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Propidium Iodide Solution Propidium Iodide Solution

Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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Product Citations
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421301 2 mL NOK446
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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  2. Darzynkiewicz Z, et al. 1992. Cytometry 13(8):795.
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  4. Sakimoto I, et al. 2006. Cancer Research 66:2287.PubMed
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  7. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  8. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  9. Beggs KM, et al. 2014. Toxicol Sci. 137:91. PubMed
  10. Ewald SE, et al. 2014. Infect Immun. 82:460. PubMed
  11. Tsou WI, et al. 2014. J Biol Chem. 289:25750. PubMed
  12. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
Product Citations
  1. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  2. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  3. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  4. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  5. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  6. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  7. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  8. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  9. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  10. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  11. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  12. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  13. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  14. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  15. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  16. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  17. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  18. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  19. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  20. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  21. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  22. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  23. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  24. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  25. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  26. Quintela M, et al. 2023. Br J Cancer. . PubMed
  27. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  28. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  29. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  30. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  31. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  32. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  33. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  34. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  35. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  36. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  37. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  38. McNeal AS, et al. 2021. Elife. 10:. PubMed
  39. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  40. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  41. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  42. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  43. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  44. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  45. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  46. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  47. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  48. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  49. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  50. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  51. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  52. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  53. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  54. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  55. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  56. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  57. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  58. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  59. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  60. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  61. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  62. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  63. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  64. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  65. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  66. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  67. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  68. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  69. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  70. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  71. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  72. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  73. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  74. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  75. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  76. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  77. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  78. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  79. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  80. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  81. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  82. Wang J, et al. 2022. J Clin Invest. :. PubMed
  83. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  84. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  85. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  86. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  87. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  88. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  89. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  90. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  91. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  92. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  93. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  94. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  95. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  96. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  97. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  98. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  99. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  100. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  101. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  102. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  103. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  104. Harro CM, et al. 2020. J Clin Invest. . PubMed
  105. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  106. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  107. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  108. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  109. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  110. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  111. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  112. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  113. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  114. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  115. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  116. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  117. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  118. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  119. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  120. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  121. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  122. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  123. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  124. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  125. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  126. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  127. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  128. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  129. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  130. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  131. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  132. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  133. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  134. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  135. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  136. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  137. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  138. Vulin M, et al. 2022. Oncogene. :. PubMed
  139. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  140. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  141. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  142. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  143. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  144. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  145. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  146. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  147. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  148. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  149. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  150. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  151. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  152. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  153. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  154. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  155. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  156. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  157. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  158. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  159. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  160. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  161. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  162. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  163. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  164. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  165. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  166. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  167. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  168. Quintela M, et al. 2023. Br J Cancer. . PubMed
  169. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  170. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  171. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  172. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  173. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  174. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  175. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  176. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  177. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  178. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  179. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  180. McNeal AS, et al. 2021. Elife. 10:. PubMed
  181. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  182. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  183. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  184. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  185. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  186. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  187. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  188. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  189. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  190. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  191. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  192. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  193. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  194. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  195. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  196. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  197. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  198. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  199. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  200. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  201. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  202. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  203. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  204. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  205. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  206. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  207. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  208. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  209. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  210. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  211. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  212. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  213. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  214. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  215. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  216. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  217. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  218. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  219. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  220. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  221. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  222. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  223. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  224. Wang J, et al. 2022. J Clin Invest. :. PubMed
  225. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  226. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  227. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  228. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  229. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  230. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  231. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  232. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  233. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  234. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  235. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  236. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  237. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  242. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  243. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  244. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  245. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  246. Harro CM, et al. 2020. J Clin Invest. . PubMed
  247. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  248. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  249. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  250. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  251. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  252. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  253. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  254. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  255. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  256. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  257. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  258. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  259. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  260. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  261. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  262. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  263. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  264. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  265. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  266. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  267. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  268. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  269. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  270. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  271. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  272. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  273. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  274. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  275. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  276. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  277. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  278. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  279. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  280. Vulin M, et al. 2022. Oncogene. :. PubMed
  281. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  282. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  283. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  284. Juel H, et al. 2013. PLoS One. 8:64619. PubMed

Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10.08.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Pricing & Availability
Regulatory Status
RUO
Other Names
PI
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Product Citations
publications
See Propidium Iodide spectral data
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421301 2 mL NOK446
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Description

Propidium iodide (PI) is a fluorescent dye that binds to DNA. When excited by 488nm laser light, it can be detected with in the PE/Texas Red® channel with a bandpass filter 610/10. It is commonly used in evaluation of cell viability or DNA content in cell cycle analysis by flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Formulation
Phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/ml
Storage & Handling
The solution should be stored undiluted between 2°C and 8°C, and protect from light. Caution: This solution contains hazardous material; handle with care.
Application

FC - Quality tested
Recommended Usage

The suggested use of this solution for viability staining is 10 µl per million cells in 0.5 ml/test, and incubate for 15 minutes at 4 °C before analysis. For Cell Cycle analysis, please see our Propidium Iodide Cell Cycle Staining Protocol. Caution: This solution is toxigenic and mutagenic; handle with care.

Excitation Laser
Blue Laser (488 nm)
Application Notes

Propidium Iodide Solution can be used in evaluation of apoptosis, cell viability and cell cycle analysis by flow cytometry.

Application References
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Product Citations
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  2. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
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  75. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  76. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  77. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  78. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  79. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  80. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  81. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  82. Wang J, et al. 2022. J Clin Invest. :. PubMed
  83. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  84. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
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  98. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  99. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
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  101. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
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  108. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
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  112. Woo MS, et al. 2021. J Exp Med. :218. PubMed
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  116. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  117. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  118. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  119. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  120. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  121. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  122. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  123. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  124. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  125. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  126. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  127. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  128. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  129. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  130. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  131. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  132. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  133. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  134. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  135. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  136. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  137. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
  138. Vulin M, et al. 2022. Oncogene. :. PubMed
  139. Popa S, et al. 2020. Wellcome Open Res. 0.249305556. PubMed
  140. Liu Q, et al. 2016. Cell Death Dis. 1.93125. PubMed
  141. Mahmoudi M, et al. 2016. Sci Rep. 6:26960. PubMed
  142. Juel H, et al. 2013. PLoS One. 8:64619. PubMed
  143. Glynn RA, et al. 2022. J Immunol. 208:371. PubMed
  144. Marques de Menezes EG, et al. 2022. MBio. 13:e0300521. PubMed
  145. Das Gupta D, et al. 2022. Cell Death Differ. 29:2163. PubMed
  146. Qin L, et al. 2022. Sci Adv. 8:eabn3774. PubMed
  147. Cheng Y, et al. 2022. Cell Mol Gastroenterol Hepatol. 14:964. PubMed
  148. Choi UY, et al. 2022. Cell Rep. 40:111234. PubMed
  149. Park J, et al. 2022. Animals (Basel). 12: . PubMed
  150. Papakonstantinou A, et al. 2022. Int J Mol Sci. 24: . PubMed
  151. Blal K, et al. 2023. Cancers (Basel). 15: . PubMed
  152. Xiong E, et al. 2023. Front Immunol. 13:1083119. PubMed
  153. Tanaka T, et al. 2023. Nat Immunol. 24:439. PubMed
  154. Bhardwaj M, et al. 2023. J Clin Invest. :. PubMed
  155. Hochrein SM, et al. 2022. Cell Metab. 34:516. PubMed
  156. Wenes M, et al. 2022. Cell Metab. 34:731. PubMed
  157. Li W, et al. 2019. Aging (Albany NY). 0.99375. PubMed
  158. Liu H, et al. 2012. Int J Biochem Cell Biol. 45:408. PubMed
  159. Ewald S, et al. 2014. Infect Immun . 82:460. PubMed
  160. Guo H, et al. 2016. Sci Rep. 6:37559. PubMed
  161. Smith A, et al. 2017. Sci Rep. 7:41872. PubMed
  162. Evans SJ, et al. 2022. Toxicol In Vitro. 83:105415. PubMed
  163. Hagege A, et al. 2022. Cell Rep Med. 3:100659. PubMed
  164. Tintelnot J, et al. 2023. Nature. 615:168. PubMed
  165. Ohuchi K, et al. 2023. Biomed Rep. 18:28. PubMed
  166. Quintela M, et al. 2023. Clin Epigenetics. 15:63. PubMed
  167. Buckley MT, et al. 2023. Nat Aging. 3:121. PubMed
  168. Quintela M, et al. 2023. Br J Cancer. . PubMed
  169. Sohrabi N, et al. 2023. Iran J Public Health. 52:633. PubMed
  170. Papsdorf K, et al. 2023. Nat Cell Biol. 25:672. PubMed
  171. Schwartz PB, et al. 2023. PLoS Genet. 19:e1010770. PubMed
  172. Wyrobnik I, et al. 2023. Oncoimmunology. 12:2219164. PubMed
  173. Lindqvist B, et al. 2022. PLoS Pathog. 18:e1010555. PubMed
  174. Chan J, et al. 2017. Oncogene. 10.1038/onc.2017.319. PubMed
  175. Uroda T, et al. 2019. Mol Cell. 75:982. PubMed
  176. Hamel Y, et al. 2021. Cell Rep Med. 2:100370. PubMed
  177. Castellanos CA, et al. 2021. Sci Immunol. 6:eabh0707. PubMed
  178. Leeth C, et al. 2021. Animals (Basel). 11:. PubMed
  179. Chen M, et al. 2021. Cancers (Basel). 13:. PubMed
  180. McNeal AS, et al. 2021. Elife. 10:. PubMed
  181. Neumann CKA, et al. 2020. Mol Metab. 34:136. PubMed
  182. Yoshioka H, et al. 2021. Front Cell Dev Biol. 9:621045. PubMed
  183. Yang Y, et al. 2021. Metabolism. 123:154863. PubMed
  184. Sun X, et al. 2022. JCI Insight. 7: . PubMed
  185. Coray M, et al. 2022. Int J Mol Sci. 23:. PubMed
  186. He Y, et al. 2020. Nat Commun. 11:1996. PubMed
  187. Fukushima T, et al. 2019. Cell Rep. 29:4144. PubMed
  188. Ren Q, et al. 2013. PLoS One. 8:74732. PubMed
  189. Zhang W, et al. 2021. J Clin Invest. 131:. PubMed
  190. Ambrosi TH, et al. 2021. Elife. 10: . PubMed
  191. Zeng H, et al. 2018. Cancer Cell. 34:56:00. PubMed
  192. Lei W, et al. 2020. Sci Rep. 10:7004. PubMed
  193. Wang Y, et al. 2019. Cell. 179:1144. PubMed
  194. Zhang M, et al. 2017. Oncol Lett. 3.069444444. PubMed
  195. Schrier S, et al. 2016. Sci Rep. 6:34942. PubMed
  196. O'Neill K, et al. 2016. Genes Dev. 30: 973-988. PubMed
  197. Sapanidou V, et al. 2015. Theriogenology. . PubMed
  198. Kong S, et al. 2014. J Immunol. 193:5515. PubMed
  199. Zou PA, et al. 2021. Oncol Lett. 22:648. PubMed
  200. Masuda T, et al. 2022. iScience. 25:104781. PubMed
  201. Chen C, et al. 2019. Cell Rep. 29:4200. PubMed
  202. Liu L, et al. 2019. Cell Prolif. :e12718. PubMed
  203. Feng L, et al. 2016. J Cell Sci. 129: 2202 - 2212. PubMed
  204. Lange N, et al. 2016. PLoS One. 11: 0160843. PubMed
  205. Jordan PM, et al. 2020. Cell Rep. 33:108247. PubMed
  206. Liu Y, et al. 2017. Acta Biomater. 10.1016/j.actbio.2017.08.021. PubMed
  207. Reighard SD, et al. 2020. Cell Rep Med. :1. PubMed
  208. Zhang S, et al. 2020. Front Immunol. 1.757638889. PubMed
  209. Xu B, et al. 2016. Leukemia. 10.1038/leu.2016.297. PubMed
  210. Yang M, et al. 2021. Med Sci Monit. 27:e930083. PubMed
  211. Domenis R, et al. 2017. PLoS One. 10.1371/journal.pone.0169932. PubMed
  212. Walter F, et al. 2020. PLoS One. 15:e0239369. PubMed
  213. Matsuda K, et al. 2021. Cell Rep Methods. 1:100122. PubMed
  214. Pang K, et al. 2022. Cell Death Dis. 13:169. PubMed
  215. Tang X, et al. 2021. Transl Cancer Res. 10:2120. PubMed
  216. Liu H, et al. 2020. Cell Death Dis. 0.767361111. PubMed
  217. Li L, et al. 2018. Oncol Lett. 4.184722222. PubMed
  218. Jung E, et al. 2017. J Neurosci. 37:6837. PubMed
  219. Basso-Ricci L, et al. 2017. Cytometry A. 10.1002/cyto.a.23148. PubMed
  220. Zhang X, et al. 2020. Eur J Med Chem. 112186:192. PubMed
  221. Mensen A, et al. 2015. Biol Blood Marrow Transplant. Available online 10 August 2015. PubMed
  222. Zhao W, et al. 2013. Clin Immunol. 149:119. PubMed
  223. Shanahan MT, et al. 2021. Am J Physiol Gastrointest Liver Physiol. 321:G668. PubMed
  224. Wang J, et al. 2022. J Clin Invest. :. PubMed
  225. Trudu M, et al. 2022. Front Oncol. 12:968208. PubMed
  226. Litzenburger UM, et al. 2017. Genome Biol. 18:15. PubMed
  227. Li Y, et al. 2016. Int J Lower Extrem Wounds. 10.1177/1534734616649485. PubMed
  228. Hu D, et al. 2020. Proc Natl Acad Sci U S A. 117:30639. PubMed
  229. Li Q, et al. 2020. Acta Biochim Biophys Sin (Shanghai). 52:1131. PubMed
  230. Moribe F, et al. 2021. PLoS One. 16:e0237554. PubMed
  231. Xue G, et al. 2021. Nat Biomed Eng. 5:1306. PubMed
  232. Lasrado N, et al. 2022. iScience. 25:103865. PubMed
  233. Perl AL, et al. 2019. J Biol Chem. 294:17043. PubMed
  234. Diaz Osterman CJ, et al. 2019. Elife. 8:e47327. PubMed
  235. Hosokawa T, et al. 2017. J Immunol. 10.4049/jimmunol.1700157. PubMed
  236. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0124-1. PubMed
  237. L Chang, Y Li, D Kaplan 2016. Sci Rep. 6:36862. PubMed
  238. Tsou W, et al. 2014. J Biol Chem. 289:25750. PubMed
  239. Oubaha M, et al. 2016. Sci Transl Med. 8: 362ra144. PubMed
  240. Polk A, et al. 2016. Clin Cancer Res. 22(24):6118-6128. PubMed
  241. Pal P, et al. 2021. J Med Chem. 64:14230. PubMed
  242. Hedemann N, et al. 2021. Cancers (Basel). 13:. PubMed
  243. Xie B, et al. 2021. J Immunol. 206:1515. PubMed
  244. El-Hafeez A, et al. 2017. Cytotechnology. 10.1007/s10616-017-0116-1. PubMed
  245. Xie M, et al. 2017. BMC Cancer . 10.1186/s12885-017-3291-8. PubMed
  246. Harro CM, et al. 2020. J Clin Invest. . PubMed
  247. Imura Y, et al. 2020. JCI Insight. :5. PubMed
  248. Suzuki S, et al. 2021. STAR Protocols. 2:100683. PubMed
  249. Vickman R, et al. 2016. Mol Cancer Res. 14: 776 - 786. PubMed
  250. Matsubara T, et al. 2022. J Exp Med. 219:. PubMed
  251. Huang K, et al. 2018. Biol Open. 7:bio029470. PubMed
  252. Wang H, et al. 2019. Nat Commun. 4.388194444. PubMed
  253. M H, et al. 2016. Cell Transplant. 25: 811-27. PubMed
  254. Woo MS, et al. 2021. J Exp Med. :218. PubMed
  255. Viereckl MJ, et al. 2022. Biomolecules. 12:. PubMed
  256. Deng Y, et al. 2021. Nat Commun. 12:7041. PubMed
  257. Liu X, et al. 2019. Mol Cancer Ther. 18:706. PubMed
  258. Yang X, et al. 2017. J Control Release. 10.1016/j.jconrel.2017.07.014. PubMed
  259. Hughes K, et al. 2017. Open Bio. 10.1098/rsob.160155. PubMed
  260. Resch U, et al. 2016. MBio. 7: e00207-16. PubMed
  261. Bao W, et al. 2016. Sci Rep. 6:22579. PubMed
  262. Ghura H, et al. 2021. Neoplasia. 23:837. PubMed
  263. Bjørnstad R, et al. 2019. Mol Cancer Ther. 1.14375. PubMed
  264. Beggs K, et al. 2014. Toxicol Sci. 137:91. PubMed
  265. Wang C, et al. 2017. Drug Deliv. 10.1080/10717544.2017.1293195. PubMed
  266. Nilsri N, et al. 2021. Sci Rep. 5255:11. PubMed
  267. Widodo N, et al. 2022. F1000Res. 11:169. PubMed
  268. Tu Z, et al. 2022. Cell Rep. 40:111072. PubMed
  269. Bensberg M, et al. 2021. Proc Natl Acad Sci U S A. 118:. PubMed
  270. He Y, et al. 2020. J Hematol Oncol. 0.607638889. PubMed
  271. Goel S, et al. 2021. Nat Commun. 12:5325. PubMed
  272. Szeto C, et al. 2022. Nat Commun. 13:4951. PubMed
  273. Siddhartha V, et al. 2017. Artif Cells Nanomed Biotechnol . 10.1080/21691401.2017.1313267. PubMed
  274. Viseshakul N, et al. 2017. Parasitol Res. 10.1007/s00436-017-5589-5. PubMed
  275. Chmielewski M and Abken H 2017. Cell Rep.. 10.1016/j.celrep.2017.11.063. PubMed
  276. Sakimoto I, et al. 2006. Cancer Res. 66:2287. PubMed
  277. Namas R, et al. 2016. Lupus Sci Med. 3: e000148. PubMed
  278. Chen Y, et al. 2016. J Biol Chem. 291: 13216 - 13228. PubMed
  279. Deng BB, et al. 2020. Cell Biol Int. 44:1890. PubMed
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Antigen Details

Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroscience
Gene ID
NA

Related FAQs

Why is washing not recommended after the addition 7-AAD or PI addition when assessing viability?

These dyes bind in equilibrium with DNA. Therefore, external dye concentration must be maintained during analysis and the dye should not be washed out.

Go To Top Version: 2    Revision Date: 10.08.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

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