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APC anti-mouse F4/80 Antibody

Pricing & Availability
Clone
BM8 (See other available formats)
Regulatory Status
RUO
Other Names
EMR1, Ly71
Isotype
Rat IgG2a, κ
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Product Citations
publications
BM8_APC_122007
Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
  • BM8_APC_122007
    Thioglycolate-elicited BALB/c mouse peritoneal macrophages stained with BM8 APC
Compare all formats See APC spectral data
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123115 25 µg 40€
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123116 100 µg 115€
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Description

F4/80, also known as EMR1 or Ly71, is a 160 kD glycoprotein of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80 has been widely used as a murine macrophage marker. It is expressed on a majority of tissue macrophages, including macrophages in the lung, gut, peritoneal cavity, thymus, and red pulp of the spleen, Kupffer cells, Langerhans cells, microglia, and certain dendritic cells. It is not expressed on macrophages located in the T cell areas of the spleen, lymph node, or Peyer's patch. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for the induction of CD8+ T cells-mediated peripheral tolerance.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Murine macrophages
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The F4/80 antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections1,2 and formalin-fixed paraffin-embedded sections6,7, Western blotting, and spatial biology (IBEX)12,13.

Application References

(PubMed link indicates BioLegend citation)
  1. Schaller E, et al. 2002. Mol. Cell. Biol. 22:8035. (IHC)
  2. Stevceva L, et al. 2001. BMC Clin Pathol. 1:3. (IHC)
  3. Kobayashi M, et al.2008. J. Leukoc. Biol. 83:1354. PubMed
  4. Poeckel D, et al. 2009. J. Biol Chem. 284:21077. PubMed
  5. Glass AM, et al. 2013. J. Immunol. 190:4830. PubMed
  6. Koehm S, et al. 2007. J. Allergy Clin. Immunol. 120:570. (IHC)
  7. Rankin AL, et al. 2010. J. Immunol. 184:1526. (IHC)
  8. Sasi SP, et al. 2014. J Biol Chem. 289:14178. PubMed
  9. Thakus VS, et al. 2014. Toxicol Lett. 230:322. PubMed
  10. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
  11. Hirakawa H, et al. 2015. PLoS One. 10:119360. PubMed
  12. Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed
  13. Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed
Product Citations
  1. Huang W, et al. 2015. J Allergy Clin Immunol. . PubMed
  2. Barrett N, et al. 2016. Cell Rep. 16: 1039-1054. PubMed
  3. Ying W, et al. 2019. Cell Metab. 29:457. PubMed
  4. Saha D et al. 2017. Cancer cell. 32(2):253-267 . PubMed
  5. Nesseler JP, et al. 2020. Cancers (Basel). 12: . PubMed
  6. Tian WJ, et al. 2021. Clin Exp Pharmacol Physiol. 48:902. PubMed
  7. Fang C, et al. 2022. J Pathol. 256:310. PubMed
  8. Ozga AJ, et al. 2022. Immunity. 55:82. PubMed
  9. Liang X, et al. 2022. Cancer Commun (Lond). 42:205. PubMed
  10. Yousefi M, et al. 2022. Cancer Res. 82:1589. PubMed
  11. Chen J, et al. 2022. Adv Sci (Weinh). 9:e2200668. PubMed
  12. Sipilä K, et al. 2022. Dev Cell. 57:1453. PubMed
  13. Jang HJ, et al. 2022. Cancer Res. 82:2593. PubMed
  14. Aghayev T, et al. 2022. Cancer Discov. 12:1960. PubMed
  15. Xu J, et al. 2022. Invest Ophthalmol Vis Sci. 63:15. PubMed
  16. Schaue D, et al. 2022. Antioxidants (Basel). 11: . PubMed
  17. Roy IM, et al. 2022. iScience. 25:105171. PubMed
  18. Gong F, et al. 2023. Adv Healthc Mater. 12:e2201771. PubMed
  19. Yoo HJ, et al. 2022. Cell Rep. 41:111598. PubMed
  20. Nagre N, et al. 2022. Respir Res. 23:326. PubMed
  21. Miao Y, et al. 2022. Front Pharmacol. 13:1032741. PubMed
  22. Kuo CS, et al. 2022. Elife. 11: . PubMed
  23. Lee DE, et al. 2022. Nat Commun. 13:7613. PubMed
  24. Wang R, et al. 2023. Nat Biomed Eng. 7:38. PubMed
  25. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  26. Fan R, et al. 2023. J Immunother Cancer. 11: . PubMed
  27. Wang Y, et al. 2023. FASEB J. 37:e22776. PubMed
  28. Fontana MF, et al. 2023. Elife. 12: . PubMed
  29. Kulkarni R, et al. 2023. Life Sci Alliance. 6: . PubMed
  30. Slusarczyk P, et al. 2023. Elife. 12: . PubMed
  31. He Y, et al. 2023. Nat Commun. 14:691. PubMed
  32. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  33. Li S, et al. 2023. Exp Mol Med. 55:457. PubMed
  34. Li FJ, et al. 2022. Am J Physiol Lung Cell Mol Physiol. 322:L593. PubMed
  35. Kraynak CA, et al. 2022. Int J Pharm. 618:121634. PubMed
  36. Fernández-García V, et al. 2022. Biomed Pharmacother. 148:112769. PubMed
  37. Mise Y, et al. 2022. Carcinogenesis. 43:647. PubMed
  38. Quattrocelli M, et al. 2022. J Exp Med. 219:. PubMed
  39. Hailemichael Y, et al. 2022. Cancer Cell. 40:509. PubMed
  40. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  41. Lin J, et al. 2022. Adv Sci (Weinh). 9:e2202633. PubMed
  42. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  43. Czimmerer Z, et al. 2022. Immunity. 55:2006. PubMed
  44. Amodio V, et al. 2023. Cancer Cell. 41:196. PubMed
  45. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  46. Pan Y, et al. 2023. Adv Sci (Weinh). 10:e2206792. PubMed
  47. Liu PS, et al. 2023. Nat Immunol. 24:452. PubMed
  48. Mizutani T, et al. 2023. iScience. 26:106081. PubMed
  49. Liu N, et al. 2023. Cell Death Dis. 14:170. PubMed
  50. Spitzer D, et al. 2023. Nat Protoc. 18:1510. PubMed
  51. Wang Y, et al. 2023. EBioMedicine. 90:104480. PubMed
  52. Tan J, et al. 2023. Acta Pharm Sin B. 13:632. PubMed
  53. Adzika GK, et al. 2023. Front Immunol. 14:1124649. PubMed
  54. Zhu S, et al. 2023. J Nanobiotechnology. 21:81. PubMed
  55. Do-Thi VA, et al. 2023. Cancer Res Commun. 3:80. PubMed
  56. He XY, et al. 2023. Nat Commun. 14:2253. PubMed
  57. Okano F, et al. 2023. Cancer Res Commun. 3:640. PubMed
  58. He Q, et al. 2023. Parasit Vectors. 16:139. PubMed
  59. Li T, et al. 2023. Nat Commun. 14:2498. PubMed
  60. Shen Z, et al. 2023. iScience. 26:106572. PubMed
  61. Ji Y, et al. 2023. Nat Cell Biol. 25:726. PubMed
  62. He Y, et al. 2023. Biomolecules. 13:. PubMed
  63. Wang C, et al. 2023. Int J Oral Sci. 15:19. PubMed
  64. Wang K, et al. 2023. Nat Commun. 14:2950. PubMed
  65. Song S, et al. 2023. Bioact Mater. 28:358. PubMed
  66. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  67. Nguyen T, et al. 2021. STAR Protoc. 2:101004. PubMed
  68. Rosina M, et al. 2022. Cell Metab. 34:533. PubMed
  69. Grandjean CL, et al. 2021. Sci Adv. 7:. PubMed
  70. Deng R, et al. 2022. Adv Sci (Weinh). 9:e2103343. PubMed
  71. Yang D, et al. 2022. Cell. 185:1905. PubMed
  72. Zheng J, et al. 2022. Front Pharmacol. 13:866228. PubMed
  73. Furrer R, et al. 2021. Sci Adv. 7:eabi4852. PubMed
  74. Li Z, et al. 2022. Nat Commun. 13:1845. PubMed
  75. Liu Y, et al. 2021. Cell Metabolism. 33(6):1221-1233.e11. PubMed
  76. Zhao Z, et al. 2021. Nat Commun. 12:4355. PubMed
  77. Du, J., Fan, Y., et al. 2025. Oncoimmunology. 14(1),2590245. PubMed
  78. Sharma-Chawla N, et al. 2016. Infect Immun . . PubMed
  79. Emal D, et al. 2016. J Am Soc Nephrol. 10.1681/ASN.2016030255. PubMed
  80. Dale M, et al. 2016. J Immunol. 196: 4536 - 4543. PubMed
  81. Kawano H, et al. 2016. Int Immunol. 28: 489 - 501. PubMed
  82. Jaiswal M, et al. 2015. Sci Rep. 5: 15221. PubMed
  83. Bieren J, et al. 2015. J Immunol. 194:1154. PubMed
  84. Prantner D, et al. 2009. Infect Immun. 77:5334. PubMed
  85. Cullis J, et al. 2017. Cancer Immunol Res. 5:182. PubMed
  86. Kim SE, et al. 2019. Nutrients. 11. PubMed
  87. Chang T, et al. 2017. PLoS Pathog. 10.1371/journal.ppat.1006485. PubMed
  88. Yan X, et al. 2022. Commun Biol. 5:320. PubMed
  89. Li Y, et al. 2022. Int J Biol Sci. 18:3697. PubMed
  90. He R, et al. 2021. J Immunol. 206:2353. PubMed
  91. Suresh R, et al. 2020. J Immunother Cancer. 8:. PubMed
  92. Symeonidou V, et al. 2021. Cell Rep. 37:109900. PubMed
  93. Zhang R, et al. 2021. Cell Mol Immunol. 18:1222. PubMed
  94. Kurosawa M, et al. 2021. Int J Mol Sci. 22:. PubMed
  95. He F, et al. 2021. J Exp Med. 218:. PubMed
  96. Platt DJ, et al. 2021. Cell Reports. 35(6):109113. PubMed
  97. Du J, et al. 2020. Developmental Cell. 55(6):737-753.e7. PubMed
  98. Gerwing M, et al. 2020. Mol Imaging Biol. 1.959027778. PubMed
  99. Bousset L, et al. 2020. PLoS Biol. 18:e3000948. PubMed
  100. Yu J, et al. 2020. Sci Rep. 10:21360. PubMed
  101. Sjöstrand M, et al. 2013. J Immunol. 191:3753. PubMed
  102. Li X, et al. 2015. Proc Natl Acad Sci U S A. 112:6080. PubMed
  103. Tan X, et al. 2016. PLoS One. 11: 0160985. PubMed
  104. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  105. Lee H, et al. 2020. Cell Metabolism. 31(4):822-836. PubMed
  106. Stubelius A, et al. 2012. Immunobiology. 217:751. PubMed
  107. Gonçalves NP, et al. 2017. J Neuroinflammation. 14:115. PubMed
  108. Yates C, et al. 2017. Stem Cell Res Ther. 10.1186/s13287-017-0644-9. PubMed
  109. Lancaster JN, et al. 2019. Nat Commun. 10:2220. PubMed
  110. Sepe JJ, et al. 2022. JACC Basic Transl Sci. 7:915. PubMed
  111. Jiang W, et al. 2021. Oncol Lett. 22:625. PubMed
  112. Liang S, et al. 2022. Acta Pharm Sin B. 12:2494. PubMed
  113. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  114. Dong L, et al. 2021. Cancer Cell. . PubMed
  115. Xing J, et al. 2016. Nat Immunol. 17:1373-1380. PubMed
  116. Zhu J, et al. 2016. Sci Rep. 6:27136. PubMed
  117. Sun P, et al. 2015. J Hepatol. . PubMed
  118. Shen H, et al. 2015. Infect Immun . 83: 2694 - 2704. PubMed
  119. Gritsina G, et al. 2015. Mol Cancer Ther. 14:1035. PubMed
  120. Wong E, et al. 2019. Cell Rep. 29:3047. PubMed
  121. Wu R, et al. 2019. J Cell Mol Med. 24:1684. PubMed
  122. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  123. Neumann AM et al. 2017. PloS one. 12(11):e0187330 . PubMed
  124. Han J, et al. 2022. FEBS J. 289:417. PubMed
  125. Zhao J, et al. 2022. J Nanobiotechnology. 20:62. PubMed
  126. Liang F, et al. 2021. Front Immunol. 12:658715. PubMed
  127. Nam J, et al. 2021. Adv Sci (Weinh). 2002577:8. PubMed
  128. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  129. Zheng H, et al. 2021. Frontiers in Cell and Developmental Biology. 9:641527. PubMed
  130. Xu Y, et al. 2020. Mol Ther. 28:202. PubMed
  131. Mia MM, et al. 2020. PLoS Biol. 18:e3000941. PubMed
  132. Rybalko V, et al. 2015. PLoS One. 10: 0145550. PubMed
  133. Ohtsuki T, et al. 2016. J Virol. 90: 300 - 307. PubMed
  134. Zhong J, et al. 2018. Sci Adv. 4:eaas9864. PubMed
  135. Qi F, et al. 2017. Molecular Immunology. 10.1016/j.molimm.2017.05.008. PubMed
  136. Stefan K, et al. 2017. PLoS One. . 10.1371/journal.pone.0188600. PubMed
  137. Sinha M, et al. 2018. Nat Commun. 9:936. PubMed
  138. Grohmann M et al. 2018. Cell. 175(5):1289-1306 . PubMed
  139. Kosack L, et al. 2017. Sci Rep. 7:11289. PubMed
  140. Christopher S Garris et al. 2018. Immunity. 49(6):1148-1161 . PubMed
  141. Duarte N, et al. 2018. Hepatol Commun. 0.833333333. PubMed
  142. Sun Q, et al. 2022. Cell Death Dis. 13:724. PubMed
  143. Tajfirouz D, et al. 2017. Virology. 10.1016/j.virol.2017.02.022. PubMed
  144. Krivanek J, et al. 2020. Nat Commun. 3.802777778. PubMed
  145. Brestoff JR, et al. 2021. Cell Metab. 33:270. PubMed
  146. Evren E, et al. 2020. Immunity. 54(2):259-275.e7. PubMed
  147. Esmaili S, et al. 2021. Cell Systems. 12(5):432-445.e7. PubMed
  148. Jeong D, et al. 2021. eLife. 0.416666666666667. PubMed
  149. Molina-Sanchez P, et al. 2020. Gastroenterology. 2203:159. PubMed
  150. Shang Y, et al. 2016. Nat Immunol. 10.1038/ni.3486. PubMed
  151. Lasky C, et al. 2015. Infect Immun . 83: 2627 - 2635. PubMed
  152. Peng L, et al. 2020. Transl Lung Cancer Res. 0.892361111. PubMed
  153. Vannini N, et al. 2019. Cell Stem Cell. 24:405. PubMed
  154. Nguyen CM, et al. 2019. Diabetes. 68:1499. PubMed
  155. Dey A et al. 2019. The EMBO journal. 38(7) pii: e100293. PubMed
  156. Cao W, et al. 2017. Immunity. 47:1182. PubMed
  157. Wang Y, et al. 2022. Front Immunol. 13:767630. PubMed
  158. Hou H, et al. 2021. Front Cell Dev Biol. 9:737003. PubMed
  159. Kosaric N, et al. 2020. Mol Ther. 28:2007. PubMed
  160. Ling X, et al. 2021. ACS Nano. 15:765. PubMed
  161. Gordon RA, et al. 2020. PLoS One. 15:e0226396. PubMed
  162. He C, et al. 2021. Oncoimmunology. 1897295:10. PubMed
  163. Jiao H, et al. 2021. Cell. 184(11):2896-2910.e13. PubMed
  164. Helmi N, et al. 2015. J Infect Dis. 211:1677. PubMed
  165. Tsoyi K, et al. 2015. J Leukoc Biol. 97:171. PubMed
  166. Ma Y, et al. 2015. Cardiovasc Res. 106:421. PubMed
  167. Ben-Shaanan T, et al. 2016. Nat Med. 10.1038/nm.4133. PubMed
  168. Giri J, et al. 2020. Cell Rep. 30:1923. PubMed
  169. Galvão I, et al. 2018. Front Immunol. 9:142. PubMed
  170. Alexander RK, et al. 2020. eLife. 9:e54090.. PubMed
  171. Prantner D, et al. 2011. Infect Immun. 79:3922. PubMed
  172. Parada-Kusz M, et al. 2018. Dis Model Mech. 11:. PubMed
  173. Luan HH et al. 2019. Cell. 178(5):1231-1244 . PubMed
  174. Shimokawa C et al. 2017. Immunity. 46(5):863-874 . PubMed
  175. Rao X, et al. 2022. Cell Death Dis. 13:891. PubMed
  176. Jeong SJ, et al. 2021. Autophagy. 17:3740. PubMed
  177. Guo W, et al. 2022. J Immunother Cancer. 10:. PubMed
  178. Shin JE, et al. 2021. Heliyon. 7:e08433. PubMed
  179. Karki R, et al. 2020. JCI Insight. 5:00. PubMed
  180. Chi Z, et al. 2020. Molecular Cell. 80(1):43-58.e7. PubMed
  181. Sun L, et al. 2020. J Immunol. 2177:204. PubMed
  182. Müller A, et al. 2020. J Clin Invest. 5765:130. PubMed
  183. Agrawal V, et al. 2016. J Leukoc Biol. 100: 261 - 274. PubMed
  184. Amash A, et al. 2016. J Immunol. 196: 3331-3340. PubMed
  185. Gereke M, et al. 2012. J Vis Exp. 70: 4322. PubMed
  186. Sullivan B, et al. 2015. PLoS Pathog. 11:1004588. PubMed
  187. Oatley J, et al. 2009. Development. 136:1191. PubMed
  188. Frazier T, et al. 2018. Adipocyte. 0.41875. PubMed
  189. An W et al. 2019. British journal of pharmacology. 176(5):699-710 . PubMed
  190. Yu Y, et al. 2019. J Clin Invest. 129:546. PubMed
  191. Linde N, et al. 2018. Nat Commun. 9:21. PubMed
  192. Anstine L,et al. 2017. J Am Heart Assoc.. 10.1161/JAHA.117.007097. PubMed
  193. Zein HS, et al. 2022. Sci Rep. 12:4834. PubMed
  194. Luo W, et al. 2022. Front Immunol. 13:816761. PubMed
  195. Lv F, et al. 2022. iScience. 25:103639. PubMed
  196. Wu L, et al. 2022. Theranostics. 12:842. PubMed
  197. Stump CT, et al. 2021. Open Biol. 11:210245. PubMed
  198. Jiao Y, et al. 2021. Crit Care. 25:356. PubMed
  199. Gao H, et al. 2021. Cells. 10:. PubMed
  200. Carozza JA, et al. 2020. Nat Cancer. 184:1. PubMed
  201. Glauser D, et al. 2013. J Virol. 87:10828. PubMed
  202. Bretscher P, et al. 2015. EMBO Mol Med. 7:593. PubMed
  203. Hara-Chikuma H 2016. Mol Cell Biol. 36: 1206-1218. PubMed
  204. Liao T, et al. 2017. Front Immunol. 8:1334. PubMed
  205. Deng M, et al. 2020. Nat Commun. 11:2193. PubMed
  206. Chen F et al. 2018. Cell reports. 25(10):2775-2783 . PubMed
  207. Shi R, et al. 2022. Theranostics. 12:875. PubMed
  208. Du Y, et al. 2022. Nat Commun. 13:231. PubMed
  209. Hu J, et al. 2020. Theranostics. 7.154166667. PubMed
  210. DeVito NC, et al. 2021. Cell Reports. 35(5):109071. PubMed
  211. Gozgit JM, et al. 2021. Cancer Cell. :. PubMed
  212. Mao FY, et al. 2021. Cell Mol Gastroenterol Hepatol. 12:395. PubMed
  213. Cheng Y, et al. 2020. PLoS Pathog. 16:e1008569. PubMed
  214. Wang W, et al. 2018. Oncogenesis. 7:97. PubMed
  215. Xie Z, et al. 2018. J Am Heart Assoc. 7:e007442. PubMed
  216. Pinho S, et al. 2022. Nat Cell Biol. 24:290. PubMed
  217. Lin S, et al. 2022. Nat Commun. 13:3301. PubMed
  218. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  219. Ye P, et al. 2022. Front Cardiovasc Med. 8:810477. PubMed
  220. Zhang Y, et al. 2021. J Immunol Res. 2021:5599439. PubMed
  221. Tartey S, et al. 2021. Cancer Research. 81(9):2358-2372. PubMed
  222. Fairfax K, et al. 2013. J Immunol. 191:4202. PubMed
  223. Ericson J, et al. 2014. PLoS One. 9:108553. PubMed
  224. Li Y, et al. 2020. Cell Reports. 27(10):2809-2816.e3.. PubMed
  225. Wang T, et al. 2018. Front Physiol. 9:209. PubMed
  226. Xiang W, et al. 2018. Nat Commun. 9:2574. PubMed
  227. Moon HG et al. 2018. Immunity. 49(2):275-287 . PubMed
  228. LaFleur MW, et al. 2019. Nat Commun. 10:1668. PubMed
  229. Hu J, et al. 2019. Mol Ther Nucleic Acids. 16:650. PubMed
  230. Matundan H, et al. 2019. J Virol. 93. PubMed
  231. Yu L, et al. 2019. Elife. 8:e46677. PubMed
  232. Ruiz de Azua I, et al. 2017. J Clin Invest. 127:4148. PubMed
  233. Yang Y, et al. 2022. Elife. 11:. PubMed
  234. Toda G, et al. 2021. STAR Protoc. 2:100246. PubMed
  235. Guldner IH, et al. 2020. Cell. 183(5):1234-1248.e25. PubMed
  236. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  237. Fraccarollo D, et al. 2021. eLife. 0.416666666666667. PubMed
  238. Pfefferlé M, et al. 2021. Front Immunol. 12:680855. PubMed
  239. Wara AK, et al. 2020. Cell Rep. 33:108550. PubMed
  240. Fu Z, et al. 2021. Cell Res. 31:631. PubMed
  241. Kostadinova E, et al. 2016. Sci Rep. 6:30943. PubMed
  242. Tan X, et al. 2015. Sci Rep. 5: 15702. PubMed
  243. Kuwahara G, et al. 2014. PLoS One. 9:106987. PubMed
  244. Patankar Y, et al. 2013. Infect Immun . 81:2043. PubMed
  245. Kyburz A, et al. 2019. J Allergy Clin Immunol. 143:1496. PubMed
  246. Liu C et al. 2019. Immunity. 51(2):381-397 . PubMed
  247. Simula L et al. 2018. Cell reports. 25(11):3059-3073 . PubMed
  248. Tomay F, et al. 2019. J Transl Med. 17:237. PubMed
  249. Zhou J, et al. 2019. Nat Commun. 10:2427. PubMed
  250. Brown SM et al. 2017. Endocrinology. 158(10):3592-3604 . PubMed
  251. Nam GH, et al. 2018. Nat Commun. 9:2165. PubMed
  252. Zheng X, et al. 2018. J Clin Invest. 128:2104. PubMed
  253. Chung EJ, et al. 2022. Aging (Albany NY). 14:7692. PubMed
  254. Puigdelloses M, et al. 2021. J Immunother Cancer. 9:. PubMed
  255. Lang V, et al. 2021. Elife. 10:. PubMed
  256. Jaggi U, et al. 2021. PLoS Pathog. 17:e1009999. PubMed
  257. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  258. Tapia-Abellán A, et al. 2021. Sci Adv. 7:eabf4468. PubMed
  259. Henrich IC, et al. 2021. Cancer Res. 81:2171. PubMed
  260. Frenis K, et al. 2021. Basic Res Cardiol. 31:116. PubMed
  261. Lei J, et al. 2021. Theranostics. 4251:11. PubMed
  262. Dewi IMW, et al. 2021. Cell Reports Medicine. 2(5):100289. PubMed
  263. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  264. Ni J, et al. 2020. Immunity. 52(6):1075-1087.e8. PubMed
  265. Madenspacher JH, et al. 2020. JCI Insight. 5:00. PubMed
  266. Kim K, et al. 2014. Proc Natl Acad Sci U S A. 111:11774. PubMed
  267. Hu J, et al. 2015. J Hepatol. Available online 31 August 2015. PubMed
  268. Terrazas M 2014. Int J Parasit. 44 613 . PubMed
  269. Yang C, et al. 2016. Sci Rep. 6:34643. PubMed
  270. Cao Q, et al. 2019. Theranostics. 5.576388889. PubMed
  271. Li D, et al. 2022. Emerg Microbes Infect. 11:2248. PubMed
  272. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  273. Xiao Y, et al. 2022. Nat Commun. 13:758. PubMed
  274. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  275. Yu W, et al. 2022. Nat Commun. 13:3544. PubMed
  276. Li Q, et al. 2022. Front Cardiovasc Med. 9:872102. PubMed
  277. Pandit M, et al. 2021. Eur J Immunol. 51:1461. PubMed
  278. Jiang Q, et al. 2020. JCI Insight. 5:00. PubMed
  279. Kesavardhana S, et al. 2020. J Biol Chem. 295:8325. PubMed
  280. Ye ZH, et al. 2021. Transl Oncol. 14:101162. PubMed
  281. Ito T, et al. 2021. Nat Commun. 12:2232. PubMed
  282. Chen Z, et al. 2016. Nat Commun. 7:11596. PubMed
  283. Deng W, et al. 2015. Clin Immunol. . PubMed
  284. Honda H, et al. 2014. J Leukoc Biol. 96:1087. PubMed
  285. Shaw O, et al. 2014. Rheumatology. 53:1901. PubMed
  286. Rosenbaum SR, et al. 2020. Cell Rep. 30:510. PubMed
  287. Yuan X, et al. 2017. Elife. 6:e29540. PubMed
  288. Petkevicius K, et al. 2019. Elife. 8:e47990. PubMed
  289. Cianciaruso C, et al. 2020. Cell Reports. 27(10):3062-3080.e11.. PubMed
  290. Engblom C, et al. 2017. Science. 358:6367. PubMed
  291. Zhao F et al. 2018. Immunity. 48(1):147-160 . PubMed
  292. Lima-Junior D, et al. 2017. J Immunol. 10.4049/jimmunol.1700258. PubMed
  293. Pascual-Pasto G, et al. 2022. J Immunother Cancer. 10:. PubMed
  294. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  295. Zhou J, et al. 2022. Int J Oncol. 61: . PubMed
  296. Chen F, et al. 2022. Cell Rep. 38:110215. PubMed
  297. Wang S, et al. 2021. Commun Biol. 22:. PubMed
  298. Bent EH, et al. 2021. Nat Commun. 12:6218. PubMed
  299. Calle P, et al. 2021. Cells. 10:. PubMed
  300. Ishikura S, et al. 2021. J Cell Biochem. . PubMed
  301. Wang G, et al. 2021. Cell Host Microbe. 29(5):777-791.e6. PubMed
  302. Desai P, et al. 2021. Cell. 184(5):1214-1231.e16. PubMed
  303. Calderon B, et al. 2015. J Exp Med. 212: 1497-1512. PubMed
  304. Ding H, et al. 2016. Nat Commun. 7:11533. PubMed
  305. Gamradt P, et al. 2016. PLoS Pathog. 12:e1006032. PubMed
  306. Wang X, et al. 2016. J Immunol. 197(12):4750-4761. PubMed
  307. Di Genua C, et al. 2019. Haematologica. 104:2215. PubMed
  308. Horsle B 2013. Development. 140:1517. PubMed
  309. Hua X, et al. 2021. Front Immunol. 12:706027. PubMed
  310. Liu J, et al. 2021. Front Immunol. 12:733808. PubMed
  311. Feng L, et al. 2022. Signal Transduct Target Ther. 7:21. PubMed
  312. Zhang MS, et al. 2022. Nat Commun. 13:954. PubMed
  313. Pan Y, et al. 2021. Br J Pharmacol. 178:4907. PubMed
  314. Zhang H, et al. 2017. Immunol Cell Biol. 10.1038/icb.2017.11. PubMed
  315. Tian Y, et al. 2020. JCI Insight. 5:00. PubMed
  316. Kerkhofs D, et al. 2020. Theranostics. 7.022222222. PubMed
  317. Toda G, et al. 2020. Molecular Cell. 79(1):43-53.e4. PubMed
  318. Karki R, et al. 2020. bioRxiv. . PubMed
  319. Jeurissen M, et al. 2016. PLoS One. 11:e0167199. PubMed
  320. Montero-Barrera D, et al. 2015. BioMed Res Int. 2015 615865. PubMed
  321. Neimert-Andersson T, et al. 2011. Vaccine. 29:8965. PubMed
  322. Sun L, et al. 2009. FASEB J. 3.602777778. PubMed
  323. Esposito E, et al. 2019. Nat Commun. 4.101388889. PubMed
  324. Ji L et al. 2019. Immunity. 51(2):272-284 . PubMed
  325. Zhu K, et al. 2022. EMBO Rep. 23:e54499. PubMed
  326. Ding R, et al. 2022. J Neuroinflammation. 19:137. PubMed
  327. Liu R, et al. 2020. Eur J Vasc Endovasc Surg. 60:254. PubMed
  328. Zhang W, et al. 2021. Front Immunol. 12:768435. PubMed
  329. Panagi M, et al. 2020. Theranostics. 10:1910. PubMed
  330. Zhou H, et al. 2021. Cell Death Discov. 7:332. PubMed
  331. Gu H, et al. 2021. Elife. 10:. PubMed
  332. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  333. Chen C, et al. 2020. Cell Rep. 2136:30. PubMed
  334. Li K, et al. 2020. J Cell Mol Med. 24:13115. PubMed
  335. Karki R, et al. 2021. Cell. 184:149. PubMed
  336. Caoa X, et al. 2017. Neurosci Lett. 10.1016/j.neulet.2017.02.045. PubMed
  337. Mirsoian A, et al. 2014. J Exp Med. 211:2373. PubMed
  338. Yin X, et al. 2015. J Immunol. 194:4029. PubMed
  339. Kuo P, et al. 2016. J Am Heart Assoc. 5: 002610. PubMed
  340. Singh KS, et al. 2020. Nat Commun. 0.786805556. PubMed
  341. Chao Y, et al. 2020. Sci Adv. 6:eaaz4204. PubMed
  342. Chan JY, et al. 2019. Diabetologia. 62:993. PubMed
  343. Wang Z et al. 2019. Cell reports. 26(5):1273-1285 . PubMed
  344. Nishino T, et al. 2018. Arterioscler Thromb Vasc Biol. 38:2460. PubMed
  345. Meng Michelle Xu et al. 2017. Immunity. 47(2):363-373 . PubMed
  346. Adzika GK, et al. 2021. Front Cell Dev Biol. 9:719351. PubMed
  347. Santopaolo M, et al. 2021. Front Immunol. 609406:12. PubMed
  348. Chen L, et al. 2021. Theranostics. 11:6668. PubMed
  349. Zhang A, et al. 2021. Theranostics. 11:3839. PubMed
  350. Ngkelo A, et al. 2016. J Exp Med. 213: 1353 - 1374. PubMed
  351. Sockolosky J, et al. 2016. Proc Natl Acad Sci U S A. 113: 2646 - 2654. PubMed
  352. Wan X, Thomas J, Unanue E 2016. J Exp Med. 213: 967 - 978. PubMed
  353. Ishizuka M, et al. 2015. PLoS One. 10: 0137978. PubMed
  354. Pechous R, et al. 2015. MBio. 6:2302. PubMed
  355. Yin T, et al. 2015. J Immunol. 194:429. PubMed
  356. Klezovich-Bénard M, et al. 2012. PLoS One. 8:e1002481. PubMed
  357. Karpurapu M, et al. 2011. Blood. 118:5255. PubMed
  358. Yan K, et al. 2020. Cell Death Dis. 1.013888889. PubMed
  359. Eghbalzadeh K, et al. 2019. Front Immunol. 2.022916667. PubMed
  360. Ouadah Y, et al. 2019. Cell. 179:403. PubMed
  361. Ling X, et al. 2021. Biomaterials. 270:120690. PubMed
  362. Lau P, et al. 2022. Cell Mol Immunol. :. PubMed
  363. Zhou Y, et al. 2022. Theranostics. 12:5488. PubMed
  364. Sheng D, et al. 2022. J Immunother Cancer. 10:. PubMed
  365. Teng F, et al. 2021. Cell Rep. 37:110051. PubMed
  366. Adzika GK, et al. 2021. Front Cardiovasc Med. 8:719805. PubMed
  367. Wang X, et al. 2021. Theranostics. 11:209. PubMed
  368. Liu SS, et al. 2021. Immunity. :. PubMed
  369. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  370. Cao H, et al. 2020. Front Pharmacol. 11:578943. PubMed
  371. Collins C, et al. 2014. Proc Natl Acad Sci U S A. 111:9899. PubMed
  372. Bramwell K, et al. 2015. J Immunol. 195: 1647 - 1656. PubMed
  373. Legrain S, et al. 2015. J Immunol. 195: 4171 - 4175. PubMed
  374. Schuijs M, et al. 2016. PLoS One. 11: 016188. PubMed
  375. Yuan Y, et al. 2019. Clin Sci (Lond). 133:1759. PubMed
  376. Hong Y, et al. 2019. J Extracell Vesicles. 8:1670893. PubMed
  377. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  378. Kim M, et al. 2012. J Immunol. 188:4158. PubMed
  379. Saul S, et al. 2019. J Leukoc Biol. N/A. PubMed
  380. Koupenova M, et al. 2019. iScience. 19:916. PubMed
  381. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  382. Tang L, et al. 2022. Front Immunol. 12:770402. PubMed
  383. Caporarello N, et al. 2022. Nat Commun. 13:4170. PubMed
  384. Lerbs T, et al. 2020. JCI Insight. 5:00. PubMed
  385. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
  386. Wu L, et al. 2020. Cancer Immunol Res. 710:8. PubMed
  387. Fu W, et al. 2020. J Immunol Res. 8820355:2020. PubMed
  388. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  389. Malik M, et al. 2012. Proc Natl Acad Sci U S A. 109:6130. PubMed
  390. Kim SH, et al. 2020. Neoplasia. 1.3375. PubMed
  391. Maas SLN, et al. 2020. J Neuroinflammation. 17:120. PubMed
  392. Thomson CA, et al. 2018. J Immunol. 201:215. PubMed
  393. Sparber F et al. 2019. British journal of pharmacology. 176(11):1728-1744 . PubMed
  394. Lalor R, et al. 2019. Nutrients. 11. PubMed
  395. Fearon AE, et al. 2021. iScience. 24:103143. PubMed
  396. Chung EJ, et al. 2021. Int J Radiat Oncol Biol Phys. 110:526. PubMed
  397. Murray CW, et al. 2022. Nat Commun. 13:1090. PubMed
  398. Qu J, et al. 2021. Int J Biol Sci. 17:2756. PubMed
  399. Liu ZZ, et al. 2021. Front Immunol. 12:636861. PubMed
  400. Zhang B, et al. 2021. Front Neurol. 607370:12. PubMed
  401. Kapralov AA, et al. 2020. Nat Chem Biol. 278:16. PubMed
  402. Xiang W, et al. 2020. Signal Transduct Target Ther. 0.374305556. PubMed
  403. Badgujar DC, et al. 2020. PLoS Pathog. 16:e1009016. PubMed
RRID
AB_893493 (BioLegend Cat. No. 123115)
AB_893481 (BioLegend Cat. No. 123116)

Antigen Details

Structure
EGF-TM7 family member, 160 kD glycoprotein
Distribution

Majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen, Kupffer cells, Langerhans cells, bone marrow stromal cells, and a subset of dendritic cells

Function
Induction of immunological tolerance
Cell Type
Dendritic cells, Langerhans cells, Macrophages, Tregs
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Antigen References

1. Austy JM and Gordon S. 1981. Eur. J. Immunol. 11:805.
2. Hume DA, et al. 1983. J. Exp. Med. 158:1522.
3. Ruedl C, et al. 1996. Eur. J. Immunol. 26:1801.
4. McKnight AJ, et al. 1996. J. Biol. Chem. 271:486.
5. Lin HH, et al. 2005. J. Exp. Med. 201:1615.

Gene ID
13733 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
F4/80
Specificity Alt (DOES NOT SHOW ON TDS):
F4/80
App Abbreviation (DOES NOT SHOW ON TDS):
FC
Hidden Names (DOES NOT SHOW ON TDS):
F4, F80, Macrophage, Myeloid Dendritic Cell, Plasmacytoid Dendritic Cell
UniProt
View information about F4/80 on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All F4/80 Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-mouse F4/80 (Maxpar® Ready) BM8 FC,CyTOF®
PE/Dazzle™ 594 anti-mouse F4/80 BM8 FC
Brilliant Violet 650™ anti-mouse F4/80 BM8 FC
Brilliant Violet 711™ anti-mouse F4/80 BM8 FC
APC/Fire™ 750 anti-mouse F4/80 BM8 FC
TotalSeq™-A0114 anti-mouse F4/80 BM8 PG
TotalSeq™-B0114 anti-mouse F4/80 BM8 PG
TotalSeq™-C0114 anti-mouse F4/80 BM8 PG
Spark YG™ 570 anti-mouse F4/80 BM8 IHC-F
KIRAVIA Blue 520™ anti-mouse F4/80 BM8 FC
Ultra-LEAF™ Purified anti-mouse F4/80 BM8 FC,IHC,WB
Brilliant Violet 605™ anti-mouse F4/80 BM8 FC
Purified anti-mouse F4/80 BM8 FC,IHC,WB
Biotin anti-mouse F4/80 BM8 FC,IHC
FITC anti-mouse F4/80 BM8 FC
PE anti-mouse F4/80 BM8 FC
PE/Cyanine5 anti-mouse F4/80 BM8 FC
PE/Cyanine7 anti-mouse F4/80 BM8 FC
APC anti-mouse F4/80 BM8 FC
APC/Cyanine7 anti-mouse F4/80 BM8 FC
Alexa Fluor® 488 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Alexa Fluor® 647 anti-mouse F4/80 BM8 FC,IHC-F,3D IHC
Pacific Blue™ anti-mouse F4/80 BM8 FC
PerCP anti-mouse F4/80 BM8 FC
PerCP/Cyanine5.5 anti-mouse F4/80 BM8 FC
Alexa Fluor® 700 anti-mouse F4/80 BM8 FC
Brilliant Violet 421™ anti-mouse F4/80 BM8 FC,IHC-F,SB
Brilliant Violet 510™ anti-mouse F4/80 BM8 FC
Alexa Fluor® 594 anti-mouse F4/80 BM8 IHC-F
Brilliant Violet 785™ anti-mouse F4/80 BM8 FC
APC/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark NIR™ 685 anti-mouse F4/80 BM8 FC
Spark Blue™ 550 anti-mouse F4/80 BM8 FC
Brilliant Violet 570™ anti-mouse F4/80 BM8 FC
Brilliant Violet 750™ anti-mouse F4/80 BM8 FC
PE/Fire™ 810 anti-mouse F4/80 BM8 FC
Spark Red™ 718 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
Spark Blue™ 574 anti-mouse F4/80 (Flexi-Fluor™) BM8 FC
PE/Fire™ 640 anti-mouse F4/80 BM8 FC
PerCP/Fire™ 806 anti-mouse F4/80 BM8 FC
Go To Top Version: 2    Revision Date: 10/25/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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