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PerCP/Cyanine5.5 anti-mouse Ly-6C Antibody PerCP/Cyanine5.5 anti-mouse Ly-6C Antibody

Pricing & Availability
Clone
HK1.4 (See other available formats)
Regulatory Status
RUO
Other Names
Lymphocyte antigen 6 complex, locus C
Isotype
Rat IgG2c, κ
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Product Citations
publications
HK1dot4_PerCPCy55_061909.jpg
C57BL/6 bone marrow cells stained with HK1.4 PerCP/Cyanine5.5
  • HK1dot4_PerCPCy55_061909.jpg
    C57BL/6 bone marrow cells stained with HK1.4 PerCP/Cyanine5.5
Compare all formats See PerCP/Cyanine5.5 spectral data
Cat # Size Price Quantity Check Availability Save
128012 100 µg NOK2764
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128011 25 µg NOK1164
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Description

Most hematopoietic cells express one or more members of Ly-6 family. The expression of Ly-6 varies with development stage and activation. Ly-6C is a 14-17 kD GPI-linked surface protein expressed on mouse monocyte/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. Ly-6C is reported to be an indicator of memory CD8+ T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
L3 cloned CTL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PerCP/Cyanine5.5 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

Application Notes

Clone HK1.4 does not block the binding of clone RB6-8C58.

Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells1-3 and immunohistochemistry of frozen sections4.

Application References
  1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819. (Activ)
  2. Herold KC, et al. 1990. Diabetes 39:815. (Activ)
  3. Havran WL, et al. 1988. J. Immunol. 140:1034 (Activ)
  4. Flanagan K, et al. 2008. J. Immunol. 180:3874. (IHC)
  5. Makaroff LE, et al. 2009. P. Natl. Acad. Sci. USA 106:4799. (FC)
  6. Zuber J, et al. 2009. Genes Dev. 23:877. (FC) PubMed
  7. Ribechini E, et al. 2009. Eur. J. Immunol. 39:3538.
  8. Ma C, et al. 2012. J. Leukoc. Biol. 92:1199.
  9. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
Product Citations
  1. Lin C et al. 2019. Immunity. 50(1):137-151 . PubMed
  2. Turecamo SE, et al. 2018. Matrix Biol. 67:01:00. PubMed
  3. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  4. Ballesteros I, et al. 2014. J Vis Exp. 94: 52031. PubMed
  5. Gallizioli M, et al. 2020. Cell Rep. 33:108291. PubMed
  6. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  7. Xiang G, et al. 2022. Cell Death Dis. 13:451. PubMed
  8. Schädlich IS, et al. 2022. iScience. 25:104470. PubMed
  9. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  10. Cohen K, et al. 2021. Cell Rep. 37:110026. PubMed
  11. Kang H, et al. 2022. Adv Mater. 34:e2106500. PubMed
  12. Dolfi B, et al. 2022. Cell Rep. 39:110949. PubMed
  13. Simpson AP, et al. 2022. Cell Rep. 40:111099. PubMed
  14. Kang J, et al. 2023. JCI Insight. 8: . PubMed
  15. Schick J, et al. 2023. Elife. 12: . PubMed
  16. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  17. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  18. Asare-Bediako B, et al. 2022. Cells. 11:. PubMed
  19. Olofsen PA, et al. 2022. Cells. 11:. PubMed
  20. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  21. van Elsas MJ, et al. 2023. J Immunother Cancer. 11:. PubMed
  22. Garabuczi É, et al. 2023. Front Immunol. 14:1139204. PubMed
  23. Latour YL, et al. 2023. Gut Microbes. 15:2192623. PubMed
  24. Park JA, et al. 2023. J Immunother Cancer. 11:. PubMed
  25. Solier S, et al. 2023. Nature. 617:386. PubMed
  26. Seclì L, et al. 2023. J Immunother Cancer. 11:. PubMed
  27. Fachi JL et al. 2019. Cell reports. 27(3):750-761 . PubMed
  28. Israelow B, et al. 2020. bioRxiv. . PubMed
  29. Gonalves S, et al. 2021. Cell Reports. 34(11):108860. PubMed
  30. Jong RM, et al. 2022. J Immunol. 208:407. PubMed
  31. Tang L, et al. 2021. Oncol Lett. 22:605. PubMed
  32. Zhang K, et al. 2018. PLoS Pathog. 14:e1006925. PubMed
  33. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  34. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  35. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  36. Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed
  37. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  38. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  39. Huard A, et al. 2021. J Immunol. 206:1058. PubMed
  40. Demars A, et al. 2021. PLoS Pathog. 17:e1009887. PubMed
  41. Di Gioia M, et al. 2020. Nat Immunol. 21:42. PubMed
  42. Rao S, et al. 2017. Cell. 168(3):503-516.e12. PubMed
  43. Shemer A, et al. 2020. Immunity. 53(5):1033-1049.e7. PubMed
  44. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  45. Zhou Z, et al. 2019. Oxid Med Cell Longev. 2019:1209307. PubMed
  46. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  47. Han YH, et al. 2021. Science. 373:. PubMed
  48. McCreedy DA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  49. Zhang Y, et al. 2015. PLoS Pathog. 11: e1005167. PubMed
  50. Stutchfield B, et al. 2015. Gastroenterology. 149: 1896-1909.e14. PubMed
  51. Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed
  52. Lagares D, et al. 2017. Sci Transl Med. 9:eaal3765. PubMed
  53. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  54. Honarpisheh P, et al. 2020. J Neuroinflammation. 0.9625. PubMed
  55. Tanaka T, et al. 2015. J Immunol. 194:2004. PubMed
  56. Forbester JL, et al. 2020. J Virol. 94:. PubMed
  57. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  58. Doonan J, et al. 2019. Nat Commun. 10:1554. PubMed
  59. Okubo K, et al. 2021. Cell Reports. 35(7):109142. PubMed
  60. Horn KJ, et al. 2022. Nat Commun. 13:3321. PubMed
  61. Qi S et al. 2016. eLife. 5 pii: e14756. PubMed
  62. Brigas HC, et al. 2021. Cell Reports. 36(9):109574. PubMed
  63. Paiva-Oliveira E, et al. 2017. Histochem Cell Biol. 10.1007/s00418-017-1556-6. PubMed
  64. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  65. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  66. Panea C, et al. 2021. Commun Biol. 4:913. PubMed
  67. Medler TR et al. 2018. Cancer cell. 34(4):561-578 . PubMed
  68. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  69. Zeng W, et al. 2021. STAR Protocols. 2(1):100361. PubMed
  70. Cosentino K, et al. 2022. Mol Cell. 82:933. PubMed
  71. Jamali A, et al. 2020. Cell Reports. 32(9):108099. PubMed
  72. Williams JW, et al. 2017. Circ Res. 121:662. PubMed
  73. Landon J Edgar et al. 2018. Cell chemical biology. 26(1):131-136 . PubMed
  74. Blriot C, et al. 2021. Immunity. :. PubMed
  75. Ermert D, et al. 2016. PLoS Pathog. 11: 1005043. PubMed
  76. Tang C, et al. 2021. Theranostics. 11:9791. PubMed
  77. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  78. Ioannidis L, et al. 2016. J Immunol. 196: 1227 - 1238. PubMed
  79. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  80. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  81. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  82. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  83. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  84. Pinho–Ribeiro FA, et al. 2018. Cell. 173:1083. PubMed
  85. Hadas R, et al. 2020. JCI Insight. 5:00. PubMed
  86. Teo T, et al. 2015. J Virol. 89: 7955-7969. PubMed
  87. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  88. Klein O, et al. 2019. J Allergy Clin Immunol. 144:1074. PubMed
  89. Fontana MF, et al. 2015. Parasite Immunol. 37: 470-478. PubMed
  90. Jiang L, et al. 2020. Cell. 183(5):1219-1233.e18. PubMed
  91. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  92. Budai Z, et al. 2021. Cells. 10:. PubMed
  93. Namkoong H, et al. 2018. PLoS Pathog. 14:e1006955. PubMed
  94. Zhu YP et al. 2018. Cell reports. 24(9):2329-2341 . PubMed
  95. Rustenhoven J, et al. 2021. Cell. 184(4):1000-1016.e27. PubMed
  96. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  97. Canedo T, et al. 2021. Neuropsychopharmacology. 46:2358. PubMed
  98. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  99. Hendrikx S et al. 2019. Cell reports. 26(5):1227-1241 . PubMed
  100. Walsh CM, et al. 2019. Elife. 8:e48448. PubMed
  101. Foster G, et al. 2015. J Immunol. 195: 5380 - 5392. PubMed
  102. Yajjala V, et al. 2016. J Immunol. 196: 4196 - 4203. PubMed
  103. Yin X, et al. 2020. Cell Rep. 33:108278. PubMed
  104. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  105. Heuslein J, et al. 2016. Sci Rep. 6: 27029. PubMed
  106. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  107. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  108. Chen X, et al. 2021. Cell Death Dis. 12:1123. PubMed
  109. Valdearcos M et al. 2017. Cell metabolism. 26(1):185-197 . PubMed
  110. Orr MT, et al. 2019. NPJ Vaccines. 4:1. PubMed
  111. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  112. Ioanna E Galani et al. 2017. Immunity. 46(5):875-890 . PubMed
  113. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  114. Joshi JC, et al. 2020. Cell Rep. 30:4096. PubMed
  115. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  116. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  117. Gangoso E, et al. 2021. Cell. 184:2454. PubMed
  118. Ikezu S, et al. 2021. Mol Psychiatry. 26:1808. PubMed
  119. Awida Z, et al. 2021. Int J Mol Sci. 23:. PubMed
  120. Qi S, et al. 2020. Theranostics. 10:1814. PubMed
  121. Deniset JF et al. 2019. Immunity. 51(1):131-140 . PubMed
  122. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  123. Avgustinova A, et al. 2021. Cell Stem Cell. . PubMed
  124. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  125. Lin C et al. 2019. Immunity. 50(1):137-151 . PubMed
  126. Turecamo SE, et al. 2018. Matrix Biol. 67:01:00. PubMed
  127. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  128. Ballesteros I, et al. 2014. J Vis Exp. 94: 52031. PubMed
  129. Gallizioli M, et al. 2020. Cell Rep. 33:108291. PubMed
  130. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  131. Xiang G, et al. 2022. Cell Death Dis. 13:451. PubMed
  132. Schädlich IS, et al. 2022. iScience. 25:104470. PubMed
  133. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  134. Cohen K, et al. 2021. Cell Rep. 37:110026. PubMed
  135. Kang H, et al. 2022. Adv Mater. 34:e2106500. PubMed
  136. Dolfi B, et al. 2022. Cell Rep. 39:110949. PubMed
  137. Simpson AP, et al. 2022. Cell Rep. 40:111099. PubMed
  138. Kang J, et al. 2023. JCI Insight. 8: . PubMed
  139. Schick J, et al. 2023. Elife. 12: . PubMed
  140. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  141. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  142. Asare-Bediako B, et al. 2022. Cells. 11:. PubMed
  143. Olofsen PA, et al. 2022. Cells. 11:. PubMed
  144. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  145. van Elsas MJ, et al. 2023. J Immunother Cancer. 11:. PubMed
  146. Garabuczi É, et al. 2023. Front Immunol. 14:1139204. PubMed
  147. Latour YL, et al. 2023. Gut Microbes. 15:2192623. PubMed
  148. Park JA, et al. 2023. J Immunother Cancer. 11:. PubMed
  149. Solier S, et al. 2023. Nature. 617:386. PubMed
  150. Seclì L, et al. 2023. J Immunother Cancer. 11:. PubMed
  151. Fachi JL et al. 2019. Cell reports. 27(3):750-761 . PubMed
  152. Israelow B, et al. 2020. bioRxiv. . PubMed
  153. Gonalves S, et al. 2021. Cell Reports. 34(11):108860. PubMed
  154. Jong RM, et al. 2022. J Immunol. 208:407. PubMed
  155. Tang L, et al. 2021. Oncol Lett. 22:605. PubMed
  156. Zhang K, et al. 2018. PLoS Pathog. 14:e1006925. PubMed
  157. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  158. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  159. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  160. Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed
  161. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  162. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  163. Huard A, et al. 2021. J Immunol. 206:1058. PubMed
  164. Demars A, et al. 2021. PLoS Pathog. 17:e1009887. PubMed
  165. Di Gioia M, et al. 2020. Nat Immunol. 21:42. PubMed
  166. Rao S, et al. 2017. Cell. 168(3):503-516.e12. PubMed
  167. Shemer A, et al. 2020. Immunity. 53(5):1033-1049.e7. PubMed
  168. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  169. Zhou Z, et al. 2019. Oxid Med Cell Longev. 2019:1209307. PubMed
  170. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  171. Han YH, et al. 2021. Science. 373:. PubMed
  172. McCreedy DA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  173. Zhang Y, et al. 2015. PLoS Pathog. 11: e1005167. PubMed
  174. Stutchfield B, et al. 2015. Gastroenterology. 149: 1896-1909.e14. PubMed
  175. Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed
  176. Lagares D, et al. 2017. Sci Transl Med. 9:eaal3765. PubMed
  177. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  178. Honarpisheh P, et al. 2020. J Neuroinflammation. 0.9625. PubMed
  179. Tanaka T, et al. 2015. J Immunol. 194:2004. PubMed
  180. Forbester JL, et al. 2020. J Virol. 94:. PubMed
  181. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  182. Doonan J, et al. 2019. Nat Commun. 10:1554. PubMed
  183. Okubo K, et al. 2021. Cell Reports. 35(7):109142. PubMed
  184. Horn KJ, et al. 2022. Nat Commun. 13:3321. PubMed
  185. Qi S et al. 2016. eLife. 5 pii: e14756. PubMed
  186. Brigas HC, et al. 2021. Cell Reports. 36(9):109574. PubMed
  187. Paiva-Oliveira E, et al. 2017. Histochem Cell Biol. 10.1007/s00418-017-1556-6. PubMed
  188. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  189. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  190. Panea C, et al. 2021. Commun Biol. 4:913. PubMed
  191. Medler TR et al. 2018. Cancer cell. 34(4):561-578 . PubMed
  192. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  193. Zeng W, et al. 2021. STAR Protocols. 2(1):100361. PubMed
  194. Cosentino K, et al. 2022. Mol Cell. 82:933. PubMed
  195. Jamali A, et al. 2020. Cell Reports. 32(9):108099. PubMed
  196. Williams JW, et al. 2017. Circ Res. 121:662. PubMed
  197. Landon J Edgar et al. 2018. Cell chemical biology. 26(1):131-136 . PubMed
  198. Blriot C, et al. 2021. Immunity. :. PubMed
  199. Ermert D, et al. 2016. PLoS Pathog. 11: 1005043. PubMed
  200. Tang C, et al. 2021. Theranostics. 11:9791. PubMed
  201. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  202. Ioannidis L, et al. 2016. J Immunol. 196: 1227 - 1238. PubMed
  203. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  204. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  205. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  206. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  207. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  208. Pinho–Ribeiro FA, et al. 2018. Cell. 173:1083. PubMed
  209. Hadas R, et al. 2020. JCI Insight. 5:00. PubMed
  210. Teo T, et al. 2015. J Virol. 89: 7955-7969. PubMed
  211. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  212. Klein O, et al. 2019. J Allergy Clin Immunol. 144:1074. PubMed
  213. Fontana MF, et al. 2015. Parasite Immunol. 37: 470-478. PubMed
  214. Jiang L, et al. 2020. Cell. 183(5):1219-1233.e18. PubMed
  215. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  216. Budai Z, et al. 2021. Cells. 10:. PubMed
  217. Namkoong H, et al. 2018. PLoS Pathog. 14:e1006955. PubMed
  218. Zhu YP et al. 2018. Cell reports. 24(9):2329-2341 . PubMed
  219. Rustenhoven J, et al. 2021. Cell. 184(4):1000-1016.e27. PubMed
  220. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  221. Canedo T, et al. 2021. Neuropsychopharmacology. 46:2358. PubMed
  222. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  223. Hendrikx S et al. 2019. Cell reports. 26(5):1227-1241 . PubMed
  224. Walsh CM, et al. 2019. Elife. 8:e48448. PubMed
  225. Foster G, et al. 2015. J Immunol. 195: 5380 - 5392. PubMed
  226. Yajjala V, et al. 2016. J Immunol. 196: 4196 - 4203. PubMed
  227. Yin X, et al. 2020. Cell Rep. 33:108278. PubMed
  228. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  229. Heuslein J, et al. 2016. Sci Rep. 6: 27029. PubMed
  230. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  231. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  232. Chen X, et al. 2021. Cell Death Dis. 12:1123. PubMed
  233. Valdearcos M et al. 2017. Cell metabolism. 26(1):185-197 . PubMed
  234. Orr MT, et al. 2019. NPJ Vaccines. 4:1. PubMed
  235. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  236. Ioanna E Galani et al. 2017. Immunity. 46(5):875-890 . PubMed
  237. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  238. Joshi JC, et al. 2020. Cell Rep. 30:4096. PubMed
  239. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  240. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  241. Gangoso E, et al. 2021. Cell. 184:2454. PubMed
  242. Ikezu S, et al. 2021. Mol Psychiatry. 26:1808. PubMed
  243. Awida Z, et al. 2021. Int J Mol Sci. 23:. PubMed
  244. Qi S, et al. 2020. Theranostics. 10:1814. PubMed
  245. Deniset JF et al. 2019. Immunity. 51(1):131-140 . PubMed
  246. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  247. Avgustinova A, et al. 2021. Cell Stem Cell. . PubMed
  248. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
RRID
AB_1659241 (BioLegend Cat. No. 128012)
AB_1659242 (BioLegend Cat. No. 128011)

Antigen Details

Structure
14-17 kD protein (134 amino acids), member of the Ly-6 family of GPI linked protein. Ly6 family members share structure homology throughout a distinctive cystein rich protein domain that incorporates O-linked carbohydrates.
Distribution

Ly-6C is expressed primarily on bone marrow myeloid populations, monocytes/macrophages, neutrophils, endothelial cells, and some T cell subsets. Ly-6C is also a marker of memory CD8+ T cells.

Cell Type
Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819.
2. Cerwenka A, et al. 1998. J. Immunol. 161:97.

Gene ID
17067 View all products for this Gene ID
UniProt
View information about Ly-6C on UniProt.org

Related FAQs

How stable is PerCP/Cyanine5.5 tandem as compared to PerCP alone?

PerCP/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.

Other Formats

View All Ly-6C Reagents Request Custom Conjugation
Description Clone Applications
Pacific Blue™ anti-mouse Ly-6C HK1.4 FC
APC anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C HK1.4 FC,IHC-F
Biotin anti-mouse Ly-6C HK1.4 FC
FITC anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 647 anti-mouse Ly-6C HK1.4 FC
PE anti-mouse Ly-6C HK1.4 FC
PerCP/Cyanine5.5 anti-mouse Ly-6C HK1.4 FC
PE/Cyanine7 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 488 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 700 anti-mouse Ly-6C HK1.4 FC
APC/Cyanine7 anti-mouse Ly-6C HK1.4 FC
PerCP anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 570™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 421™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 510™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 605™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 711™ anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C (Maxpar® Ready) HK1.4 FC,CyTOF®
Brilliant Violet 785™ anti-mouse Ly-6C HK1.4 FC
PE/Dazzle™ 594 anti-mouse Ly-6C HK1.4 FC
APC/Fire™ 750 anti-mouse Ly-6C HK1.4 FC
TotalSeq™-A0013 anti-mouse Ly-6C HK1.4 PG
Brilliant Violet 650™ anti-mouse Ly-6C HK1.4 FC
TotalSeq™-C0013 anti-mouse Ly-6C HK1.4 PG
TotalSeq™-B0013 anti-mouse Ly-6C HK1.4 PG
APC/Fire™ 810 anti-mouse Ly-6C Antibody HK1.4 FC
Spark Red™ 718 anti-mouse Ly-6C HK1.4 FC
Spark UV™ 387 anti-mouse Ly-6C HK1.4 FC
PE/Fire™ 810 anti-mouse Ly-6C HK1.4 FC
Spark Blue™ 550 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark Blue™ 574 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
PE/Cyanine5 anti-mouse Ly-6C HK1.4 FC
Spark PLUS B550™ anti-mouse Ly-6C HK1.4 FC
PerCP/Fire™ 806 anti-mouse Ly-6c Antibody HK1.4 FC
Spark YG™ 581 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark YG™ 593 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Spark NIR™ 685 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Go To Top Version: 2    Revision Date: 12.09.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

Pricing & Availability
Clone
HK1.4 (See other available formats)
Regulatory Status
RUO
Other Names
Lymphocyte antigen 6 complex, locus C
Isotype
Rat IgG2c, κ
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Product Citations
publications
HK1dot4_PerCPCy55_061909.jpg
C57BL/6 bone marrow cells stained with HK1.4 PerCP/Cyanine5.5
  • HK1dot4_PerCPCy55_061909.jpg
    C57BL/6 bone marrow cells stained with HK1.4 PerCP/Cyanine5.5
Compare all formats See PerCP/Cyanine5.5 spectral data
Cat # Size Price Quantity Check Availability Save
128012 100 µg NOK2764
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128011 25 µg NOK1164
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Description

Most hematopoietic cells express one or more members of Ly-6 family. The expression of Ly-6 varies with development stage and activation. Ly-6C is a 14-17 kD GPI-linked surface protein expressed on mouse monocyte/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. Ly-6C is reported to be an indicator of memory CD8+ T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
L3 cloned CTL cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PerCP/Cyanine5.5 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

* PerCP/Cyanine5.5 has a maximum absorption of 482 nm and a maximum emission of 690 nm.

Application Notes

Clone HK1.4 does not block the binding of clone RB6-8C58.

Additional reported applications (for relevant formats of this clone) include: in vitro activation of T cells1-3 and immunohistochemistry of frozen sections4.

Application References
  1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819. (Activ)
  2. Herold KC, et al. 1990. Diabetes 39:815. (Activ)
  3. Havran WL, et al. 1988. J. Immunol. 140:1034 (Activ)
  4. Flanagan K, et al. 2008. J. Immunol. 180:3874. (IHC)
  5. Makaroff LE, et al. 2009. P. Natl. Acad. Sci. USA 106:4799. (FC)
  6. Zuber J, et al. 2009. Genes Dev. 23:877. (FC) PubMed
  7. Ribechini E, et al. 2009. Eur. J. Immunol. 39:3538.
  8. Ma C, et al. 2012. J. Leukoc. Biol. 92:1199.
  9. Watson NB, et al. 2015. J Immunol. 194:2796. PubMed
Product Citations
  1. Lin C et al. 2019. Immunity. 50(1):137-151 . PubMed
  2. Turecamo SE, et al. 2018. Matrix Biol. 67:01:00. PubMed
  3. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  4. Ballesteros I, et al. 2014. J Vis Exp. 94: 52031. PubMed
  5. Gallizioli M, et al. 2020. Cell Rep. 33:108291. PubMed
  6. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  7. Xiang G, et al. 2022. Cell Death Dis. 13:451. PubMed
  8. Schädlich IS, et al. 2022. iScience. 25:104470. PubMed
  9. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  10. Cohen K, et al. 2021. Cell Rep. 37:110026. PubMed
  11. Kang H, et al. 2022. Adv Mater. 34:e2106500. PubMed
  12. Dolfi B, et al. 2022. Cell Rep. 39:110949. PubMed
  13. Simpson AP, et al. 2022. Cell Rep. 40:111099. PubMed
  14. Kang J, et al. 2023. JCI Insight. 8: . PubMed
  15. Schick J, et al. 2023. Elife. 12: . PubMed
  16. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  17. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  18. Asare-Bediako B, et al. 2022. Cells. 11:. PubMed
  19. Olofsen PA, et al. 2022. Cells. 11:. PubMed
  20. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  21. van Elsas MJ, et al. 2023. J Immunother Cancer. 11:. PubMed
  22. Garabuczi É, et al. 2023. Front Immunol. 14:1139204. PubMed
  23. Latour YL, et al. 2023. Gut Microbes. 15:2192623. PubMed
  24. Park JA, et al. 2023. J Immunother Cancer. 11:. PubMed
  25. Solier S, et al. 2023. Nature. 617:386. PubMed
  26. Seclì L, et al. 2023. J Immunother Cancer. 11:. PubMed
  27. Fachi JL et al. 2019. Cell reports. 27(3):750-761 . PubMed
  28. Israelow B, et al. 2020. bioRxiv. . PubMed
  29. Gonalves S, et al. 2021. Cell Reports. 34(11):108860. PubMed
  30. Jong RM, et al. 2022. J Immunol. 208:407. PubMed
  31. Tang L, et al. 2021. Oncol Lett. 22:605. PubMed
  32. Zhang K, et al. 2018. PLoS Pathog. 14:e1006925. PubMed
  33. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  34. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  35. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  36. Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed
  37. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  38. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  39. Huard A, et al. 2021. J Immunol. 206:1058. PubMed
  40. Demars A, et al. 2021. PLoS Pathog. 17:e1009887. PubMed
  41. Di Gioia M, et al. 2020. Nat Immunol. 21:42. PubMed
  42. Rao S, et al. 2017. Cell. 168(3):503-516.e12. PubMed
  43. Shemer A, et al. 2020. Immunity. 53(5):1033-1049.e7. PubMed
  44. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  45. Zhou Z, et al. 2019. Oxid Med Cell Longev. 2019:1209307. PubMed
  46. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  47. Han YH, et al. 2021. Science. 373:. PubMed
  48. McCreedy DA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  49. Zhang Y, et al. 2015. PLoS Pathog. 11: e1005167. PubMed
  50. Stutchfield B, et al. 2015. Gastroenterology. 149: 1896-1909.e14. PubMed
  51. Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed
  52. Lagares D, et al. 2017. Sci Transl Med. 9:eaal3765. PubMed
  53. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  54. Honarpisheh P, et al. 2020. J Neuroinflammation. 0.9625. PubMed
  55. Tanaka T, et al. 2015. J Immunol. 194:2004. PubMed
  56. Forbester JL, et al. 2020. J Virol. 94:. PubMed
  57. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  58. Doonan J, et al. 2019. Nat Commun. 10:1554. PubMed
  59. Okubo K, et al. 2021. Cell Reports. 35(7):109142. PubMed
  60. Horn KJ, et al. 2022. Nat Commun. 13:3321. PubMed
  61. Qi S et al. 2016. eLife. 5 pii: e14756. PubMed
  62. Brigas HC, et al. 2021. Cell Reports. 36(9):109574. PubMed
  63. Paiva-Oliveira E, et al. 2017. Histochem Cell Biol. 10.1007/s00418-017-1556-6. PubMed
  64. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  65. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  66. Panea C, et al. 2021. Commun Biol. 4:913. PubMed
  67. Medler TR et al. 2018. Cancer cell. 34(4):561-578 . PubMed
  68. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  69. Zeng W, et al. 2021. STAR Protocols. 2(1):100361. PubMed
  70. Cosentino K, et al. 2022. Mol Cell. 82:933. PubMed
  71. Jamali A, et al. 2020. Cell Reports. 32(9):108099. PubMed
  72. Williams JW, et al. 2017. Circ Res. 121:662. PubMed
  73. Landon J Edgar et al. 2018. Cell chemical biology. 26(1):131-136 . PubMed
  74. Blriot C, et al. 2021. Immunity. :. PubMed
  75. Ermert D, et al. 2016. PLoS Pathog. 11: 1005043. PubMed
  76. Tang C, et al. 2021. Theranostics. 11:9791. PubMed
  77. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  78. Ioannidis L, et al. 2016. J Immunol. 196: 1227 - 1238. PubMed
  79. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  80. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  81. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  82. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  83. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  84. Pinho–Ribeiro FA, et al. 2018. Cell. 173:1083. PubMed
  85. Hadas R, et al. 2020. JCI Insight. 5:00. PubMed
  86. Teo T, et al. 2015. J Virol. 89: 7955-7969. PubMed
  87. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  88. Klein O, et al. 2019. J Allergy Clin Immunol. 144:1074. PubMed
  89. Fontana MF, et al. 2015. Parasite Immunol. 37: 470-478. PubMed
  90. Jiang L, et al. 2020. Cell. 183(5):1219-1233.e18. PubMed
  91. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  92. Budai Z, et al. 2021. Cells. 10:. PubMed
  93. Namkoong H, et al. 2018. PLoS Pathog. 14:e1006955. PubMed
  94. Zhu YP et al. 2018. Cell reports. 24(9):2329-2341 . PubMed
  95. Rustenhoven J, et al. 2021. Cell. 184(4):1000-1016.e27. PubMed
  96. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  97. Canedo T, et al. 2021. Neuropsychopharmacology. 46:2358. PubMed
  98. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  99. Hendrikx S et al. 2019. Cell reports. 26(5):1227-1241 . PubMed
  100. Walsh CM, et al. 2019. Elife. 8:e48448. PubMed
  101. Foster G, et al. 2015. J Immunol. 195: 5380 - 5392. PubMed
  102. Yajjala V, et al. 2016. J Immunol. 196: 4196 - 4203. PubMed
  103. Yin X, et al. 2020. Cell Rep. 33:108278. PubMed
  104. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  105. Heuslein J, et al. 2016. Sci Rep. 6: 27029. PubMed
  106. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  107. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  108. Chen X, et al. 2021. Cell Death Dis. 12:1123. PubMed
  109. Valdearcos M et al. 2017. Cell metabolism. 26(1):185-197 . PubMed
  110. Orr MT, et al. 2019. NPJ Vaccines. 4:1. PubMed
  111. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  112. Ioanna E Galani et al. 2017. Immunity. 46(5):875-890 . PubMed
  113. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  114. Joshi JC, et al. 2020. Cell Rep. 30:4096. PubMed
  115. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  116. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  117. Gangoso E, et al. 2021. Cell. 184:2454. PubMed
  118. Ikezu S, et al. 2021. Mol Psychiatry. 26:1808. PubMed
  119. Awida Z, et al. 2021. Int J Mol Sci. 23:. PubMed
  120. Qi S, et al. 2020. Theranostics. 10:1814. PubMed
  121. Deniset JF et al. 2019. Immunity. 51(1):131-140 . PubMed
  122. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  123. Avgustinova A, et al. 2021. Cell Stem Cell. . PubMed
  124. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
  125. Lin C et al. 2019. Immunity. 50(1):137-151 . PubMed
  126. Turecamo SE, et al. 2018. Matrix Biol. 67:01:00. PubMed
  127. Yu X, et al. 2020. Nat Commun. 11:1110. PubMed
  128. Ballesteros I, et al. 2014. J Vis Exp. 94: 52031. PubMed
  129. Gallizioli M, et al. 2020. Cell Rep. 33:108291. PubMed
  130. Marchelletta RR, et al. 2021. J Clin Invest. 131:. PubMed
  131. Xiang G, et al. 2022. Cell Death Dis. 13:451. PubMed
  132. Schädlich IS, et al. 2022. iScience. 25:104470. PubMed
  133. Hutter K, et al. 2022. Front Immunol. 13:967914. PubMed
  134. Cohen K, et al. 2021. Cell Rep. 37:110026. PubMed
  135. Kang H, et al. 2022. Adv Mater. 34:e2106500. PubMed
  136. Dolfi B, et al. 2022. Cell Rep. 39:110949. PubMed
  137. Simpson AP, et al. 2022. Cell Rep. 40:111099. PubMed
  138. Kang J, et al. 2023. JCI Insight. 8: . PubMed
  139. Schick J, et al. 2023. Elife. 12: . PubMed
  140. Tunali G, et al. 2023. J Clin Invest. :. PubMed
  141. Awida Z, et al. 2022. Int J Mol Sci. 23:. PubMed
  142. Asare-Bediako B, et al. 2022. Cells. 11:. PubMed
  143. Olofsen PA, et al. 2022. Cells. 11:. PubMed
  144. Banerjee K, et al. 2023. Eur J Immunol. 53:e2250161. PubMed
  145. van Elsas MJ, et al. 2023. J Immunother Cancer. 11:. PubMed
  146. Garabuczi É, et al. 2023. Front Immunol. 14:1139204. PubMed
  147. Latour YL, et al. 2023. Gut Microbes. 15:2192623. PubMed
  148. Park JA, et al. 2023. J Immunother Cancer. 11:. PubMed
  149. Solier S, et al. 2023. Nature. 617:386. PubMed
  150. Seclì L, et al. 2023. J Immunother Cancer. 11:. PubMed
  151. Fachi JL et al. 2019. Cell reports. 27(3):750-761 . PubMed
  152. Israelow B, et al. 2020. bioRxiv. . PubMed
  153. Gonalves S, et al. 2021. Cell Reports. 34(11):108860. PubMed
  154. Jong RM, et al. 2022. J Immunol. 208:407. PubMed
  155. Tang L, et al. 2021. Oncol Lett. 22:605. PubMed
  156. Zhang K, et al. 2018. PLoS Pathog. 14:e1006925. PubMed
  157. Mylonas K, et al. 2015. Immunobiology. 220: 924-933. PubMed
  158. Leach SM, et al. 2020. Cell Rep. 33:108337. PubMed
  159. Yilmaz B, et al. 2021. Cell Host Microbe. 29(4):650-663.e9. PubMed
  160. Song J, et al. 2021. J Am Heart Assoc. 10:e017329. PubMed
  161. Xu ZH, et al. 2021. Mediators Inflamm. 2021:8856326. PubMed
  162. Yang Y, et al. 2020. Cell Death Discov. 0.293055556. PubMed
  163. Huard A, et al. 2021. J Immunol. 206:1058. PubMed
  164. Demars A, et al. 2021. PLoS Pathog. 17:e1009887. PubMed
  165. Di Gioia M, et al. 2020. Nat Immunol. 21:42. PubMed
  166. Rao S, et al. 2017. Cell. 168(3):503-516.e12. PubMed
  167. Shemer A, et al. 2020. Immunity. 53(5):1033-1049.e7. PubMed
  168. Park JA, et al. 2021. J Hematol Oncol. 14:142. PubMed
  169. Zhou Z, et al. 2019. Oxid Med Cell Longev. 2019:1209307. PubMed
  170. Ellis G, et al. 2015. EMBO Rep. 16: 1203-1218. PubMed
  171. Han YH, et al. 2021. Science. 373:. PubMed
  172. McCreedy DA et al. 2018. eNeuro. 5(4) pii: ENEURO. PubMed
  173. Zhang Y, et al. 2015. PLoS Pathog. 11: e1005167. PubMed
  174. Stutchfield B, et al. 2015. Gastroenterology. 149: 1896-1909.e14. PubMed
  175. Jeljeli M, et al. 2020. Cell Rep. 33:108325. PubMed
  176. Lagares D, et al. 2017. Sci Transl Med. 9:eaal3765. PubMed
  177. Varol D et al. 2017. Immunity. 46(6):1030-1044 . PubMed
  178. Honarpisheh P, et al. 2020. J Neuroinflammation. 0.9625. PubMed
  179. Tanaka T, et al. 2015. J Immunol. 194:2004. PubMed
  180. Forbester JL, et al. 2020. J Virol. 94:. PubMed
  181. Cassidy BR, et al. 2020. J Neuroinflammation. 17:259. PubMed
  182. Doonan J, et al. 2019. Nat Commun. 10:1554. PubMed
  183. Okubo K, et al. 2021. Cell Reports. 35(7):109142. PubMed
  184. Horn KJ, et al. 2022. Nat Commun. 13:3321. PubMed
  185. Qi S et al. 2016. eLife. 5 pii: e14756. PubMed
  186. Brigas HC, et al. 2021. Cell Reports. 36(9):109574. PubMed
  187. Paiva-Oliveira E, et al. 2017. Histochem Cell Biol. 10.1007/s00418-017-1556-6. PubMed
  188. Harnett MM, et al. 2022. Front Immunol. 13:953053. PubMed
  189. Golden TN, et al. 2022. Front Pharmacol. 12:761496. PubMed
  190. Panea C, et al. 2021. Commun Biol. 4:913. PubMed
  191. Medler TR et al. 2018. Cancer cell. 34(4):561-578 . PubMed
  192. Engler AE, et al. 2020. Cell Reports. 33(13):108553. PubMed
  193. Zeng W, et al. 2021. STAR Protocols. 2(1):100361. PubMed
  194. Cosentino K, et al. 2022. Mol Cell. 82:933. PubMed
  195. Jamali A, et al. 2020. Cell Reports. 32(9):108099. PubMed
  196. Williams JW, et al. 2017. Circ Res. 121:662. PubMed
  197. Landon J Edgar et al. 2018. Cell chemical biology. 26(1):131-136 . PubMed
  198. Blriot C, et al. 2021. Immunity. :. PubMed
  199. Ermert D, et al. 2016. PLoS Pathog. 11: 1005043. PubMed
  200. Tang C, et al. 2021. Theranostics. 11:9791. PubMed
  201. Rashid MH, et al. 2021. Oncol Rep. 45:1171. PubMed
  202. Ioannidis L, et al. 2016. J Immunol. 196: 1227 - 1238. PubMed
  203. Yang Y, et al. 2020. Cell Death Discov. 6:62. PubMed
  204. Wuggenig P, et al. 2020. Commun Biol. 3:130. PubMed
  205. Ali S, et al. 2021. PLoS One. 16:e0246646. PubMed
  206. Nuro-Gyina PK, et al. 2021. J Immunol. 207:868. PubMed
  207. Dahlgren MW et al. 2019. Immunity. 50(3):707-722 . PubMed
  208. Pinho–Ribeiro FA, et al. 2018. Cell. 173:1083. PubMed
  209. Hadas R, et al. 2020. JCI Insight. 5:00. PubMed
  210. Teo T, et al. 2015. J Virol. 89: 7955-7969. PubMed
  211. Matsumura T, et al. 2022. Nat Commun. 13:7064. PubMed
  212. Klein O, et al. 2019. J Allergy Clin Immunol. 144:1074. PubMed
  213. Fontana MF, et al. 2015. Parasite Immunol. 37: 470-478. PubMed
  214. Jiang L, et al. 2020. Cell. 183(5):1219-1233.e18. PubMed
  215. Kumari P, et al. 2021. Cell Reports. 35(3):109012. PubMed
  216. Budai Z, et al. 2021. Cells. 10:. PubMed
  217. Namkoong H, et al. 2018. PLoS Pathog. 14:e1006955. PubMed
  218. Zhu YP et al. 2018. Cell reports. 24(9):2329-2341 . PubMed
  219. Rustenhoven J, et al. 2021. Cell. 184(4):1000-1016.e27. PubMed
  220. Huo M, et al. 2017. FASEB J. 10.1096/fj.201601030R. PubMed
  221. Canedo T, et al. 2021. Neuropsychopharmacology. 46:2358. PubMed
  222. Nishio H, et al. 2020. Regen Ther. 14:262. PubMed
  223. Hendrikx S et al. 2019. Cell reports. 26(5):1227-1241 . PubMed
  224. Walsh CM, et al. 2019. Elife. 8:e48448. PubMed
  225. Foster G, et al. 2015. J Immunol. 195: 5380 - 5392. PubMed
  226. Yajjala V, et al. 2016. J Immunol. 196: 4196 - 4203. PubMed
  227. Yin X, et al. 2020. Cell Rep. 33:108278. PubMed
  228. Freed-Pastor WA, et al. 2021. Cancer Cell. 39:1342. PubMed
  229. Heuslein J, et al. 2016. Sci Rep. 6: 27029. PubMed
  230. Jiang Y, et al. 2015. MBio. 6: e01426-15. PubMed
  231. Lei Y, et al. 2021. Sci Adv. 7:. PubMed
  232. Chen X, et al. 2021. Cell Death Dis. 12:1123. PubMed
  233. Valdearcos M et al. 2017. Cell metabolism. 26(1):185-197 . PubMed
  234. Orr MT, et al. 2019. NPJ Vaccines. 4:1. PubMed
  235. Sadtler K, et al. 2017. Tissue Eng Part A. 23:1044. PubMed
  236. Ioanna E Galani et al. 2017. Immunity. 46(5):875-890 . PubMed
  237. Boguslawski KM, et al. 2020. Sci Adv. 6:eaax7515. PubMed
  238. Joshi JC, et al. 2020. Cell Rep. 30:4096. PubMed
  239. Tran S, et al. 2020. Immunity. 53(3):627-640.e5. PubMed
  240. Al-Zaeed N, et al. 2021. Cell Death Dis. 12:611. PubMed
  241. Gangoso E, et al. 2021. Cell. 184:2454. PubMed
  242. Ikezu S, et al. 2021. Mol Psychiatry. 26:1808. PubMed
  243. Awida Z, et al. 2021. Int J Mol Sci. 23:. PubMed
  244. Qi S, et al. 2020. Theranostics. 10:1814. PubMed
  245. Deniset JF et al. 2019. Immunity. 51(1):131-140 . PubMed
  246. Yáñez A et al. 2017. Immunity. 47(5):890-902 . PubMed
  247. Avgustinova A, et al. 2021. Cell Stem Cell. . PubMed
  248. Steinmetz O, et al. 2016. J Infect Dis. 10.1093/infdis/jiv763. PubMed
RRID
AB_1659241 (BioLegend Cat. No. 128012)
AB_1659242 (BioLegend Cat. No. 128011)

Antigen Details

Structure
14-17 kD protein (134 amino acids), member of the Ly-6 family of GPI linked protein. Ly6 family members share structure homology throughout a distinctive cystein rich protein domain that incorporates O-linked carbohydrates.
Distribution

Ly-6C is expressed primarily on bone marrow myeloid populations, monocytes/macrophages, neutrophils, endothelial cells, and some T cell subsets. Ly-6C is also a marker of memory CD8+ T cells.

Cell Type
Endothelial cells, Macrophages, Monocytes, Neutrophils, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Jutila MA, et al. 1988. Eur. J. Immunol. 18:1819.
2. Cerwenka A, et al. 1998. J. Immunol. 161:97.

Gene ID
17067 View all products for this Gene ID
UniProt
View information about Ly-6C on UniProt.org

Related FAQs

How stable is PerCP/Cyanine5.5 tandem as compared to PerCP alone?

PerCP/Cyanine5.5 is quite photostable and also better than PerCP alone in withstanding fixation.

Other Formats

View All Ly-6C Reagents Request Custom Conjugation
Description Clone Applications
Pacific Blue™ anti-mouse Ly-6C HK1.4 FC
APC anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C HK1.4 FC,IHC-F
Biotin anti-mouse Ly-6C HK1.4 FC
FITC anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 647 anti-mouse Ly-6C HK1.4 FC
PE anti-mouse Ly-6C HK1.4 FC
PerCP/Cyanine5.5 anti-mouse Ly-6C HK1.4 FC
PE/Cyanine7 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 488 anti-mouse Ly-6C HK1.4 FC
Alexa Fluor® 700 anti-mouse Ly-6C HK1.4 FC
APC/Cyanine7 anti-mouse Ly-6C HK1.4 FC
PerCP anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 570™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 421™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 510™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 605™ anti-mouse Ly-6C HK1.4 FC
Brilliant Violet 711™ anti-mouse Ly-6C HK1.4 FC
Purified anti-mouse Ly-6C (Maxpar® Ready) HK1.4 FC,CyTOF®
Brilliant Violet 785™ anti-mouse Ly-6C HK1.4 FC
PE/Dazzle™ 594 anti-mouse Ly-6C HK1.4 FC
APC/Fire™ 750 anti-mouse Ly-6C HK1.4 FC
TotalSeq™-A0013 anti-mouse Ly-6C HK1.4 PG
Brilliant Violet 650™ anti-mouse Ly-6C HK1.4 FC
TotalSeq™-C0013 anti-mouse Ly-6C HK1.4 PG
TotalSeq™-B0013 anti-mouse Ly-6C HK1.4 PG
APC/Fire™ 810 anti-mouse Ly-6C Antibody HK1.4 FC
Spark Red™ 718 anti-mouse Ly-6C HK1.4 FC
Spark UV™ 387 anti-mouse Ly-6C HK1.4 FC
PE/Fire™ 810 anti-mouse Ly-6C HK1.4 FC
Spark Blue™ 550 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark Blue™ 574 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
PE/Cyanine5 anti-mouse Ly-6C HK1.4 FC
Spark PLUS B550™ anti-mouse Ly-6C HK1.4 FC
PerCP/Fire™ 806 anti-mouse Ly-6c Antibody HK1.4 FC
Spark YG™ 581 anti-mouse Ly-6C (Flexi-Fluor™) HK1.4 FC
Spark YG™ 593 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Spark NIR™ 685 anti-mouse Ly-6C (Flexi-Fluor™) Antibody HK1.4 FC
Go To Top Version: 2    Revision Date: 12.09.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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