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PE anti-human CD158z (KIR3DL3) Antibody

Pricing & Availability
Clone
S23011E (See other available formats)
Regulatory Status
RUO
Other Names
CD158z, Killer Cell Immunoglobulin-Like Receptor 3DL3, KIR44, KIRC1
Isotype
Mouse IgG2a, κ
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334911 25 tests 152€
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334912 100 tests 316€
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Description

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIMs and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.

CD158z is a glycoprotein with three extracellular Ig domains and a long cytoplasmic tail containing an ITIM motif. It is reportedly expressed on intraepithelial γδ and CD8+ T cells. KIR3DL3 has been reported to bind to HHLA2 (B7H7) to cause downstream functional inhibition.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
KIR3DL3-transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Based on in-house testing on different KIR-expressing transfectants, clone S23011E does not interact with other KIR protein family members.

Antigen Details

Structure
Three Ig-like extracellular domain glycoprotein
Distribution

Intraepithelial γδ and CD8+ T cells

Function
T Cell subset regulation
Ligand/Receptor
HHLA2
Cell Type
Lymphocytes, NK cells, T cells
Biology Area
Cell Biology, Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References
  1. Vilches C, et al. 2002. Annu. Rev. Immunol. 92.107361.
  2. Middleton D, et al. 2010. Immunol. 123:8.
  3. Bhatt RS, et al. 2021. Cancer Immunol. 2:156-169.
Gene ID
115653 View all products for this Gene ID
UniProt
View information about CD158z on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 09/29/2025

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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