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NucView® 488 Caspase-3 Substrate

Pricing & Availability
Regulatory Status
RUO
Other Names
Caspase-3 substrate, Caspase 3, Caspase probe
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Product Citations
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421928 100 µL 590 CHF
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Description

Caspase 3 is an effector caspase that plays a major role in the apoptotic pathway and activated by initiator caspase during the early stages of apoptosis. Its activity ultimately leads to apoptotic chromatin condensation and DNA fragmentation.

This substrate is a four-amino acid DEVD peptide conjugated to a high-affinity DNA-binding dye. The non-fluorescent caspase-3 substrate enters the cytoplasm, and active Caspase-3 in apoptotic cells cleaves the substrate, releasing the DNA-binding dye. The DNA dye migrates to the nucleus and fluoresces upon binding to DNA. Thus, this probe allows for detection of caspase 3 activity in live cells by imaging and flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Mouse, Species independent

Antigen Details

Structure
Fluorogenic DNA dye coupled to the caspase DEVD recognition sequence
Function
Detection of caspase activity
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Cell Death
Gene ID
NA
Go To Top Version: 0    Revision Date: 01.01.0001

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

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