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APC/Cyanine7 anti-mouse Ly-6C Antibody APC/Cyanine7 anti-mouse Ly-6C Antibody

Pricing & Availability
Clone
HK1.4 (See other available formats)
Regulatory Status
RUO
Other Names
Lymphocyte antigen 6 complex, locus C
Isotype
Rat IgG2c, κ
Ave. Rating
Submit a Review
Product Citations
publications
HK1-4_APCCyanine7_Ly-6C_Antibody_020119
C57BL/6 mouse bone marrow cells were stained with CD8a FITC and Ly-6C (clone HK1.4) APC/Cyanine7 (left) or Rat IgG2a, κ APC/Cyanine7 isotype control (right).
  • HK1-4_APCCyanine7_Ly-6C_Antibody_020119
    C57BL/6 mouse bone marrow cells were stained with CD8a FITC and Ly-6C (clone HK1.4) APC/Cyanine7 (left) or Rat IgG2a, κ APC/Cyanine7 isotype control (right).
Compare all formats See APC/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability Save
128026 100 µg NOK2566
Check Availability


Need larger quantities of this item?
Request Bulk Quote
128025 25 µg NOK1065
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Need larger quantities of this item?
Request Bulk Quote
Description

Most hematopoietic cells express one or more members of Ly-6 family. The expression of Ly-6 varies with development stage and activation. Ly-6C is a 14-17 kD GPI-linked surface protein expressed on mouse monocyte/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. Ly-6C is reported to be an indicator of memory CD8+ T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
L3 cloned CTL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is =0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone HK1.4 does not block the binding of clone RB6-8C58.

Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells1-3 and immunohistochemistry of frozen sections4.

Application References
  1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819. (Activ)
  2. Herold KC, et al. 1990. Diabetes 39:815. (Activ)
  3. Havran WL, et al. 1988. J. Immunol. 140:1034 (Activ)
  4. Flanagan K, et al. 2008. J. Immunol. 180:3874. (IHC)
  5. Makaroff LE, et al. 2009. P. Natl. Acad. Sci. USA 106:4799. (FC)
  6. Zuber J, et al. 2009. Genes Dev. 23:877. (FC) PubMed
  7. Ribechini E, et al. 2009. Eur. J. Immunol. 39:3538.
  8. Ma C, et al. 2012. J. Leukoc. Biol. 92:1199.
  9. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
Product Citations
  1. Parsons M, et al. 2014. J Immunol. 192:1361. PubMed
  2. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  3. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  4. Tessaro FHG, et al. 2022. Cell Rep. 39:110977. PubMed
  5. Zhang X, et al. 2022. EBioMedicine. 84:104275. PubMed
  6. Hao J, et al. 2022. Cell Rep. 41:111804. PubMed
  7. Ullah I, et al. 2023. Cell Rep Med. 4:100893. PubMed
  8. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  9. Sieow JL, et al. 2023. Int J Mol Sci. 24: . PubMed
  10. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  11. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  12. Zhang Q, et al. 2022. Nat Metab. 4:1055. PubMed
  13. Olofsen PA, et al. 2022. Cells. 11:. PubMed
  14. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  15. Tang C, et al. 2023. Nat Commun. 14:1493. PubMed
  16. Dijkman K, et al. 2023. NPJ Vaccines. 8:66. PubMed
  17. Ippagunta S, et al. 2016. Proc Natl Acad Sci U S A. 113: E6162 - E6171. PubMed
  18. He J, et al. 2022. Front Immunol. 12:760138. PubMed
  19. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  20. Abdala-Valencia H, et al. 2014. Am J Physiol Lung Cell Mol Physiol. 307:482. PubMed
  21. Kim AS, et al. 2021. Cell. 184(17):4414-4429.e19. PubMed
  22. Heng Y, et al. 2020. Glia. . PubMed
  23. Rodriguez-García A, et al. 2021. Nat Commun. 12:877. PubMed
  24. Súarez-López L, et al. 2021. iScience. 24:103406. PubMed
  25. Sun CP, et al. 2021. PLoS Pathog. 17:e1009758. PubMed
  26. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  27. Devalaraja S, et al. 2020. Cell. 1098:180. PubMed
  28. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  29. Chan YH, et al. 2019. EMBO Mol Med. 11:e10092. PubMed
  30. Lin T, et al. 2015. PLoS One. 10: e0138335. PubMed
  31. Wada N, et al. 2020. Mol Metab. 37:100988. PubMed
  32. Motoyama S, et al. 2020. Cells. :9. PubMed
  33. Tanner MA, et al. 2021. Am J Physiol Heart Circ Physiol. 321:H633. PubMed
  34. McDowell SAC, et al. 2021. Nat Cancer. 2:545. PubMed
  35. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  36. Royzman D, et al. 2022. Front Immunol. 13:1012647. PubMed
  37. Movita D, et al. 2015. J Virol. 89:4809. PubMed
  38. Walker FC, et al. 2021. PLoS Pathog. 17:e1009402. PubMed
  39. Fujita K, et al. 2019. Proc Natl Acad Sci U S A. 116:14714. PubMed
  40. Devalaraja S, et al. 2020. STAR Protoc. 1:100188. PubMed
  41. Hou X, et al. 2022. Cell Death Dis. 13:100. PubMed
  42. Domingos-Pereira S, et al. 2019. Cancer Immunol Res. 7:621. PubMed
  43. Yu S, et al. 2016. Mol Ther. 10.1038/mt.2016.175. PubMed
  44. Yin S, et al. 2016. Nat Commun. 7: 11311. PubMed
  45. Lim HY et al. 2018. Immunity. 49(2):326-341 . PubMed
  46. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  47. Neupane AS, et al. 2020. Cell. 183(1):110-125.e11. PubMed
  48. Abdul Pari AA, et al. 2020. Cancer Res. 80:2586. PubMed
  49. Wang Y, et al. 2021. Cell Rep. 35:108948. PubMed
  50. Formaglio P, et al. 2021. Immunity. 54:2724. PubMed
  51. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  52. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  53. McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
  54. Bambouskova M, et al. 2021. Cell Reports. 34(10):108756. PubMed
  55. AM C, et al. 2015. Proc Natl Acad Sci U S A. 112 7557 . PubMed
  56. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  57. Kuhn JA, et al. 2021. Elife. 10:. PubMed
  58. Simões FC, et al. 2020. Nat Commun. 0.875. PubMed
  59. Luo J et al. 2018. Immunity. 49(1):107-119 . PubMed
  60. Liu X, et al. 2020. Cell Host Microbe. 28(5):683-698.e6. PubMed
  61. Grauel AL, et al. 2020. Nat Commun. 4.84375. PubMed
  62. Lee L, et al. 2016. PLoS One. 11:e0167693. PubMed
  63. Maisel D, et al. 2016. PLoS One. 11: 0159716. PubMed
  64. Lin J, et al. 2021. Nat Commun. 12:5321. PubMed
  65. Terauchi R, et al. 2021. PLoS One. 16:e0239108. PubMed
  66. Wang SK, et al. 2021. JCI Insight. 6: . PubMed
  67. Mossadegh–Keller N, et al. 2019. Bio Protoc. 9:5. PubMed
  68. Mohamed E, et al. 2020. Immunity. 52(4):668-682.e7.. PubMed
  69. Shepardson K, et al. 2016. MBio. 7: e00506-16. PubMed
  70. Alam Z, et al. 2020. Cell Rep. 107825:31. PubMed
  71. de Laval B, et al. 2020. Cell Stem Cell. 26(5):657-674. PubMed
  72. Swanson P, et al. 2016. PLoS Pathog. 12:e1006022. PubMed
  73. Capuccini B, et al. 2016. Sci Rep. 6:39258. PubMed
  74. Olson B, et al. 2021. Brain Behav Immun. 97:102. PubMed
  75. Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed
  76. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  77. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  78. Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
  79. Mulens-Arias V, et al. 2022. Pharmaceutics. 14:. PubMed
  80. Buerfent BC, et al. 2019. GMS Infect Dis. 7:Doc04. PubMed
  81. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  82. Nicolas-Boluda A, et al. 2021. eLife. 10:00. PubMed
  83. Fedele C, et al. 2021. J Exp Med. 218: . PubMed
  84. Baker GJ, et al. 2020. Cell Syst. 0.647222222. PubMed
  85. Kwok I, et al. 2020. Immunity. 53(2):303-318.e5. PubMed
  86. van de Garde M, et al. 2016. PLoS One. 11:e0166094. PubMed
  87. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  88. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  89. Zhang X, et al. 2020. Glia. . PubMed
  90. Lynn GM, et al. 2020. Nat Biotechnol. 38:320. PubMed
  91. Parsons M, et al. 2014. J Immunol. 192:1361. PubMed
  92. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  93. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  94. Tessaro FHG, et al. 2022. Cell Rep. 39:110977. PubMed
  95. Zhang X, et al. 2022. EBioMedicine. 84:104275. PubMed
  96. Hao J, et al. 2022. Cell Rep. 41:111804. PubMed
  97. Ullah I, et al. 2023. Cell Rep Med. 4:100893. PubMed
  98. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  99. Sieow JL, et al. 2023. Int J Mol Sci. 24: . PubMed
  100. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  101. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  102. Zhang Q, et al. 2022. Nat Metab. 4:1055. PubMed
  103. Olofsen PA, et al. 2022. Cells. 11:. PubMed
  104. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  105. Tang C, et al. 2023. Nat Commun. 14:1493. PubMed
  106. Dijkman K, et al. 2023. NPJ Vaccines. 8:66. PubMed
  107. Ippagunta S, et al. 2016. Proc Natl Acad Sci U S A. 113: E6162 - E6171. PubMed
  108. He J, et al. 2022. Front Immunol. 12:760138. PubMed
  109. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  110. Abdala-Valencia H, et al. 2014. Am J Physiol Lung Cell Mol Physiol. 307:482. PubMed
  111. Kim AS, et al. 2021. Cell. 184(17):4414-4429.e19. PubMed
  112. Heng Y, et al. 2020. Glia. . PubMed
  113. Rodriguez-García A, et al. 2021. Nat Commun. 12:877. PubMed
  114. Súarez-López L, et al. 2021. iScience. 24:103406. PubMed
  115. Sun CP, et al. 2021. PLoS Pathog. 17:e1009758. PubMed
  116. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  117. Devalaraja S, et al. 2020. Cell. 1098:180. PubMed
  118. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  119. Chan YH, et al. 2019. EMBO Mol Med. 11:e10092. PubMed
  120. Lin T, et al. 2015. PLoS One. 10: e0138335. PubMed
  121. Wada N, et al. 2020. Mol Metab. 37:100988. PubMed
  122. Motoyama S, et al. 2020. Cells. :9. PubMed
  123. Tanner MA, et al. 2021. Am J Physiol Heart Circ Physiol. 321:H633. PubMed
  124. McDowell SAC, et al. 2021. Nat Cancer. 2:545. PubMed
  125. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  126. Royzman D, et al. 2022. Front Immunol. 13:1012647. PubMed
  127. Movita D, et al. 2015. J Virol. 89:4809. PubMed
  128. Walker FC, et al. 2021. PLoS Pathog. 17:e1009402. PubMed
  129. Fujita K, et al. 2019. Proc Natl Acad Sci U S A. 116:14714. PubMed
  130. Devalaraja S, et al. 2020. STAR Protoc. 1:100188. PubMed
  131. Hou X, et al. 2022. Cell Death Dis. 13:100. PubMed
  132. Domingos-Pereira S, et al. 2019. Cancer Immunol Res. 7:621. PubMed
  133. Yu S, et al. 2016. Mol Ther. 10.1038/mt.2016.175. PubMed
  134. Yin S, et al. 2016. Nat Commun. 7: 11311. PubMed
  135. Lim HY et al. 2018. Immunity. 49(2):326-341 . PubMed
  136. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  137. Neupane AS, et al. 2020. Cell. 183(1):110-125.e11. PubMed
  138. Abdul Pari AA, et al. 2020. Cancer Res. 80:2586. PubMed
  139. Wang Y, et al. 2021. Cell Rep. 35:108948. PubMed
  140. Formaglio P, et al. 2021. Immunity. 54:2724. PubMed
  141. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  142. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  143. McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
  144. Bambouskova M, et al. 2021. Cell Reports. 34(10):108756. PubMed
  145. AM C, et al. 2015. Proc Natl Acad Sci U S A. 112 7557 . PubMed
  146. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  147. Kuhn JA, et al. 2021. Elife. 10:. PubMed
  148. Simões FC, et al. 2020. Nat Commun. 0.875. PubMed
  149. Luo J et al. 2018. Immunity. 49(1):107-119 . PubMed
  150. Liu X, et al. 2020. Cell Host Microbe. 28(5):683-698.e6. PubMed
  151. Grauel AL, et al. 2020. Nat Commun. 4.84375. PubMed
  152. Lee L, et al. 2016. PLoS One. 11:e0167693. PubMed
  153. Maisel D, et al. 2016. PLoS One. 11: 0159716. PubMed
  154. Lin J, et al. 2021. Nat Commun. 12:5321. PubMed
  155. Terauchi R, et al. 2021. PLoS One. 16:e0239108. PubMed
  156. Wang SK, et al. 2021. JCI Insight. 6: . PubMed
  157. Mossadegh–Keller N, et al. 2019. Bio Protoc. 9:5. PubMed
  158. Mohamed E, et al. 2020. Immunity. 52(4):668-682.e7.. PubMed
  159. Shepardson K, et al. 2016. MBio. 7: e00506-16. PubMed
  160. Alam Z, et al. 2020. Cell Rep. 107825:31. PubMed
  161. de Laval B, et al. 2020. Cell Stem Cell. 26(5):657-674. PubMed
  162. Swanson P, et al. 2016. PLoS Pathog. 12:e1006022. PubMed
  163. Capuccini B, et al. 2016. Sci Rep. 6:39258. PubMed
  164. Olson B, et al. 2021. Brain Behav Immun. 97:102. PubMed
  165. Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed
  166. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  167. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  168. Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
  169. Mulens-Arias V, et al. 2022. Pharmaceutics. 14:. PubMed
  170. Buerfent BC, et al. 2019. GMS Infect Dis. 7:Doc04. PubMed
  171. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  172. Nicolas-Boluda A, et al. 2021. eLife. 10:00. PubMed
  173. Fedele C, et al. 2021. J Exp Med. 218: . PubMed
  174. Baker GJ, et al. 2020. Cell Syst. 0.647222222. PubMed
  175. Kwok I, et al. 2020. Immunity. 53(2):303-318.e5. PubMed
  176. van de Garde M, et al. 2016. PLoS One. 11:e0166094. PubMed
  177. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  178. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  179. Zhang X, et al. 2020. Glia. . PubMed
  180. Lynn GM, et al. 2020. Nat Biotechnol. 38:320. PubMed
RRID
AB_10640120 (BioLegend Cat. No. 128026)
AB_10643867 (BioLegend Cat. No. 128025)

Antigen Details

Structure
14-17 kD protein (134 amino acids), member of the Ly-6 family of GPI linked protein. Ly6 family members share structure homology throughout a distinctive cystein rich protein domain that incorporates O-linked carbohydrates.
Distribution

Ly-6C is expressed primarily on bone marrow myeloid populations, monocytes/macrophages, neutrophils, endothelial cells, and some T cell subsets. Ly-6C is also a marker of memory CD8+ T cells.

Cell Type
Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819.
2. Cerwenka A, et al. 1998. J. Immunol. 161:97.

Gene ID
17067 View all products for this Gene ID
UniProt
View information about Ly-6C on UniProt.org

Related FAQs

There are no FAQs for this product.

Other Formats

View All Ly-6C Reagents Request Custom Conjugation
Description Clone Applications
Pacific Blue™ anti-mouse Ly-6C HK1.4 FC
APC anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C HK1.4 FC,IHC-F
Biotin anti-mouse Ly-6C HK1.4 FC
FITC anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 647 anti-mouse Ly-6C HK1.4 FC
PE anti-mouse Ly-6C HK1.4 FC
PerCP/Cyanine5.5 anti-mouse Ly-6C HK1.4 FC
PE/Cyanine7 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 488 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 700 anti-mouse Ly-6C HK1.4 FC
APC/Cyanine7 anti-mouse Ly-6C HK1.4 FC
PerCP anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 570™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 421™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 510™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 605™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 711™ anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C (Maxpar® Ready) HK1.4 FC,CyTOF®
Brilliant Violet 785™ anti-mouse Ly-6C HK1.4 FC
PE/Dazzle™ 594 anti-mouse Ly-6C HK1.4 FC
APC/Fire™ 750 anti-mouse Ly-6C HK1.4 FC
TotalSeq™-A0013 anti-mouse Ly-6C HK1.4 PG
Brilliant Violet 650™ anti-mouse Ly-6C HK1.4 FC
TotalSeq™-C0013 anti-mouse Ly-6C HK1.4 PG
TotalSeq™-B0013 anti-mouse Ly-6C HK1.4 PG
APC/Fire™ 810 anti-mouse Ly-6C Antibody HK1.4 FC
Spark Red™ 718 anti-mouse Ly-6C HK1.4 FC
Spark UV™ 387 anti-mouse Ly-6C HK1.4 FC
PE/Fire™ 810 anti-mouse Ly-6C HK1.4 FC
Spark Blue™ 550 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark Blue™ 574 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
PE/Cyanine5 anti-mouse Ly-6C HK1.4 FC
Spark PLUS B550™ anti-mouse Ly-6C HK1.4 FC
PerCP/Fire™ 806 anti-mouse Ly-6c Antibody HK1.4 FC
Spark YG™ 581 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark YG™ 593 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Spark NIR™ 685 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Go To Top Version: 3    Revision Date: 02.01.2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
HK1.4 (See other available formats)
Regulatory Status
RUO
Other Names
Lymphocyte antigen 6 complex, locus C
Isotype
Rat IgG2c, κ
Ave. Rating
Submit a Review
Product Citations
publications
HK1-4_APCCyanine7_Ly-6C_Antibody_020119
C57BL/6 mouse bone marrow cells were stained with CD8a FITC and Ly-6C (clone HK1.4) APC/Cyanine7 (left) or Rat IgG2a, κ APC/Cyanine7 isotype control (right).
  • HK1-4_APCCyanine7_Ly-6C_Antibody_020119
    C57BL/6 mouse bone marrow cells were stained with CD8a FITC and Ly-6C (clone HK1.4) APC/Cyanine7 (left) or Rat IgG2a, κ APC/Cyanine7 isotype control (right).
Compare all formats See APC/Cyanine7 spectral data
Cat # Size Price Quantity Check Availability Save
128026 100 µg NOK2566
Check Availability


Need larger quantities of this item?
Request Bulk Quote
128025 25 µg NOK1065
Check Availability


Need larger quantities of this item?
Request Bulk Quote
Description

Most hematopoietic cells express one or more members of Ly-6 family. The expression of Ly-6 varies with development stage and activation. Ly-6C is a 14-17 kD GPI-linked surface protein expressed on mouse monocyte/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. Ly-6C is reported to be an indicator of memory CD8+ T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
L3 cloned CTL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is =0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application Notes

Clone HK1.4 does not block the binding of clone RB6-8C58.

Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells1-3 and immunohistochemistry of frozen sections4.

Application References
  1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819. (Activ)
  2. Herold KC, et al. 1990. Diabetes 39:815. (Activ)
  3. Havran WL, et al. 1988. J. Immunol. 140:1034 (Activ)
  4. Flanagan K, et al. 2008. J. Immunol. 180:3874. (IHC)
  5. Makaroff LE, et al. 2009. P. Natl. Acad. Sci. USA 106:4799. (FC)
  6. Zuber J, et al. 2009. Genes Dev. 23:877. (FC) PubMed
  7. Ribechini E, et al. 2009. Eur. J. Immunol. 39:3538.
  8. Ma C, et al. 2012. J. Leukoc. Biol. 92:1199.
  9. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
Product Citations
  1. Parsons M, et al. 2014. J Immunol. 192:1361. PubMed
  2. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  3. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  4. Tessaro FHG, et al. 2022. Cell Rep. 39:110977. PubMed
  5. Zhang X, et al. 2022. EBioMedicine. 84:104275. PubMed
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  9. Sieow JL, et al. 2023. Int J Mol Sci. 24: . PubMed
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  16. Dijkman K, et al. 2023. NPJ Vaccines. 8:66. PubMed
  17. Ippagunta S, et al. 2016. Proc Natl Acad Sci U S A. 113: E6162 - E6171. PubMed
  18. He J, et al. 2022. Front Immunol. 12:760138. PubMed
  19. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  20. Abdala-Valencia H, et al. 2014. Am J Physiol Lung Cell Mol Physiol. 307:482. PubMed
  21. Kim AS, et al. 2021. Cell. 184(17):4414-4429.e19. PubMed
  22. Heng Y, et al. 2020. Glia. . PubMed
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  24. Súarez-López L, et al. 2021. iScience. 24:103406. PubMed
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  46. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  47. Neupane AS, et al. 2020. Cell. 183(1):110-125.e11. PubMed
  48. Abdul Pari AA, et al. 2020. Cancer Res. 80:2586. PubMed
  49. Wang Y, et al. 2021. Cell Rep. 35:108948. PubMed
  50. Formaglio P, et al. 2021. Immunity. 54:2724. PubMed
  51. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  52. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  53. McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
  54. Bambouskova M, et al. 2021. Cell Reports. 34(10):108756. PubMed
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  60. Liu X, et al. 2020. Cell Host Microbe. 28(5):683-698.e6. PubMed
  61. Grauel AL, et al. 2020. Nat Commun. 4.84375. PubMed
  62. Lee L, et al. 2016. PLoS One. 11:e0167693. PubMed
  63. Maisel D, et al. 2016. PLoS One. 11: 0159716. PubMed
  64. Lin J, et al. 2021. Nat Commun. 12:5321. PubMed
  65. Terauchi R, et al. 2021. PLoS One. 16:e0239108. PubMed
  66. Wang SK, et al. 2021. JCI Insight. 6: . PubMed
  67. Mossadegh–Keller N, et al. 2019. Bio Protoc. 9:5. PubMed
  68. Mohamed E, et al. 2020. Immunity. 52(4):668-682.e7.. PubMed
  69. Shepardson K, et al. 2016. MBio. 7: e00506-16. PubMed
  70. Alam Z, et al. 2020. Cell Rep. 107825:31. PubMed
  71. de Laval B, et al. 2020. Cell Stem Cell. 26(5):657-674. PubMed
  72. Swanson P, et al. 2016. PLoS Pathog. 12:e1006022. PubMed
  73. Capuccini B, et al. 2016. Sci Rep. 6:39258. PubMed
  74. Olson B, et al. 2021. Brain Behav Immun. 97:102. PubMed
  75. Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed
  76. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  77. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  78. Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
  79. Mulens-Arias V, et al. 2022. Pharmaceutics. 14:. PubMed
  80. Buerfent BC, et al. 2019. GMS Infect Dis. 7:Doc04. PubMed
  81. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  82. Nicolas-Boluda A, et al. 2021. eLife. 10:00. PubMed
  83. Fedele C, et al. 2021. J Exp Med. 218: . PubMed
  84. Baker GJ, et al. 2020. Cell Syst. 0.647222222. PubMed
  85. Kwok I, et al. 2020. Immunity. 53(2):303-318.e5. PubMed
  86. van de Garde M, et al. 2016. PLoS One. 11:e0166094. PubMed
  87. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  88. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  89. Zhang X, et al. 2020. Glia. . PubMed
  90. Lynn GM, et al. 2020. Nat Biotechnol. 38:320. PubMed
  91. Parsons M, et al. 2014. J Immunol. 192:1361. PubMed
  92. Sun L, et al. 2021. Cancer Cell. 39:1361. PubMed
  93. Martin-Martin I, et al. 2022. Cell Rep. 39:110648. PubMed
  94. Tessaro FHG, et al. 2022. Cell Rep. 39:110977. PubMed
  95. Zhang X, et al. 2022. EBioMedicine. 84:104275. PubMed
  96. Hao J, et al. 2022. Cell Rep. 41:111804. PubMed
  97. Ullah I, et al. 2023. Cell Rep Med. 4:100893. PubMed
  98. Domingos-Pereira S, et al. 2022. Int J Mol Sci. 24: . PubMed
  99. Sieow JL, et al. 2023. Int J Mol Sci. 24: . PubMed
  100. Yang L, et al. 2023. Acta Pharmacol Sin. :. PubMed
  101. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  102. Zhang Q, et al. 2022. Nat Metab. 4:1055. PubMed
  103. Olofsen PA, et al. 2022. Cells. 11:. PubMed
  104. Zhao Q, et al. 2023. Signal Transduct Target Ther. 8:40. PubMed
  105. Tang C, et al. 2023. Nat Commun. 14:1493. PubMed
  106. Dijkman K, et al. 2023. NPJ Vaccines. 8:66. PubMed
  107. Ippagunta S, et al. 2016. Proc Natl Acad Sci U S A. 113: E6162 - E6171. PubMed
  108. He J, et al. 2022. Front Immunol. 12:760138. PubMed
  109. Chou YJ, et al. 2020. Sci Rep. 10:8422. PubMed
  110. Abdala-Valencia H, et al. 2014. Am J Physiol Lung Cell Mol Physiol. 307:482. PubMed
  111. Kim AS, et al. 2021. Cell. 184(17):4414-4429.e19. PubMed
  112. Heng Y, et al. 2020. Glia. . PubMed
  113. Rodriguez-García A, et al. 2021. Nat Commun. 12:877. PubMed
  114. Súarez-López L, et al. 2021. iScience. 24:103406. PubMed
  115. Sun CP, et al. 2021. PLoS Pathog. 17:e1009758. PubMed
  116. Álvaro de Mingo Pulido et al. 2018. Cancer cell. 33(1):60-74 . PubMed
  117. Devalaraja S, et al. 2020. Cell. 1098:180. PubMed
  118. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
  119. Chan YH, et al. 2019. EMBO Mol Med. 11:e10092. PubMed
  120. Lin T, et al. 2015. PLoS One. 10: e0138335. PubMed
  121. Wada N, et al. 2020. Mol Metab. 37:100988. PubMed
  122. Motoyama S, et al. 2020. Cells. :9. PubMed
  123. Tanner MA, et al. 2021. Am J Physiol Heart Circ Physiol. 321:H633. PubMed
  124. McDowell SAC, et al. 2021. Nat Cancer. 2:545. PubMed
  125. Zhou HF, et al. 2022. Front Pharmacol. 13:778755. PubMed
  126. Royzman D, et al. 2022. Front Immunol. 13:1012647. PubMed
  127. Movita D, et al. 2015. J Virol. 89:4809. PubMed
  128. Walker FC, et al. 2021. PLoS Pathog. 17:e1009402. PubMed
  129. Fujita K, et al. 2019. Proc Natl Acad Sci U S A. 116:14714. PubMed
  130. Devalaraja S, et al. 2020. STAR Protoc. 1:100188. PubMed
  131. Hou X, et al. 2022. Cell Death Dis. 13:100. PubMed
  132. Domingos-Pereira S, et al. 2019. Cancer Immunol Res. 7:621. PubMed
  133. Yu S, et al. 2016. Mol Ther. 10.1038/mt.2016.175. PubMed
  134. Yin S, et al. 2016. Nat Commun. 7: 11311. PubMed
  135. Lim HY et al. 2018. Immunity. 49(2):326-341 . PubMed
  136. Guérin MV, et al. 2019. Nat Commun. 10:4131. PubMed
  137. Neupane AS, et al. 2020. Cell. 183(1):110-125.e11. PubMed
  138. Abdul Pari AA, et al. 2020. Cancer Res. 80:2586. PubMed
  139. Wang Y, et al. 2021. Cell Rep. 35:108948. PubMed
  140. Formaglio P, et al. 2021. Immunity. 54:2724. PubMed
  141. Dmitrieva‐Posocco O et al. 2019. Immunity. 50(1):166-180 . PubMed
  142. Witkowski MT, et al. 2020. Cancer Cell. 37:867. PubMed
  143. McFarland AP, et al. 2021. Immunity. 54(6):1320-1337.e4. PubMed
  144. Bambouskova M, et al. 2021. Cell Reports. 34(10):108756. PubMed
  145. AM C, et al. 2015. Proc Natl Acad Sci U S A. 112 7557 . PubMed
  146. , et al. 2021. Eur J Immunol. 51:2708. PubMed
  147. Kuhn JA, et al. 2021. Elife. 10:. PubMed
  148. Simões FC, et al. 2020. Nat Commun. 0.875. PubMed
  149. Luo J et al. 2018. Immunity. 49(1):107-119 . PubMed
  150. Liu X, et al. 2020. Cell Host Microbe. 28(5):683-698.e6. PubMed
  151. Grauel AL, et al. 2020. Nat Commun. 4.84375. PubMed
  152. Lee L, et al. 2016. PLoS One. 11:e0167693. PubMed
  153. Maisel D, et al. 2016. PLoS One. 11: 0159716. PubMed
  154. Lin J, et al. 2021. Nat Commun. 12:5321. PubMed
  155. Terauchi R, et al. 2021. PLoS One. 16:e0239108. PubMed
  156. Wang SK, et al. 2021. JCI Insight. 6: . PubMed
  157. Mossadegh–Keller N, et al. 2019. Bio Protoc. 9:5. PubMed
  158. Mohamed E, et al. 2020. Immunity. 52(4):668-682.e7.. PubMed
  159. Shepardson K, et al. 2016. MBio. 7: e00506-16. PubMed
  160. Alam Z, et al. 2020. Cell Rep. 107825:31. PubMed
  161. de Laval B, et al. 2020. Cell Stem Cell. 26(5):657-674. PubMed
  162. Swanson P, et al. 2016. PLoS Pathog. 12:e1006022. PubMed
  163. Capuccini B, et al. 2016. Sci Rep. 6:39258. PubMed
  164. Olson B, et al. 2021. Brain Behav Immun. 97:102. PubMed
  165. Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed
  166. Alexander Mildner et al. 2017. Immunity. 46(5):849-862 . PubMed
  167. Bellomo A, et al. 2020. Immunity. 53(1):127-142.e7. PubMed
  168. Walker MT, et al. 2021. Front. Allergy. 2:. PubMed
  169. Mulens-Arias V, et al. 2022. Pharmaceutics. 14:. PubMed
  170. Buerfent BC, et al. 2019. GMS Infect Dis. 7:Doc04. PubMed
  171. Clemente–Casares X, et al. 2017. Immunity. 47:974. PubMed
  172. Nicolas-Boluda A, et al. 2021. eLife. 10:00. PubMed
  173. Fedele C, et al. 2021. J Exp Med. 218: . PubMed
  174. Baker GJ, et al. 2020. Cell Syst. 0.647222222. PubMed
  175. Kwok I, et al. 2020. Immunity. 53(2):303-318.e5. PubMed
  176. van de Garde M, et al. 2016. PLoS One. 11:e0166094. PubMed
  177. Heyde A, et al. 2021. Cell. 184(5):1348-1361.e22. PubMed
  178. Gardner A, et al. 2022. J Immunother Cancer. 10:. PubMed
  179. Zhang X, et al. 2020. Glia. . PubMed
  180. Lynn GM, et al. 2020. Nat Biotechnol. 38:320. PubMed
RRID
AB_10640120 (BioLegend Cat. No. 128026)
AB_10643867 (BioLegend Cat. No. 128025)

Antigen Details

Structure
14-17 kD protein (134 amino acids), member of the Ly-6 family of GPI linked protein. Ly6 family members share structure homology throughout a distinctive cystein rich protein domain that incorporates O-linked carbohydrates.
Distribution

Ly-6C is expressed primarily on bone marrow myeloid populations, monocytes/macrophages, neutrophils, endothelial cells, and some T cell subsets. Ly-6C is also a marker of memory CD8+ T cells.

Cell Type
Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819.
2. Cerwenka A, et al. 1998. J. Immunol. 161:97.

Gene ID
17067 View all products for this Gene ID
UniProt
View information about Ly-6C on UniProt.org

Other Formats

View All Ly-6C Reagents Request Custom Conjugation
Description Clone Applications
Pacific Blue™ anti-mouse Ly-6C HK1.4 FC
APC anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C HK1.4 FC,IHC-F
Biotin anti-mouse Ly-6C HK1.4 FC
FITC anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 647 anti-mouse Ly-6C HK1.4 FC
PE anti-mouse Ly-6C HK1.4 FC
PerCP/Cyanine5.5 anti-mouse Ly-6C HK1.4 FC
PE/Cyanine7 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 488 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 700 anti-mouse Ly-6C HK1.4 FC
APC/Cyanine7 anti-mouse Ly-6C HK1.4 FC
PerCP anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 570™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 421™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 510™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 605™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 711™ anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C (Maxpar® Ready) HK1.4 FC,CyTOF®
Brilliant Violet 785™ anti-mouse Ly-6C HK1.4 FC
PE/Dazzle™ 594 anti-mouse Ly-6C HK1.4 FC
APC/Fire™ 750 anti-mouse Ly-6C HK1.4 FC
TotalSeq™-A0013 anti-mouse Ly-6C HK1.4 PG
Brilliant Violet 650™ anti-mouse Ly-6C HK1.4 FC
TotalSeq™-C0013 anti-mouse Ly-6C HK1.4 PG
TotalSeq™-B0013 anti-mouse Ly-6C HK1.4 PG
APC/Fire™ 810 anti-mouse Ly-6C Antibody HK1.4 FC
Spark Red™ 718 anti-mouse Ly-6C HK1.4 FC
Spark UV™ 387 anti-mouse Ly-6C HK1.4 FC
PE/Fire™ 810 anti-mouse Ly-6C HK1.4 FC
Spark Blue™ 550 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark Blue™ 574 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
PE/Cyanine5 anti-mouse Ly-6C HK1.4 FC
Spark PLUS B550™ anti-mouse Ly-6C HK1.4 FC
PerCP/Fire™ 806 anti-mouse Ly-6c Antibody HK1.4 FC
Spark YG™ 581 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark YG™ 593 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Spark NIR™ 685 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Go To Top Version: 3    Revision Date: 02.01.2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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