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- Clone
- W23248A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TJP2, Zona Occludens protein 2, TJP-2, Tight Junction Protein 2, Tight junctionprotein ZO-2, Zonula occludens protein 2, X104
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 648892 | 25 µg | 152€ | ||||
| 648893 | 100 µg | 400€ | ||||
The ZO-2 protein is a key component of tight junctions. It plays a role in maintaining cell polarity and barrier function. ZO-2 interacts with other tight junction proteins like claudins and occludins and participates in signaling pathways that influence gene expression and cell proliferation. Its expression is regulated by cellular stress, cytokines, and developmental cues. Mutations in TJP2 have been associated with several diseases, including progressive familial intrahepatic cholestasis type 4 (PFIC4), familial hypercholanemia, and autosomal dominant non-syndromic hearing loss (DFNA51).
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
WB, ICC - Verified
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10.0 µg/mL is suggested. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. For immunocytochemistry, a concentration range of 1.0 - 10.0 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Additional Product Notes
-
For use of this antibody in immunohistochemistry on formalin-fixed paraffin-embedded tissues (IHC-P), we recommend antigen retrieval using Citrate Buffer (Cat. No. 420902), or Tris-EDTA pH 9.0 Antigen Retrieval Buffer (Cat. No. 422704).
For use of this antibody in Immunocytochemistry (ICC), we recommendf ixation and permeabilization using PFA-Triton X-100 or PFA-ice-cold methanol. We do not recommend ice-cold methanol only.
Antigen Details
- Structure
- The human ZO-2 protein consists of 1190 amino acids and has a molecular weight of approximately 133.9 kDa.
- Distribution
-
Tight Junction/cellular membrane/nucleus
- Interaction
- ZO-1, ZO-3, Occludin, Claudins, Band 4.1, USP53, SAFB, ZASP
- Cell Type
- Endothelial cells, Epithelial cells
- Biology Area
- Cell Biology, Cell Structure
- Molecular Family
- Adaptor Proteins, Adhesion Molecules, Gap Junction Proteins, Scaffold Proteins
- Antigen References
-
- Gonzales-Mariscal L, et al. 2019. Int J Mol Sci. 20(17):4128
- Xu J, et al. 2021. Gastroenterology. 160(6):2103.
- Kim HS, et al. 2023. Int J Mol Sci. 24(10):8801
- Ma X, et al. 2025. Redox Rep. 30(1):2493556
- Gene ID
- 9414 View all products for this Gene ID
- UniProt
- View information about ZO-2 on UniProt.org
Related FAQs
Other Formats
View All Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-ZO-2 Antibody | W23248A | IHC-P,ICC,WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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