubMed
  290. Xia D, et al. 2022. Mol Neurodegener. 17:41. PubMed
  291. Koide S, et al. 2022. iScience. 25:103603. PubMed
  292. Lin T, et al. 2021. PLoS Pathog. 17:e1009557. PubMed
  293. Casselli T, et al. 2021. PLoS Pathog. 17:e1009256. PubMed
  294. Yokomizo-Nakano T, et al. 2020. Cancer Res. 80:2523. PubMed
  295. Lin KH, et al. 2020. Nat Genet. 52:408. PubMed
  296. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  297. Schaftenaar FH, et al. 2019. Sci Rep. 9:17391. PubMed
  298. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  299. Nguyen GT, et al. 2020. eLife. 9:e56656.. PubMed
  300. Hoyer FF, et al. 2020. Immunity. 51(5):899-914.e7.. PubMed
  301. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  302. Yang N, et al. 2022. Nat Commun. 13:2336. PubMed
  303. Zhai T, et al. 2020. Clin Exp Pharmacol Physiol. 47:677. PubMed
  304. Li K, et al. 2020. Nat Commun. 4.844444444. PubMed
  305. Avalle L, et al. 2020. Mol Ther Methods Clin Dev. 0.793055556. PubMed
  306. Zhou Q, et al. 2020. Nat Immunol. 1.393055556. PubMed
  307. Rodríguez L, et al. 2021. Biomolecules. 11: . PubMed
  308. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  309. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  310. Garcia-Bonilla L, et al. 2015. J Neurosci. 35: 14783 - 14793. PubMed
  311. Baruch K, et al. 2015. EMBO J. 34: 1816 - 1828. PubMed
  312. Schmidt C, et al. 2005. J Immunol. 175:2286. PubMed
  313. Danne C et al. 2017. Cell host & microbe. 22(6):733-745 . PubMed
  314. Luo H, et al. 2019. Cell Rep. 26:945. PubMed
  315. Bozoglu T, et al. 2022. Adv Sci (Weinh). 9:e2103867. PubMed
  316. Shen H, et al. 2022. Nat Commun. 13:5013. PubMed
  317. Zhang X, et al. 2022. J Exp Clin Cancer Res. 41:246. PubMed
  318. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  319. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  320. Bahmani B, et al. 2021. Nat Commun. 12:1999. PubMed
  321. Fielding C, et al. 2022. Nat Commun. 13:543. PubMed
  322. Saber M, et al. 2020. Eur J Neurosci. 52:2791. PubMed
  323. Hirako N, et al. 2014. PLoS One. 9:103282. PubMed
  324. Chen Z, et al. 2016. Innate Immunity. 22: 419 - 432. PubMed
  325. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  326. Zhang M, et al. 2019. Autophagy. 1.423611111. PubMed
  327. Wunderlich CM, et al. 2018. Nat Commun. 9:1646. PubMed
  328. Arima Y et al. 2017. eLife. 6 pii: e25517. PubMed
  329. Wang T, et al. 2022. Int J Nanomedicine. 17:2191. PubMed
  330. Gawish R, et al. 2022. Elife. 11:. PubMed
  331. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  332. Evavold CL, et al. 2021. Cell. 184(17):4495-4511.e19. PubMed
  333. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  334. Wang K, et al. 2021. Nat Commun. 12:4558. PubMed
  335. Henkle TR, et al. 2021. Cancer Res. 81:4560. PubMed
  336. K K, et al. 2016. Haematologica. 151159. PubMed
  337. Han J, et al. 2015. Cancer Res . 75: 5273 - 5282. PubMed
  338. Cai W, et al. 2019. J Neuroinflammation. 0.788194444. PubMed
  339. Fernando N, et al. 2020. Front Cell Dev Biol. 0.691666667. PubMed
  340. Dougan M, et al. 2018. Cancer Immunol Res. 6:389. PubMed
  341. Abdel Malik R, et al. 2017. Circ Res. 120:99. PubMed
  342. Saber M, et al. 2021. J Neurotrauma. 38:2862. PubMed
  343. Sethuraman SN, et al. 2020. Theranostics. 10:3397. PubMed
  344. Zhang SJ, et al. 2021. Adv Sci (Weinh). 8:2003410. PubMed
  345. Steinmetz TD, et al. 2021. Autophagy. 17:2238. PubMed
  346. Hohsfield LA, et al. 2021. Elife. 10:. PubMed
  347. Kaya-Tilki E, et al. 2021. PLoS One. 16:e0260633. PubMed
  348. Zhang J, et al. 2021. Stem Cell Res Ther. 12:579. PubMed
  349. Amend A, et al. 2021. Int J Mol Sci. 22:. PubMed
  350. Rana MN, et al. 2021. Front Pharmacol. 12:643215. PubMed
  351. Nabekura T, et al. 2020. Immunity. 96:52. PubMed
  352. Wong PP, et al. 2020. Cell. 181(6):1346-1363.e21. PubMed
  353. Guo S, et al. 2021. Frontiers in Immunology. 11:614667. PubMed
  354. Scharenberg SG, et al. 2020. Nat Commun. 2.76875. PubMed
RRID
AB_312790 (BioLegend Cat. No. 101207)
AB_312791 (BioLegend Cat. No. 101208)

Antigen Details

Structure
Integrin family, associates with integrin β2 (CD18), 170 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, NK cells, subsets of T and B cells

Function
Adhesion, chemotaxis
Ligand/Receptor
ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, fibrinogen
Cell Type
B cells, Dendritic cells, Granulocytes, Macrophages, Monocytes, Neutrophils, NK cells, T cells, Tregs
Biology Area
Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.
2. Springer TA. 1994. Cell 76:301.
3. Coxon A, et al. 1996. Immunity 5:653.

Gene ID
16409 View all products for this Gene ID 3684 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD11b
Specificity Alt (DOES NOT SHOW ON TDS):
CD11b
App Abbreviation (DOES NOT SHOW ON TDS):
FC,IHC
Hidden Names (DOES NOT SHOW ON TDS):
aM integrin, alpha integrin, alphaM integrin, alpha M integrin, integrin alphaM, integrin aM, integrin alpha M, CD11, Macrophage, Myeloid Dendritic Cell, Neutrophil, NK Cell, Plasmacytoid Dendritic Cell, Microglia
UniProt
View information about CD11b on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.

Other Formats

View All CD11b Reagents Request Custom Conjugation
Description Clone Applications
PE/Cyanine7 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 750 anti-mouse/human CD11b M1/70 FC
TotalSeq™-A0014 anti-mouse/human CD11b M1/70 PG
Brilliant Violet 750™ anti-mouse/human CD11b M1/70 FC
TotalSeq™-B0014 anti-mouse/human CD11b M1/70 PG
TotalSeq™-C0014 anti-mouse/human CD11b M1/70 PG
Spark NIR™ 685 anti-mouse/human CD11b M1/70 FC
PE/Fire™ 640 anti-mouse/human CD11b M1/70 FC
APC anti-mouse/human CD11b M1/70 FC
Biotin anti-mouse/human CD11b M1/70 FC
FITC anti-mouse/human CD11b M1/70 FC
PE anti-mouse/human CD11b M1/70 FC,IHC
PE/Cyanine5 anti-mouse/human CD11b M1/70 FC
Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,IHC-F,ICC
Alexa Fluor® 488 anti-mouse/human CD11b M1/70 FC,IHC-F,3D IHC,SB
Alexa Fluor® 647 anti-mouse/human CD11b M1/70 FC,3D IHC,SB
Alexa Fluor® 700 anti-mouse/human CD11b M1/70 FC
Pacific Blue™ anti-mouse/human CD11b M1/70 FC
APC/Cyanine7 anti-mouse/human CD11b M1/70 FC
PerCP/Cyanine5.5 anti-mouse/human CD11b M1/70 FC
PerCP anti-mouse/human CD11b M1/70 FC
Brilliant Violet 421™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 570™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 605™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 650™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 711™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 785™ anti-mouse/human CD11b M1/70 FC
Brilliant Violet 510™ anti-mouse/human CD11b M1/70 FC,ICC
Ultra-LEAF™ Purified anti-mouse/human CD11b M1/70 FC,CyTOF®,IP,Block,Depletion,IHC-F,ICC
Purified anti-mouse/human CD11b (Maxpar® Ready) M1/70 FC,CyTOF®
Alexa Fluor® 594 anti-mouse/human CD11b M1/70 IHC-F,FC
PE/Dazzle™ 594 anti-mouse/human CD11b M1/70 FC
Spark YG™ 593 anti-mouse/human CD11b M1/70 FC
Spark YG™ 570 anti-mouse/human CD11b M1/70 IHC-F
PE/Fire™ 810 anti-mouse/human CD11b M1/70 FC
APC/Fire™ 810 anti-mouse/human CD11b Antibody M1/70 FC
Spark Blue™ 550 anti-mouse/human CD11b M1/70 FC
Spark UV™ 387 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 806 anti-mouse/human CD11b M1/70 FC
PerCP/Fire™ 780 anti-mouse/human CD11b M1/70 FC
Spark Blue™ 574 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
KIRAVIA Blue 520™ anti-mouse/human CD11b M1/70 FC
PE/Fire™ 744 anti-mouse/human CD11b M1/70 FC
Spark PLUS UV395™ anti-mouse/human CD11b M1/70 FC
Spark Red™ 718 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
Spark PLUS B550™ anti-mouse/human CD11b M1/70 FC
Spark YG™ 581 anti-mouse/human CD11b (Flexi-Fluor™) M1/70 FC
StarBright UltraViolet 575 anti-mouse/human CD11b M1/70 FC
StarBright UltraViolet 740 anti-mouse/human CD11b M1/70 FC
Spark PLUS V475™ anti-mouse/human CD11b M1/70 FC
Spark PLUS YG581™ anti-mouse/human CD11b M1/70 FC
Spark PLUS V450™ anti-mouse/human CD11b M1/70 FC
Go To Top Version: 2    Revision Date: 03/14/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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