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- Clone
- W20150F (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Macrophage inflammatory protein 1-alpha, LD78a
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 168302 | 100 µg | 380 CHF | ||||
CCL3 is a chemokine of the CC chemokine family that is involved in the activation and recruitment of lymphocytes, monocytes, and granulocytes during acute inflammation. In addition to regulating leukocyte migration, CCL3 enhances IFN-γ secretion from activated T cells and thus induces Th1 responses. Moreover, CCL3 has been reported to be involved in susceptibility of HIV infection and disease progression of AIDS. CCL3 expression is also increased during atherosclerotic lesion formation in mice, and CCL3 deficiency inhibits atherosclerotic lesion development by affecting neutrophil accumulation. Previous data has shown that CCL3 uses CCR1 to promote neutrophil recruitment in OVA-challenged, immunized mice.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CCL3 protein (aa 24-92) expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Antigen Details
- Structure
- 7.8 kD, CC chemokine
- Distribution
-
Macrophages, monocytes, B cells, T cells, NK cells, granulocytes, platelets, dendritic cells
- Function
- CCL3 chemokine is a chemoattractant that recruits and activates leukocytes to sites of infection or inflammation.
- Interaction
- Macrophages, CD8+ lymphocytes, B cells, granulocytes, dendritic cells
- Ligand/Receptor
- CCR1, CCR4, CCR5, CCR9
- Cell Type
- Dendritic cells, Granulocytes, Macrophages, Monocytes, NK cells, Platelets, T cells
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
-
- Menten P, et al. 2002. Cytokine Growth Factor Rev. 13:455.
- Blum S, et al. 1990. DNA Cell. Biol. 9:589.
- Czaplewski LG, et al. 1999. J. Biol. Chem. 274:16077.
- Paximadis M, et al. 2009. Int. J. Immunogenet. 36:21.
- Cocchi F, et al. 1995. Science. 270:1811.
- Meddows-Taylor S, et al. 2006. J. Gen. Virol. 87:2055.
- de Jager SC, et al. 2013. Arterioscler. Thromb. Vasc. Biol. 33:e75.
- Ramos CD, et al. 2005. J. Leuko. Biol. 78:167.
- Gene ID
- 20302 View all products for this Gene ID
- UniProt
- View information about CCL3 on UniProt.org
Related FAQs
Other Formats
View All CCL3 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CCL3 (MIP-1α) | W20150F | ICFC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CCL3 (MIP-1α)
LPS- stimulated (in the presence of monensin, 6 hours) RAW26...
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