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- Clone
- W24084D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- GATA4, Transcription factor GATA-4, GATA-binding factor 4, GATA4 zinc finger protein, GATA4 cardiac transcription factor
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 648705 | 25 µg | 128€ | ||||
| 648706 | 100 µg | 348€ | ||||
GATA4 is a zinc-finger transcription factor critical for heart development and function and reproductive organ development. It regulates genes involved in cardiomyocyte differentiation, heart tube formation, and chamber morphogenesis. GATA4 activity is controlled through promoter regulation, epigenetic modifications, and interactions with co-factors such as TBX5 and NKX2 5, as well as signaling pathways like BMP and TGF-β. Mutations or dysregulation of GATA4 are associated with congenital heart defects, cardiomyopathies, heart failure, and certain reproductive disorders. Emerging evidence also links GATA4 to aging-related processes and DNA damage response.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant fragment of Human GATA4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICFC -Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Additional Product Notes
-
For intracellular flow cytometry (ICFC) we recommend CytoFast™ Fix/Perm Buffer Set (Cat. No. 426803) for fixation and permeabilization.
Antigen Details
- Structure
- GATA4 protein is 442 amino acids long, with a molecular weight of 44.5 kDa.
- Distribution
-
Nucleus
- Interaction
- NKX2-5, TBX5, FOG2, MEF2C, SRF, HAND2, SMAD proteins, EP300
- Antigen References
-
- Zhou P, et al. 2022. Circ Res. 131:e152.
- Torres L, et al. 2023. Immunity. 56:1
- Zhang Y, et al. 2017. Medicine. 96:e6857
- Khalid AB, et al. 2021. Bone. 144:115819.
- Gene ID
- 2626 View all products for this Gene ID
- UniProt
- View information about GATA4 on UniProt.org
Related FAQs
Other Formats
View All GATA4 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-GATA4 | W24084D | WB,ICFC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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